Faculty
Evan Sadler.jpg

J. Evan Sadler, MD, PhD

Professor
Department of Medicine
Hematology Division
Department of Biochemistry & Molecular Biophysics

Contact

  • 314-362-9029 (tel)
  • 314-454-3012 (fax)
  • Room 10027 Clinical Sciences Research Building (office)
  • Room 10034 Clinical Sciences Research Building (lab)
  • Hematology Division
    Campus Box 8125
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Invited Publications

  • What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura
    Sadler JE
    Hematology Am Soc Hematol Educ Program 2015 Dec 5;2015(1):631-6
  • Atypical HUS may become a diagnosis of inclusion
    Sadler JE
    Blood 2015 Jun 4;125(23):3525-6
  • Thrombotic microangiopathies
    Sadler JE
    In: Williams Hematology, Ninth Edition (K Kaushansky, MA Lichtman, JT Prchal, M Levi, OW Press, LJ Burns, MA Caligiuri, eds) McGraw-Hill, New York, 2016; 2253-2266
  • Microangiopathic hemolytic anemia
    Majerus EM, Sadler JE
    In: Anemia: Pathophysiology, diagnosis and management (EJ Benz Jr, N Berliner, F Schiffman, eds) Cambridge University Press, Cambridge, UK, in press
  • von Willebrand factor in its native environment
    Sadler JE
    Blood 2013 Apr 4;121(14):2583-4
  • Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
    McCrae KR, Sadler JE, Cines D
    In: Hematology: Basic Principles and Practice, Sixth Edition (R Hoffman, EJ Benz, LE Silberstein, HE Heslop, JI Weitz, J Anastasi, eds) Saunders, Philadelphia, 2013; 1925-1939
  • von Willebrand disease: diagnosis, classification, and treatment
    Sadler JE, Lillicrap D
    In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, Sixth Edition (VJ Marder, WC Aird, JS Bennett, S Schulman, GC White, II, eds) Lippincott Williams & Wilkins, Philadelphia, 2013; 670-683
  • Should all adult patients with diarrhoea-associated HUS receive plasma exchange?
    Tarr PI, Sadler JE, Chandler WL, George JN, Tsai HM
    Lancet 2012 Feb 11;379(9815):516
  • Weibel-Palade bodies
    Sadler JE
    Clin Adv Hematol Oncol 2011;9(9):673-4
  • Functional architecture of Weibel-Palade bodies
    Valentijn KM, Sadler JE, Valentijn JA, Voorberg J, Eikenboom J
    Blood 2011 May 12;117(19):5033-43
  • Redeeming ristocetin
    Sadler JE
    Blood 2010 Jul 15;116(2):155-6
  • Antibody-mediated thrombotic disorders: thrombotic thrombocytopenic purpura and heparin-induced thrombocytopenia
    Sadler JE, Poncz M
    In: Williams Hematology, Eighth Edition (K Kaushansky, MA Lichtman, E Beutler, TJ Kipps, U Seligsohn, JT Prchal, eds) McGraw-Hill, New York, 2010; 2163-2183
  • Low von Willebrand factor: sometimes a risk factor and sometimes a disease
    Sadler JE
    Hematology Am Soc Hematol Educ Program 2009:106-12
  • von Willebrand factor assembly and secretion
    Sadler JE
    J Thromb Haemost 2009 Jul;7 Suppl 1:24-7
  • Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines
    Nichols WL, Rick ME, Ortel TL, Montgomery RR, Sadler JE, Yawn BP, James AH, Hultin MB, Manco-Johnson MJ, Weinstein M
    Am J Hematol 2009 Jun;84(6):366-70
  • Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
    McCrae KR, Sadler JE, Cines D
    In: Hematology: Basic Principles and Practice, Fifth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, LE Silberstein, P McGlave, HE Heslop, eds) Elsevier Churchill Livingstone, Philadelphia, 2009; 2099-2111
  • Von Willebrand disease: clinical aspects and therapy
    White GC II, Sadler JE
    In: Hematology: Basic Principles and Practice, Fifth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, LE Silberstein, P McGlave, HE Heslop, eds) Elsevier Churchill Livingstone, Philadelphia, 2009; 1961-1972
  • Enteropeptidase, a type II transmembrane serine protease
    Zheng XL, Kitamoto Y, Sadler JE
    Front Biosci (Elite Ed) 2009 Jun 1;1:242-9
  • Von Willebrand factor content in Alphanate (Laurence J. Logan) – reply
    Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL, Rick ME, Sadler JE, Weinstein M, Yawn BP
    Haemophilia 2009;15:370-1
  • Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura
    Sadler JE
    Blood 2008 Jul 1;112(1):11-8
  • Pathogenesis of thrombotic microangiopathies
    Zheng XL, Sadler JE
    Annu Rev Pathol 2008 Mar 3;249-277
  • Diagnosing VWD type 1: when is it useful and when illogical?
