Grant Challen.jpg

Grant A. Challen, PhD

Associate Professor
Department of Medicine
Oncology Division
Stem Cell Biology

Research Interests

  • Hematopoietic stem cells
  • Leukemia stem cells
  • Epigenetic modifications


  • 314-362-0987 (tel)
  • 314-362-1953 (fax)
  • Room 744 Southwest Tower (lab)
  • Washington University School of Medicine
    Division of Oncology
    Campus Box 8056
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Challen Lab Website

Invited Publications

  • Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis
    Challen GA
    Cell Stem Cell 2017 Jan 5;20(1):7-8
  • The Epigenetic Basis of Hematopoietic Stem Cell Aging
    Kramer A, Challen GA
    Semin Hematol 2017 Jan;54(1):19-24
  • Inflammatory Signals in HSPC Development and Homeostasis: Too Much of a Good Thing?
    Luis TC, Tremblay CS, Manz MG, North TE, King KY, Challen GA
    Exp Hematol 2016 Oct;44(10):908-12
  • DNA Methylation in Normal and Malignant Hematopoiesis
    Celik H, Kramer A, Challen GA
    Int J Hematol 2016 Jun;103(6):617-626
  • Two New Routes to Make Blood: Hematopoietic Specification From Pluripotent Cell Lines Versus Reprogramming of Somatic Cells
    Singbrant S, van Galen P, Lucas D, Challen G, Rossi DJ, Daley GQ
    Exp Hematol 2015 Sep;43(9):756-759
  • Isolation and Characterization of Mouse Side Population Cells
    Ergen AV, Jeong M, Lin KK, Challen GA, Goodell MA
    Methods Mol Biol 2013;946:151-62
  • Hematopoietic Stem Cell Properties, Markers, and Therapeutics
    Lin KK, Challen GA, Goodell MA
    In: Principles of Regenerative Medicine. Elsevier/Academic Press 2011, pp 273-284
  • Bridge Over Troubled Stem Cells
    Challen GA, Goodell MA
    Mol Ther 2011 Oct;19(10):1756-8
  • The Potential of the Side Population in Regenerative Nephrology
    Little MH, Challen GA
    In: Regenerative Nephrology (Goligorsky, ed), Academic Press 2011
  • Hematopoietic Stem Cell Characterization and Isolation
    Rossi L, Challen GA, Sirin O, Lin KK, Goodell MA
    Methods Mol Biol 2011;750:47-59
  • Where New Approaches Can Stem From: Focus on Stem Cell Identification
    Adams V, Challen GA, Zuba-Surma E, Ulrich H, Vereb G, Tarnok A
    Cytometry A 2009 Jan;75(1):1-3
  • Mouse Hematopoietic Stem Cell Identification and Analysis
    Challen GA, Boles N, Lin KK, Goodell MA
    Cytometry A 2009 Jan;75(1):14-24
  • A Side Order of Stem Cells: The SP Phenotype
    Challen GA, Little MH
    Stem Cells 2006 Jan;24(1):3-12
  • Post-Transcription Regulation of mRNA and Hormone Synthesis and Release at the Anterior Pituitary Gland: Information Derived From the Recovery of Pituitary Gonadotrope Cell Function After Therapy With a GnRH Agonist
    D’Occhio MJ, Challen GA, Braga DPAF, Aspden WJ, Trigg TE
    Ann Rev Bio Sci 2000;2:91-112