Oncology Division

Obi L. Griffith, PhD

Associate Professor
Department of Medicine
Oncology Division
Stem Cell Biology
Department of Genetics
McDonnell Genome Institute

Research Interests

  • Cancer informatics
  • Clinical statistics
  • Breast cancer



1996-2002 BSc in Biology (Honours) and Biochemistry, University of Winnipeg, Winnipeg, MB, Canada
2003-2004 Molecular Biology Graduate Exchange, Simon Fraser University, Burnaby, BC, Canada
2003-2008 PhD in Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Academic Positions & Employment
2002-2003 Computational Biologist/Sequence Finisher (Steven Jones; Marco Marra), BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada
2008-2010 Post-Doctoral Fellow, Medical Genetics (Steven Jones), BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada
2010-2012 Post-Doctoral Fellow, Cancer & DNA Damage (Joe Gray; Paul Spellman), Lawrence Berkeley National Laboratory, Berkeley, CA
2011-2012 Visiting Scientist, Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR
2012-2014 Research Assistant Professor, Department of Medicine, Washington University, St. Louis, MO
2012-2014 Genome Fellow, The Genome Institute, Washington University, St. Louis, MO
2014-2019 Assistant Professor, Department of Medicine, Washington University, St. Louis, MO
2014-present Assistant Director, The Genome Institute, Washington University, St. Louis, MO
2019-present Associate Professor, Departments of Medicine and Genetics, Washington University, St. Louis, MO
University & Hospital Appointments & Committees
2014-present Member, Division of Biology and Biomedical Sciences
2014-present Member, Siteman Cancer Center
2016-present Faculty, Clinical Informatics Fellowship Program
2016-present Faculty, Molecular Oncology Training Program
2016-present Mentor, Initiative for Maximizing Student Development Program
2017-present Member, Master of Science in Clinical Investigation Curriculum Committee
2018-present Emergency Preparedness Coordinator, McDonnell Genome Institute
External Committees
2006 Program Committee Member, The RegCreative Conference, Ghent, Belgium
2004-2007 Member, Let's Talk Science Partnership Program, University of British Columbia
2008 Sponsorship and Registration Coordinator, Brain Tumor Foundation of Canada
2008-2010 Founding Member, Open Regulatory Annotation Consortium
2010-2011 Program Committee Member, NIH ICBP Junior Investigator Meeting
2010-2011 Program Committee Member, GTC Next Gen Sequencing Conference
2012-present Editor, Biostar Consulting LLC
2013-2014 Member, Illumina Sequencing Experts Panel
2013-2016 Member, Transcription Factor Target Gene Consortium
2013-2016 Member, Network of Biothings
2014-present Member, Canadian Bioinformatics Workshops Planning Committee
2015-present Member, ACS Institutional Research Grant Review Committee
2016 Program Co-Chair, Clinical Interpretation Knowledgebase Hackathon and Curation Jamboree, Amsterdam, Netherlands
2016-2017 Member, AACR Annual Meeting Education Committee
2016-present Founder/Co-Chair, Variant Interpretation for Cancer Consortium (VICC), GA4GH
2017 Session Chair, Resources Section, NCI-ITCR Annual Meeting
2017-2018 Co-Chair, AACR Annual Meeting Program Committee
2017-2018 Co-Chair, AACR Annual Meeting Education Committee
2017-present Board of Directors Member, Cancer Genomics Consortium
2017-present Steering Committee Member, Global Alliance for Genomic Health
2018 ITCR 2018 Annual Meeting Steering Committee
2018 Cancer Genomics Consortium Annual Meeting Organizing Committee
2018-present Communication Committee Member, Cancer Genomics Consortium
2018-present Genomics Resource Development Committee, Cancer Genomics Consortium
2018-present Member, ClinGen Cancer Somatic Work Group
2018-present Member, ClinGen VHL Expert Panel
2018-present Education Advisory Board Member, bioinformatics.ca
2019-2020 Co-Chair, AACR Annual Meeting Program Committee
2019-2020 Co-Chair, AACR Annual Meeting Education Committee
Honors & Awards
2003-2005 NSERC PGS-A Award
2003-2005 MSFHR Junior Trainee Award
2003 UBC Graduate Entrance Scholarship
2003-2006 UBC PhD Tuition Fee Award (4 years)
2004 Albert B. and Mary Steiner Summer Research Award
2004 CIHR National Poster Competition Award (Silver)
2004 John Bosdet Memorial Fund Travel Scholarship
2005-2008 CIHR Canada Graduate Scholarship Doctoral Award
2006 MSFHR Senior Trainee Award
2007 Lloyd Skarsgard Research Excellence Prize
2010-2012 CIHR Fellowship
2015 University of Winnipeg Annual Alumnus Speaker Award
2015 National Academy of Sciences Kavli Fellow
Editorial Boards
Cell Reports
Professional Societies & Organizations
2010-present Active Member, American Association for Cancer Research (AACR)
2014-present Professional Member, International Society for Computational Biology (ISCB)
2016-present Member, American Society of Human Genetics (ASHG)
2016-present Member, Cancer Genomics Consortium (CGC)
Resources Created
2006-present ORegAnno – Open Regulatory Annotation (www.oreganno.org)
2011-present Alexa-Seq – Alternative Expression Analysis of RNA-seq (alexaplatform.org)
2012-present Bioinformatics Tutorials (www.biostars.org/u/3737/)
2012-present Informatics for RNA-seq Analysis online course (www.rnabio.org)
2013-present DGIdb – Drug Gene Interaction database (www.dgidb.org)
2013-present GMS – Genome Modeling System (www.github.com/genome/gms/wiki)
2014-present DoCM – Database of curated mutations (www.docm.info)
2014-present CIViC – Clinical Interpretation of Variants in Cancer (www.civicdb.org)
2015-present GenVisR – Genomic Visualizations in R (https://github.com/griffithlab/GenVisR)
2016-present pVACtools – Personalized Cancer Vaccines (www.pvactools.org)
2017-present Genomic Visualizations and Interpretations online course (www.genviz.org)
2018-present Precision Medicine Bioinformatics online course (pmbio.org)