    Sadler JE
    Blood 2007;109:4106
  • Interesting variations on how a disease is defined: comparisons of von Willebrand disease and Glanzmann thrombasthenia. Reply to a rebuttal
    Sadler JE
    J Thromb Haemost 2007 Mar;5(3):649-51
  • VWD data worth 10,000 words
    Sadler JE
    Blood 2007;109:3
  • Thrombotic thrombocytopenic purpura: a moving target
    Sadler JE
    Hematology Am Soc Hematol Educ Program 2006;:415-20
  • Thrombotic microangiopathies: thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome
    McCrae KR, Cines DB, Sadler JE
    In: Thrombocytopenia (KR McCrae, ed) Taylor and Francis, London, UK, 2006; 247-265
  • Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
    Zheng XL, Sadler JE
    In: Clinical Hematology (NS Young, SL Gerson, KA High, eds) Mosby Elsevier, Philadelphia, 2006; 802-813
  • von Willebrand disease
    Sadler JE, Blinder M
    In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, Fifth Edition (RW Colman, VJ Marder, AW Clowes, JN George, and SZ Goldhaber, eds) Lippincott Williams & Wilkins, Philadelphia, 2006; 905-921
  • Antibody-mediated thrombotic disorders: thrombotic thrombocytopenic purpura and heparin induced thrombocytopenia
    Sadler JE, Poncz M
    In: Williams Hematology, Seventh Edition (MA Lichtman, E Beutler, K Kaushansky, TJ Kipps, U Seligsohn, JT Prchal, eds) McGraw-Hill, New York, 2006; 2031-2054
  • von Willebrand factor: two sides of a coin
    Sadler JE
    J Thromb Haemost 2005 Aug;3(8):1702-9
  • New concepts in von Willebrand disease
    Sadler JE
    Annu Rev Med 2005;56:173-91
  • Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
    McCrae KR, Sadler JE, Cines D
    In: Hematology: Basic Principles and Practice, Fourth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, HJ Cohen, LE Silberstein, P McGlave, eds) Elsevier Churchill Livingstone, Philadelphia, 2005; 2287-2304
  • Von Willebrand disease: Clinical aspects and therapy
    White GC II, Sadler JE
    In: Hematology: Basic Principles and Practice, Fourth Edition (R Hoffman, EJ Benz, SJ Shattil, B Furie, HJ Cohen, LE Silberstein, P McGlave, eds) Elsevier Churchill Livingstone, Philadelphia, 2005; 2121-2136
  • Recent advances in thrombotic thrombocytopenic purpura
    Sadler JE, Moake JL, Miyata T, George JN
    Hematology (Am Soc Hematol Educ Program) 2004;:407-23
  • Proteomics, genomics and the future of medical education
    Pike LJ, Sadler JE
    Mo Med 2004 Sep-Oct;101(5):496-9
  • Slippery criteria for von Willebrand disease type 1
    Sadler JE
    J Thromb Haemost 2004 Oct;2(10):1720-3
  • Medicine: K is for koagulation
    Sadler JE
    Nature 2004 Feb 5;427(6974):493-4
  • ADAMTS13: von Willebrand factor-cleaving protease
    Chung DW, Sadler JE
    In: Handbook of Proteolytic Enzymes, Second Edition (AJ Barrett, ND Rawlings, and JF Woessner, Jr, eds) Elsevier Academic Press, London, 2004; 747-749
  • Enteropeptidase
    Sadler JE
