Jaebok Choi, PhD
Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology
Research Interests
- Allogeneic hematopoietic stem cell transplantation
- GvHD
- IFNγR
- IL6R
- JAK-STAT signaling
Contact
- 314-362-9349 (office)
- 314-273-0153 (lab)
- 314-362-1953 (fax)
- jchoi25@wustl.edu
- Division of Oncology
Mail Stop 8007-0057-07
Washington University
660 South Euclid Avenue
St. Louis, MO 63110
- Room 731 Southwest Tower (office)
- Room 724 Southwest Tower (lab)
Peer-reviewed Manuscripts
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Restoring NK Cell Functions in AML Relapse
Kim S, Choi J
Blood 2022 Dec 29;140(26):2765-2766
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S100A9 Up-Regulated by IFNGR Signaling Blockade Functions as a Novel GvHD Suppressor Without Compromising GvL in Mice
Kim S, Lim S, Kim B, Ritchey J, Vij K, Prior J, Marsala L, Stoner A, Gao F, Achilefu S, Cooper ML, DiPersio JF, Choi J
Blood 2022 Dec 7:blood2021012687; [ahead of print]
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Editorial: Interferons and GvHD
Kim B, Choi J
Front Immunol 2022 Feb 3;13:853567
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Baricitinib Prevents GvHD by Increasing Tregs Via JAK3 and Treats Established GvHD by Promoting Intestinal Tissue Repair Via EGFR
Kim S, Ashami K, Lim S, Staser K, Vij K, Santhanam S, Ritchey J, Peterson S, Gao F, Ciorba MA, Cooper ML, DiPersio JF, Choi J
Leukemia 2022 Jan;36(1):292-295
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Antibody-Drug Conjugates Plus Janus Kinase Inhibitors Enable MHC-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation
Persaud SP, Ritchey JK, Kim S, Lim S, Ruminski PG, Cooper ML, Rettig MP, Choi J, DiPersio JF
J Clin Invest 2021 Dec 15;131(24):e145501
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Targeting Histone Deacetylases to Modulate Graft-Versus-Host Disease and Graft-Versus-Leukemia
Kim S, Santhanam S, Lim S, Choi J* (* senior author)
Int J Mol Sci 2020 Jun 16;21(12)
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A Phase 1 Trial of Itacitinib, a Selective JAK1 Inhibitor, in Patients With Acute Graft-Versus-Host Disease
Schroeder MA, Khoury HJ, Jagasia M, Ali H, Schiller GJ, Staser K, Choi J, Gehrs L, Arbushites MC, Yan Y, Langmuir P, Srinivas N, Pratta M, Perales MA, Chen YB, Meyers G, DiPersio JF
Blood Adv 2020 Apr 28;4(8):1656-1669
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Insights Into the Role of the JAK/STAT Signaling Pathway in Graft-Versus-Host Disease
Abboud R, Choi J, Ruminski P, Schroeder MA, Kim S, Abboud CN, DiPersio JF
Ther Adv Hematol 2020 Jun 2;11:2040620720914489
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Selective Targeting of Alpha4beta1 Integrin Attenuates Murine Graft Versus Host Disease
Alahmari B, Cooper ML, Vij K, Ritchey J, Ruminski P, Gao F, Choi J*, DiPersio JF* (* co-senior author)
Leukemia 2020 Nov;34(11):3100-3104
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Targeting IFNGR/IL6R or Downstream JAK1/JAK2 to Control GvHD
Ashami K, DiPersio JF, Choi J* (* senior author)
Oncotarget 2018 Nov 6;9(87):35721-35722
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Selective Targeting of Histone Modification Fails to Prevent Graft Versus Host Disease After Hematopoietic Cell Transplantation
Alahmari B, Cooper M, Ziga E, Ritchey J, DiPersio JF, Choi J* (* senior author)
PLoS One 2018 Nov 19;13(11):e0207609
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Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-Tolerance
Perry JSA, Russler-Germain EV, Zhou YW, Purtha W, Cooper ML, Choi J, Schroeder MA, Salazar V, Egawa T, Lee BC, Abumrad NA, Kim BS, Anderson MS, DiPersio JF, Hsieh CS
Immunity 2018 May 15;48(5):923-936
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Baricitinib-Induced Blockade of Interferon Gamma Receptor and Interleukin-6 Receptor for the Prevention and Treatment of Graft-Versus-Host Disease
Choi J, Cooper ML, Staser K, Ashami K, Vij KR, Wang B, Marsala L, Niswonger J, Ritchey J, Alahmari B, Achilefu S, Tsunoda I, Schroeder MA, DiPersio JF
Leukemia 2018 Nov;32(11):2483-2494
