Hematology Division
Alphabetical list (active faculty):   
Jaehyung (Gus) Cho

Jaehyung (Gus) Cho, PhD


Department of Medicine

Hematology Division

Department of Pathology & Immunology

Research Interests

  • Platelet
  • Neutrophil
  • Thrombosis
  • Inflammation
  • Intravital microscopy


  • 314-362-8804 (office)
  • 314-362-8826 (fax)
  • Division of Hematology
    Mail Stop 8125-0020-08
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 8804A, Clinical Sciences Research Building (office)
  • Room 8804/8808, Clinical Sciences Research Building (lab)

Research Articles

  • A Critical Role for ERO1alpha in Arterial Thrombosis and Ischemic Stroke
    Jha V, Xiong B, Kumari T, Brown G, Wang J, Kim K, Lee J, Asquith N, Gallagher J, Asherman L, Lambert T, Bai Y, Du X, Min JK, Sah R, Javaheri A, Razani B, Lee JM, Italiano JE, Cho J
    Circ Res 2023 May 26;132(11):e206-e222
  • Endothelial PTP4A1 Mitigates Vascular Inflammation Via USF1/A20 Axis-Mediated NF-KappaB Inactivation
    Cho MJ, Lee DG, Lee JW, Hwang B, Yoon SJ, Lee SJ, Park YJ, Park SH, Lee HG, Kim YH, Lee CH, Lee J, Lee NK, Han TS, Cho HS, Moon JH, Lee GS, Bae KH, Hwang GS, Lee SH, Chung SJ, Shim S, Cho J, Oh GT, Kwon YG, Park JG, Min JK
    Cardiovasc Res 2023 May 22;119(5):1265-1278
  • Protein Disulfide Isomerase A1 as a Novel Redox Sensor in VEGFR2 Signaling and Angiogenesis
    Nagarkoti S, Kim YM, Ash D, Das A, Vitriol E, Read TA, Youn SW, Sudhahar V, McMenamin M, Hou Y, Boatwright H, Caldwell R, Essex DW, Cho J, Fukai T, Ushio-Fukai M
    Angiogenesis 2023 Feb;26(1):77-96
  • Neutrophil DREAM Promotes Neutrophil Recruitment in Vascular Inflammation
    Li J, Kumari T, Barazia A, Jha V, Jeong SY, Olson A, Kim M, Lee BK, Manickam V, Song Z, Clemens R, Razani B, Kim J, Dinauer MC, Cho J
    J Exp Med 2022 Jan 3;219(1):20211083
  • Shear and Integrin Outside-In Signaling Activate NADPH-Oxidase 2 to Promote Platelet Activation
    Xu Z, Liang Y, Delaney MK, Zhang Y, Kim K, Li J, Bai Y, Cho J, Ushio-Fukai M, Cheng N, Du X
    Arterioscler Thromb Vasc Biol 2021 May 5;41(5):1638-1653
  • Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma Phagocytophilum Asp14 Enables Pathogen Infection
    Green RS, Naimi WA, Oliver LD Jr, O'Bier N, Cho J, Conrad DH, Martin RK, Marconi RT, Carlyon JA
    mBio 2020 Jan 28;11(1)
  • Repurposing Pyridoxamine for Therapeutic Intervention of Intravascular Cell-Cell Interactions in Mouse Models of Sickle Cell Disease
    Li J, Jeong SY, Xiong B, Tseng A, Mahon AB, Isaacman S, Gordeuk VR, Cho J
    Haematologica 2020 Oct 1;105(10):2407-2419 (Commentary in Haematologica 2020;105(10):2348-2350)
  • Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibalpha-Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions
    Li J, Kim K, Jeong SY, Chiu J, Xiong B, Petukhov PA, Dai X, Li X, Andrews RK, Du X, Hogg PJ, Cho J
    Circulation 2019 Mar 5;139(10):1300-1319
  • YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6
    Lv Y, Kim K, Sheng Y, Cho J, Qian Z, Zhao YY, Hu G, Pan D, Malik AB, Hu G
    Circ Res 2018 Jun 22;123(1):43-56
  • Myeloperoxidase Negatively Regulates Neutrophil-Endothelial Cell Interactions by Impairing AlphaMbeta2 Integrin Function in Sterile Inflammation
    Tseng A, Kim K, Li J, Cho J
    Front Med (Lausanne) 2018 May 4;5:134
  • Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence
    Kim YM, Youn SW, Sudhahar V, Das A, Chandhri R, Cuervo Grajal H, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M
    Cell Rep 2018 Jun 19;23(12):3565-3578
  • DREAM Plays an Important Role in Platelet Activation and Thrombogenesis
    Kim K, Tseng A, Barazia A, Italiano JE, Cho J
    Blood 2017 Jan 12;129(2):209-225
  • ARQ 092, an Orally-Available, Selective AKT Inhibitor, Attenuates Neutrophil-Platelet Interactions in Sickle Cell Disease
    Kim K, Li J, Barazia A, Tseng A, Youn SW, Abbadessa G, Yu Y, Schwartz B, Andrews RK, Gordeuk VR, Cho J
    Haematologica 2017 Feb;102(2):246-259
  • Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis
    Delaney MK, Kim K, Estevez B, Xu Z, Stojanovic-Terpo A, Shen B, Ushio-Fukai M, Cho J, Du X
    Arterioscler Thromb Vasc Biol 2016 May;36(5):846-54
  • Endothelial p110gammaPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular Injury
    Huang X, Dai Z, Cai L, Sun K, Cho J, Albertine KH, Malik AB, Schraufnagel DE, Zhao YY
    Circulation 2016 Mar 15;133(11):1093-103
  • Signaling-Mediated Cooperativity Between Glycoprotein Ib-IX and Protease-Activated Receptors in Thrombin-Induced Platelet Activation
    Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X
    Blood 2016 Feb 4;127(5):626-36
  • Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization Via Chaperone and Transcription Factor Function
    Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney RD, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman JW, Shantikumar S, Angelini GD, Emanueli C, Ushio-Fukai M, Fukai T
    Sci Rep 2015 Oct 6;5:14780
  • Hydroxyurea With AKT2 Inhibition Decreases Vaso-Occlusive Events in Sickle Cell Disease Mice
    Barazia A, Li J, Kim K, Shabrani N, Cho J
    Blood 2015 Nov 26;126(22):2511-7
  • NOX2 Is Critical for Heterotypic Neutrophil-Platelet Interactions During Vascular Inflammation
    Kim K, Li J, Tseng A, Andrews RK, Cho J
    Blood 2015 Oct 15;126(16):1952-64
  • Scalable Generation of Universal Platelets From Human Induced Pluripotent Stem Cells
    Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R
    Stem Cell Reports 2014 Nov 11;3(5):817-31
  • Agonist-Induced Platelet Procoagulant Activity Requires Shear and a Rac1-Dependent Signaling Mechanism
    Delaney MK, Liu J, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X
    Blood 2014 Sep 18;124(12):1957-67
  • Prevention of Vascular Inflammation by Nanoparticle Targeting of Adherent Neutrophils
    Wang Z, Li J, Cho J, Malik AB
    Nat Nanotechnol 2014 Mar;9(3):204-10
  • Neutrophil AKT2 Regulates Heterotypic Cell-Cell Interactions During Vascular Inflammation
    Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho J
    J Clin Invest 2014 Apr;124(4):1483-96
  • G Protein-Dependent Basal and Evoked Endothelial Cell VWF Secretion
    Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD
    Blood 2014 Jan 16;123(3):442-50
  • A Directional Switch of Integrin Signalling and a New Anti-Thrombotic Strategy
    Shen B, Zhao X, O'Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SC, Du X
    Nature 2013 Nov 7;503(7474):131-5
  • Platelet Protein Disulfide Isomerase Is Required for Thrombus Formation but Not for Hemostasis in Mice
    Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J
    Blood 2013 Aug 8;122(6):1052-61
  • Real-Time Imaging of Heterotypic Platelet-Neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
    Kim KH, Barazia A, Cho J
    J Vis Exp 2013 Apr 2;(74)
  • Extracellular Protein Disulfide Isomerase Regulates Ligand-Binding Activity of AlphaMbeta2 Integrin and Neutrophil Recruitment During Vascular Inflammation
    Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J
    Blood 2013 May 9;121(19):3789-800, S1-15
  • Protein Disulfide Isomerase Capture During Thrombus Formation in Vivo Depends on the Presence of Beta3 Integrins
    Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B
    Blood 2012 Jul 19;120(3):647-55
  • Platelets Generated From Human Embryonic Stem Cells Are Functional in Vitro and in the Microcirculation of Living Mice
    Lu SJ, Li F, Yin H, Feng Q, Kimbrel EA, Hahm E, Thon JN, Wang W, Italiano JE, Cho J, Lanza R
    Cell Res 2011 Mar;21(3):530-45
  • Alpha 1,3 Fucosyltransferases Are Master Regulators of Prostate Cancer Cell Trafficking
    Barthel SR, Wiese GK, Cho J, Opperman MJ, Hays DL, Siddiqui J, Pienta KJ, Furie B, Dimitroff CJ
    Proc Natl Acad Sci U S A 2009 Nov 17;106(46):19491-6
  • A Critical Role for Extracellular Protein Disulfide Isomerase During Thrombus Formation in Mice
    Cho J, Furie BC, Coughlin SR, Furie B
    J Clin Invest 2008 Mar;118(3):1123-31
  • Role of Fibronectin Assembly in Platelet Thrombus Formation
    Cho J, Mosher DF
    J Thromb Haemost 2006 Jul;4(7):1461-9
  • Impact of Fibronectin Assembly on Platelet Thrombus Formation in Response to Type I Collagen and Von Willebrand Factor
    Cho J, Mosher DF
    Blood 2006 Oct 1;108(7):2229-36
  • Characterization of Fibronectin Assembly by Platelets Adherent to Adsorbed Laminin-111
    Cho J, Mosher DF
    J Thromb Haemost 2006 May;4(5):943-51
  • Enhancement of Thrombogenesis by Plasma Fibronectin Cross-Linked to Fibrin and Assembled in Platelet Thrombi
    Cho J, Mosher DF
    Blood 2006 May 1;107(9):3555-63
  • Fibrin but Not Adsorbed Fibrinogen Supports Fibronectin Assembly by Spread Platelets. Effects of the Interaction of AlphaIIb Beta3 With the C Terminus of the Fibrinogen Gamma-Chain
    Cho J, Degen JL, Coller BS, Mosher DF
    J Biol Chem 2005 Oct 21;280(42):35490-8
  • The Antithrombotic Efficacy of AT-1459, a Novel, Direct Thrombin Inhibitor, in Rat Models of Venous and Arterial Thrombosis
    Cho JH, Yun CH, Seo HS, Koga T, Dan T, Koo BA, Kim HY
    Thromb Haemost 2001 Dec;86(6):1512-20
  • In Vitro and in Vivo Studies of AT-1362, a Newly Synthesized and Orally Active Inhibitor of Thrombin
    Cho J, Seo H, Yun C, Koo B, Yoshida S, Koga T, Dan T, Kim H
    Thromb Res 2000 Oct 1;100(1):97-107

Invited Reviews and Commentaries