    In: Handbook of Proteolytic Enzymes, Second Edition (AJ Barrett, ND Rawlings, and JF Woessner, Jr, eds) Elsevier Academic Press, London, 2004; 1513-1517
  • Aortic stenosis, von Willebrand factor, and bleeding
    Sadler JE
    N Engl J Med 2003 Jul 24;349(4):323-5
  • Structural biology. A menage a trois in two configurations
    Sadler JE
    Science 2003 Jul 11;301(5630):177-9
  • A broader look at thrombotic microangiopathy and ADAMTS13
    Sadler JE
    Blood 2003;102:2
  • A new name in thrombosis, ADAMTS13
    Sadler JE
    Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11552-4
  • Biomedicine. Contact--how platelets touch von Willebrand factor
    Sadler JE
    Science 2002 Aug 16;297(5584):1128-9
  • Platelets: thrombotic thrombocytopenic purpura
    George JN, Sadler JE, Lammle B
    Hematology (Am Soc Hematol Educ Program) 2002;315-34
  • Does VWF bind collagen after all?
    Sadler JE
    Blood 2002;99:3591
  • ADAMTS13 and TTP
    Zheng X, Majerus EM, Sadler JE
    Curr Opin Hematol 2002 Sep;9(5):389-94
  • More to TTP than VWFCP
    Sadler JE
    Blood 2002;99:397-398
  • von Willebrand factor
    Sadler JE
    In: Encyclopedia of Molecular Medicine (TE Creighton, ed) John Wiley & Sons, New York, 2002; 3392-3395
  • Report on the workshop: Von Willebrand factor and Thrombotic Thrombocytopenic Purpura
    Moake JL, Sadler JE, Mannucci P, Ganguly P
    Am J Hematol 2001 Oct;68(2):122-6
  • Boosting a natural anticoagulant
    Sadler JE
    Blood 2001;97:1523-1524
  • von Willebrand disease
    Sadler JE
    In: The Metabolic and Molecular Bases of Inherited Disease, Eighth Edition (CR Scriver, AL Beaudet, WS Sly, and D Valle, eds) McGraw-Hill Book Co, New York, 2001; 4415-4431
  • Hemophilia A, hemophilia B, and von Willebrand disease
    Sadler JE, and Davie EW
    In: The Molecular Basis of Blood Diseases, Third Edition (G Stamatoyannopoulos, PW Majerus, R M Perlmutter, and H Varmus, eds) WB Saunders Co, Philadelphia 2001; 680-718
  • von Willebrand disease
    Sadler JE, Blinder M
    In: Hemostasis and Thrombosis Basic Principles and Clinical Practice, Fourth Edition (RW Colman, J Hirsh, VJ Marder, AW Clowes, and JN George, eds) Lippincott Williams & Wilkins, Philadelphia 2001; 825-837
  • Biochemistry and genetics of von Willebrand factor
    Sadler JE
    Annu Rev Biochem 1998;67:395-424
  • Enteropeptidase
    Lu D, Sadler JE
    In: Handbook of Proteolytic Enzymes (AJ Barrett, ND Rawlings, and JF Woessner, Jr, eds) Academic Press Ltd, London, 1998; 50-54
  • Thrombomodulin structure and function
    Sadler JE
    Thromb Haemost 1997 Jul;78(1):392-5
  • Combined factors V and VIII deficiency climbs onto the map [editorial]
    Sadler JE
    J Clin Invest 1997 Feb 15;99(4):555-6
  • Molecular mechanism and classification of von Willebrand disease
    Sadler JE, Matsushita T, Dong Z, Tuley EA, Westfield LA
    Thromb Haemost 1995 Jul;74(1):161-6
  • von Willebrand disease
    Sadler JE