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An "Off-The-Shelf" Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies
Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
Leukemia 2018 Sep;32(9):1970-1983
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The Role of Janus Kinase Signaling in Graft-Versus-Host Disease and Graft Versus Leukemia
Schroeder MA, Choi J, Staser K, DiPersio JF
Biol Blood Marrow Transplant 2018 Jun;24(6):1125-1134
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OMIP-042: 21-Color Flow Cytometry to Comprehensively Immunophenotype Major Lymphocyte and Myeloid Subsets in Human Peripheral Blood
Staser KW, Eades W, Choi J, Karpova D, DiPersio JF
Cytometry A 2018 Feb;93(2):186-189
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Azacitidine Mitigates Graft-Versus-Host Disease Via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells in Vivo
Cooper ML, Choi J, Karpova D, Vij K, Ritchey J, Schroeder MA, DiPersio JF
J Immunol 2017 May 1;198(9):3746-3754
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Phase I Study of Azacitidine Following Donor Lymphocyte Infusion for Relapsed Acute Myeloid Leukemia Post Allogeneic Stem Cell Transplantation
Ghobadi A, Choi J, Fiala MA, Fletcher T, Liu J, Eissenberg LG, Abboud C, Cashen A, Vij R, Schroeder MA, Pusic I, Stockerl-Goldstein K, Jacoby M, Uy G, DiPersio J, Westervelt P
Leuk Res 2016 Oct;49:1-6
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GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes Following Bone Marrow Transplantation
Becker AM, Callahan DJ, Richner JM, Choi J, DiPersio JF, Diamond MS, Bhattacharya D
PLoS One 2015 Jul 21;10(7):e0133854
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Maintenance Therapy With Decitabine After Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome
Pusic I, Choi J, Fiala MA, Gao F, Holt M, Cashen AF, Vij R, Abboud CN, Stockerl-Goldstein KE, Jacoby MA, Uy GL, Westervelt P, DiPersio JF
Biol Blood Marrow Transplant 2015 Oct;21(10):1761-9
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Pharmacologic Blockade of JAK1/JAK2 Reduces GvHD and Preserves the Graft-Versus-Leukemia Effect
Choi J, Cooper ML, Alahmari B, Ritchey J, Collins L, Holt M, DiPersio JF
PLoS One 2014 Oct 7;9(10):e109799
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IFNγR Signaling as a Therapeutic Target to Prevent GVHD After Allo-HSCT
Choi J, Cooper ML
Austin Journal of Cancer and Clinical Research 2014;1:2-3
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Effect of Epigallocatechin-3-Gallate on Graft-Versus-Host Disease
Choi J, Cooper ML, Ziga ED, Ritchey J, DiPersio JF
Cell Transplant 2014;23(9):1163-6
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F11R Is a Novel Monocyte Prognostic Biomarker for Malignant Glioma
Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH
PLoS One 2013 Oct 11;8(10):e77571
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IFNγR Signaling Mediates Alloreactive T-Cell Trafficking and GVHD
Choi J, Ziga ED, Ritchey J, Collins L, Prior JL, Cooper ML, Piwnica-Worms D, DiPersio JF
Blood 2012 Nov 8;120(19):4093-103
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In Vivo Administration of Hypomethylating Agents Mitigate Graft-Versus-Host Disease Without Sacrificing Graft-Versus-Leukemia
Choi J, Ritchey J, Prior JL, Holt M, Shannon WD, Deych E, Piwnica-Worms DR, DiPersio JF
Blood 2010 Jul 8;116(1):129-39
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AFF-1, a FOS-1-Regulated Fusogen, Mediates Fusion of the Anchor Cell in C. Elegans
Sapir A*, Choi J*, Leikina E, Avinoam O, Valansi C, Chernomordik LV, Newman AP, Podbilewicz B (* equal contribution)
Dev Cell 2007 May;12(5):683-98
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N-Ethylmaleimide Sensitive Factor Is Required for Fusion of the C. Elegans Uterine Anchor Cell
Choi J, Richards KL, Cinar HN, Newman AP
Dev Biol 2006 Sep 1;297(1):87-102
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A Two-Promoter System of Gene Expression in C. Elegans
Choi J, Newman AP
Dev Biol 2006 Aug 15;296(2):537-44
Peer-reviewed Book Chapters