Faculty
Griffith_M.jpg

Malachi Griffith, PhD

Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology
Department of Genetics
McDonnell Genome Institute

Research Interests

  • Cancer informatics
  • Bioinformatics
  • Genomics
  • Precision medicine
  • Immunogenomics

Contact

  • 314-286-1274 (phone)
  • 314-286-1810 (fax)
  • Room 5139, 4444 Forest Park Avenue (lab)
  • McDonnell Genome Institute
    Washington University
    Campus Box 8501
    4444 Forest Park Avenue
    St. Louis, MO 63108
  • Lab Website

Biosketch

Education
1996-2002 BSc in Biology (Honors) and Biochemistry, University of Winnipeg, Winnipeg, MB, Canada
2004-2005 Molecular Biology Graduate Exchange, Simon Fraser University, Burnaby, BC, Canada
2004-2010 PhD in Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Academic Positions & Employment
2010-2011 Post-Doctoral Fellow, Michael Smith Genome Sciences Center, Vancouver, BC, Canada
2011-2014 Research Instructor, Genetics, Washington University School of Medicine, St. Louis, MO
2011-2014 Genome Fellow, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
2011-present Instructor, Cold Spring Harbor Laboratory, NY
2011-present Instructor, Canadian Bioinformatics Workshops, Toronto, ON, Canada
2014-present Assistant Professor, Department of Genetics, Washington University School of Medicine, St. Louis, MO
2014-present Assistant Director, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO
2017-present Assistant Professor, Department of Medicine, Washington University School of Medicine, St. Louis, MO
University & Hospital Appointments & Committees
2015-present Member, Siteman Cancer Center
2017-present Member, Division of Biology and Biomedical Sciences
External Committees
2007 Conference Chair, Discovery2Diagnostics Conference, 'Emerging Microarrays and Technologies', Philadelphia, PA
2012-2014 Member, Illumina Sequencing Experts Panel
2012-present Editor, Biostar Consulting LLC
2013-present Canadian Bioinformatics Workshops Organizing Committee
2015 Conference Chair, The Clinical Genome Conference, 'Understanding Wellness' Session, San Francisco, CA
2015-present Annual Meeting Education Committee of the American Association for Cancer Research (AACR)
2016 Program Co-Chair, Clinical Interpretation Knowledgebase Hackathon and Curation Jamboree, Amsterdam, Netherlands
2016 Methods Workshop Chair, American Association of Cancer Research Annual Meeting, Interpretation of Variants in Cancer
2016-present Co-Chair, Variant Interpretation for Cancer Consortium (VICC), GA4GH
2017 Member, Planning the 5-year Vision of Global Alliance for Genomics Health (GA4GH)
2018 Methods Workshop Chair, American Association of Cancer Research Annual Meeting, Computational Methods and Resources for Immunogenomics and Immune Therapy
2018 Discussion Leader of the Data-Driven Approaches for Precision Medicine Session, Human Genetic Variation and Disease, Gordon Research Conference
2018-present Steering Committee, GA4GH
Awards
1996 University of Winnipeg, Special Entrance Scholarship
1999 University of Winnipeg, Academic Proficiency Scholarship
1999-2002 University of Winnipeg, Student of Highest Distinction
2001 Dr. Edgar Van Nuys Allen Scholarship
2004 University of British Columbia, PhD Tuition Award
2004 Michael Smith Foundation for Health Research, Junior Trainee Award
2004 Natural Sciences and Engineering Research Council, Masters Award
2004 University of British Columbia, Graduate Entrance Scholarship
2005 Natural Sciences and Engineering Research Council, Doctoral Award
2006 Michael Smith Foundation for Health Research, Senior Trainee Award
2008 NCIC and Terry Fox Foundation, Research Studentship
2009 John Bosdet Memorial Fund, Graduate Student Travel Scholarship
2009 Lloyd Skarsgard Research Excellence Prize
Other Honors
2012 Profiled in Genome Technology Magazine’s Seventh Annual Young Investigators issue as an ‘up and coming investigator’
2013 Profiled in Wired Magazine’s Second Annual ‘Smart List’ as an emerging talent
Professional Societies & Organizations
2014-present Active Member, American Society of Clinical Oncology (ASCO)
2014-present Professional Member, International Society for Computational Biology (ISCB)
2015-present Active Member, American Association for Cancer Research (AACR)
2016-present Active Member, American Society of Human Genetics (ASHG)
2016-present Global Alliance for Genomics Health (GA4GH)
2018-present Affiliate Scientist Member, American College of Medical Genetics and Genomics
Bioinformatics Resources Created
2006-present ORegAnno - Open Regulatory Annotation (www.oreganno.org)
2011-present Alternative Expression Analysis of RNA-seq (alexaplatform.org/)
2012-present RNA-seq analysis workshops (www.bioinformatics.ca/workshops/)
2012-present Bioinformatics tutorials (www.biostars.org/u/3737/)
2013-present GMS - Genome Modeling System (www.github.com/genome/gms/wiki)
2013-present DGIdb - Drug Gene Interaction database (www.dgidb.org)
2013-present RNA-Bio - RNA-seq analysis on the cloud (www.rnabio.org)
2014-present DoCM - Database of Curated Mutations (www.docm.info)
2015-present CIViC - Clinical interpretation of variants in cancer (www.civicdb.org)
2016-present GenVisR - Genome visualizations in R (github.com/griffithlab/GenVisR)
2016-present pVAC-Seq - A cancer immunotherapy pipeline for the identification of personalized Variant Antigens by Cancer Sequencing (github.com/griffithlab/pVAC-Seq)
2016-present RegTools - Integrated analysis of DNA-seq and RNA-seq data to help identify mutations that have a regulatory effect (regtools.org/)
2017-present Genome data visualization and interpretation workshop (genviz.org/)
2017-present pVAC-tools – Bioinformatics tools for immunogenomics (www.pvactools.org)
2017-present Variant Interpretation for Cancer Consortium (cancervariants.org/)
2018-present Precision Medicine Bioinformatics workshop (pmbio.org/)