    In: The Metabolic and Molecular Basis of Inherited Disease, Seventh Edition (CR Scriver, AL Beaudet, WS Sly, and D Valle, eds) McGraw-Hill Book Co, New York 1995; 3269-3287
  • Commentary: a new classification for von Willebrand disease
    Sadler JE, Gralnick HR
    Blood 1994 Aug 1;84(3):676-9
  • von Willebrand's factor and von Willebrand's disease
    Matsushita T, Dong Z, Sadler JE
    Curr Opin Hematol 1994 Sep;1(5):362-8
  • The molecular basis of thrombomodulin function
    Lentz SR, Sadler JE
    In: Thrombomodulin (JC Giddings, ed) RG Landes Co, Austin, TX, 1994; 91-120
  • von Willebrand disease
    Sadler JE
    In: Haemostasis and Thrombosis, Third Edition (AL Bloom, CD Forbes, DP Thomas, and EGD Tuddenham, eds) Churchill-Livingstone, Edinburgh 1994; 843-857
  • Hemophilia A, hemophilia B, and von Willebrand disease
    Sadler JE, Davie EW
    In: Molecular Basis of Blood Diseases, Second Edition (G Stamatoyannopoulos, AW Nienhuis, PW Majerus, and H Varmus, eds) WB Saunders Co, Philadelphia 1994; 657-700
  • Structure-function relationships of the thrombin-thrombomodulin interaction
    Sadler JE, Lentz SR, Sheehan JP, Tsiang M, Wu Q
    Haemostasis 1993 Mar;23 Suppl 1:183-93
  • von Willebrand factor
    Sadler JE
    J Biol Chem 1991 Dec 5;266(34):22777-80
  • Molecular biology of von Willebrand factor
    Sadler JE, Mancuso DJ, Randi AM, Tuley EA, Westfield LA
    Ann N Y Acad Sci 1991;614:114-24
  • Recombinant DNA methods in hemophilia A: carrier detection and prenatal diagnosis
    Sadler JE
    Semin Thromb Hemost 1990 Oct;16(4):341-7
  • The multilocus Charcot-Marie-Tooth syndrome
    Lebo RV, Conneally PM, Flandermeyer RR, Christian C, Bolbus MS, Lovelace RE, Anderson LA, Chance PF, Bird TD, Bruce BD, Slotnick RN, Dyckoff D, Sadler JE, Carver V, Schonberg SA, Fowler WM, Ionasescu V, Kadasi L, Dyck PJ
    In: Charcot-Marie-Tooth Disorders Pathophysiology, Molecular Genetics, and Therapy (RE Lovelace and HK Shapiro, eds) Neurology and Neurobiology 53, Alan R Liss, New York 1990; 307-334
  • Molekularbiologie des von-Willebrand-Faktors [German]
    Mancuso DJ, Sadler JE
    Hämostaseologie 1989;9:122-129
  • Von Willebrand disease
    Sadler JE
    In: The Metabolic Basis of Inherited Disease, Sixth Edition (CR Scriver, AL Beaudet, WS Sly, and D Valle, eds) McGraw-Hill Book Co, New York 1989; 2171-2188
  • Molecular biology of von Willebrand factor
    Sadler JE
    In: Coagulation and Bleeding Disorders The Role of Factor VIII and von Willebrand Factor (TS Zimmerman and Z Ruggeri, eds) Marcel Dekker, Inc, New York 1989; 117-135
  • The molecular biology of von Willebrand factor
    Sadler JE
    In Thrombosis and Haemostasis 1987 (M Verstraete, J Vermylen, R Lijnen, and J Arnout, eds) International Society on Thrombosis and Haemostasis and Leuven University Press, Leuven, Belgium 1987; 61-79
  • Hemophilia A, hemophilia B, and von Willebrand's disease
    Sadler JE, Davie EW
