Jaebok Choi, PhD
Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology
Research Interests
- Allogeneic hematopoietic stem cell transplantation
- GvHD
- IFNγR
- IL6R
- JAK-STAT signaling
Contact
- 314-362-9349 (office)
- 314-273-0153 (lab)
- 314-362-1953 (fax)
- jchoi25@wustl.edu
- Division of Oncology
Campus Box 8007
Washington University
660 South Euclid Avenue
St. Louis, MO 63110 - Room 731 Southwest Tower (office)
- Room 724 Southwest Tower (lab)
Research
The goal of my research is to optimize allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the treatment of hematopoietic malignancies. The clinical goal in allo-HSCT is to prevent graft-versus-host disease (GvHD), a life-threatening complication, from a beneficial graft-versus-leukemia effect (GvL). We have recently found that interferon gamma receptor (IFNGR) and interleukin-6 receptor (IL6R) are the optimal therapeutic targets to completely prevent GvHD while maintaining GvL. Thus, we are interested in defining the roles of IFNGR and IL6R signaling and their downstream JAK-STAT signaling in GvHD and GvL using mouse models of allo-HSCT. These include the modulatory roles of these signaling in T cell immunity and GvHD-damaged tissue repair. My research also focuses on developing novel therapeutic strategies for GvHD by targeting IFNGR, IL6R, and/or JAK-STAT signaling.
