Clinical Protocols

Oncology
Oncology Clinical Trials

 

Hematology

Click on a protocol's title to view its description in ClinicalTrials.gov.
Click on download to view the protocol (WUSTL key password required).
 
Sort by disease

PI/Contact Disease Protocol (Sponsor) Status Comments
PI: Morey Blinder
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550
Autoimmune Hemolytic Anemia A Phase 2 Study of INCB050465 in Participants with Autoimmune Hemolytic Anemia Open
PI: Morey Blinder
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550
Sickle Cell Disease A Phase 3 Study of GBTT440 Administered Orally to Patients with Sickle Cell Disease, GBT_HOPE Enrollment on hold
PI: Morey Blinder
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550
Thrombocytopenia Avatrombopag for the Treatment of Thrombocytopenia in Adults Scheduled for a Surgical Procedure Open
PI: Elaine Majerus
Contact: Vanetta Worthy
worthyv@wustl.edu
314-362-9998
Atypical HUS Atypical Hemolytic-Uremic Syndrome (aHUS) Registry Open to enrollment Atypical HUS
PI: Elaine Majerus
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-9998
Banking Laboratory Studies Blood Acquistion for Investigation of Thrombotic Disorders Open Thrombosis Banking
PI: Elaine Majerus
Contact: Bill Berger
bergerwb@wustl.edu
314-362-9996
Bleeding and clotting disorders CDC Community Counts: Surveillance Project for Patients with Bleeding and Blood Clotting Disorders Open
PI: Elaine Majerus
Contact: Vanetta Worthy
worthyv@wustl.edu
314-362-9998
PNH Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry Open to enrollment PNH Registry
PI: Elaine Majerus
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-0156
Sickle Cell Disease A Phase II Trial of Regadenoson in Sickle Cell Anemia Open to enrollment HbSS and S Beta Null
PI: Elaine Majerus
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550
Hemophilia A A Phase 3 Study of Valoctocogene Roxaparvovec in Hemophilia A Patients Open Male patients only
PI: Elaine Majerus
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550
Hemophilia A A Phase 3 Study of Valoctocogene Roxaparvovec in Hemophilia A Patients at a Dose of 4E13 vg/kg Open Male patients only
PI: Elaine Majerus
Contact: Bill Berger
bergerwb@wustl.edu
314-362-9996
Hemophilia/Bleeding American Thrombosis and Hemostasis Network Data Collection Open
PI: Elaine Majerus
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-0156
Sickle Cell Disease Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD) Ongoing; closed to enrollment Hb SS and S Beta Null
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myelofibrosis A Phase 2 Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis Open and enrolling
download
MF patients with suboptimal response to ruxolitinib
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis A Phase 2 Study of Pacritinib in Myelofibrosis Patients Previously Treated with Ruxolitinib Suspended to enrollment
download
Prior ruxolitinib treatment failure/intolerance and palpable splenomegaly
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
CNL/aCML Ruxolitinib Phosphate in Treating Patients With Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia Ongoing; closed to enrollment  
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis Extended Access of Momelotinib in Adults with Myelofibrosis (352-4365) Enrolling by invitation only
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myelofibrosis Pevondistat in Combination with Ruxolitinib in Myelofibrosis Patients Open to enrollment
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myelofibrosis A Phase 2 Dose Expansion Study of CPI-0610 with and without Ruxolitinib in Patients with Myelofibrosis (MANIFEST) Open
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis Phase 2 Study of KRT-232 in Myelofibrosis Patients Who Failed Prior JAK Inhibitor Open to enrollment
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-747-7960
Myelofibrosis Phase 3 Study of Fedratinib in Myelofibrosis Patients Previously Treated with Ruxolitinib Open
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myelofibrosis and Essential Thrombocythemia Myelofibrosis and Essential Thrombocythemia Observational Study (MOST) Ongoing; closed to enrollment
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myeloid/Lymphoid Neoplasms A Phase 2, Open-Label, Monotherapy, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement Open
download
Patients with 8p11 (FGFR1) rearrangement
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Polycythemia Vera Phase 2 Study of KRT-232 Vs. Ruxolitinib in Phlebotomy-Dependent Polycythemia Vera Patients Open
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Systemic Mastocytosis A Phase 2 study of Avapritinib in Patients with Advanced Systemic Mastocytosis (BLU-285-2202) Pending
download
PI: Kristen Sanfilippo
Contact: Andrew Maus
amaus@wustl.edu
314-747-7813
Blood Clots in Cancer Patients Direct Oral Anticoagulants vs. Low Molecular Weight Heparin +/- Warfarin for Venous Thromboemboli in Cancer Patients (CANVAS) Open
download
PI: Kristen Sanfilippo
Contact: Andrew Maus
amaus@wustl.edu
314-747-7813
Blood Clots in Cancer Patients A Phase 3 Study Evaluating Apixaban for Secondary Prevention of Cancer Related Venous Thrombosis (ACCRU-SC-1601) Open
download
PI: Amy Zhou
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myelodysplastic Syndrome A Phase 3 Study of Roxadustat for Anemia in MDS patients Open to enrollment
download