    In: Molecular Basis of Blood Diseases (G Stamatoyannopoulos, AW Nienhuis, P Leder, and PW Majerus, eds) WB Saunders Co, Philadelphia 1987; 575-630
  • Cloning of cDNA and genomic DNA for human von Willebrand factor
    Sadler JE, Shelton-Inloes BB, Sorace JM, Titani K
    Cold Spring Harb Symp Quant Biol 1986;51 Pt 1:515-23
  • Characterization of two cDNAs coding for human von Willebrand factor and the implications for biosynthesis and evolution
    Sadler JE, Shelton-Inloes BB, Sorace JM, Harlan JM, Titani K, Davie EW
    In: Factor VIII/von Willebrand Factor: Biological and Clinical Advances  (N Ciavarella, ZM Ruggeri, and TS Zimmerman, eds) Wichtig Editore, Milan 1986; 103-109
  • Cloning and structural characterization of the gene for human plasminogen
    Sadler JE, Malinowski DP, Davie EW
    In: Progress in Fibrinolysis, Vol 7 (JF Davidson, MB Donati, and S Coccheri, eds) Churchill Livingstone, Edinburgh 1985; 201-204
  • Biosynthesis of glycoproteins Formation of O-linked oligosaccharides
    Sadler JE
    In: Biology of Carbohydrates, Vol 2 (V Ginsburg and PW Robbins, eds) John Wiley and Sons, New York 1984; 199-288
  • Purification of mammalian glycosyltransferases
    Sadler JE, Beyer TA, Oppenheimer CL, Paulson JC, Prieels JP, Rearick JI, Hill RL
    Methods Enzymol 1982;83:458-514
  • Affinity chromatography of glycosyltransferases
    Sadler JE, Beyer TA, Hill RL
    J Chromatogr 1981 Oct 23;215:181-94
  • Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships
    Beyer TA, Sadler JE, Rearick JI, Paulson JC, Hill RL
    Adv Enzymol Relat Areas Mol Biol 1981;52:23-175
  • Glycosyltransferases in oligosaccharide biosynthesis and their use in structure-function analysis of glycoproteins
    Hill RL, Beyer TA, Paulson JC, Prieels J-P, Rearick JI, Sadler JE
    In: (IUPAC) Frontiers of Bioorganic Chemistry and Molecular Biology (SN Ananchenko, ed) Pergamon Press, New York 1980; 63-71
  • Glycosyl transferases in glycoconjugate biosynthesis and their use in assessing oligosaccharide structure and function
    Hill RL, Beyer TA, Rearick JI, Sadler JE, Prieels J-P, Paulson JC
    In: Glycoconjugates: Proceedings of the Fifth International Symposium, Kiel, Federal Republic of Germany, (R Schauer, P Boer, E Buddecke, MF Kramer, JFG Vliegenthart, and H Wiegandt, eds) Georg Thieme Publishers, Stuttgart, September 1979; 274-275
  • Purification of two sialyltransferase activities from porcine submaxillary glands
    Sadler JE, Rearick JI, Paulson JC, Hill RL
    In: Glycoconjugate Research Proceedings of the Fourth International Symposium on Glycoconjugates (JD Gregory and RW Jeanloz, eds) Academic Press, New York 1979; Vol II: 763-766

Movies, videotapes, etc.

  • Idiopathic thrombocytopenic purpura
    Sadler JE
    In: Protein Epidemiology: Understanding Human Diseases at the Level of Protein Structure and Function (B Dunn, ed.), The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0101281-Sadler)