Oncology Division

James J. Hsieh, MD, PhD

Department of Medicine
Oncology Division
Molecular Oncology
Medical Oncology

Clinical Interests

  • Kidney cancer

Research Interests

  • Kidney cancer metabolomics
  • Genomics, Epigenetics
  • Therapeutics, Precision Medicine
  • Translational kidney cancer research
  • Mouse tumor models, Mouse development
  • Drug development
  • Taspase1, Notch, MLL, Stem cells


  • 314-273-1688 (lab)
  • 314-454-8681 (clinic)
  • 314-362-7086 (fax)
  • 554 McDonnell Medical Sciences Building (office/lab)
  • Division of Oncology
    Campus Box 8069
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Books, Book Chapters & Reviews

  • BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis
    Jeng PS, Inoue-Yamauchi A, Hsieh JJ, Cheng EH
    Current Opinion in Physiology 2018;3:71-81
  • Genomic Classifications of Renal Cell Carcinoma: A Critical Step Towards the Future Application of Personalized Kidney Cancer Care With Pan-Omics Precision
    Hsieh JJ, Le V, Cao D, Cheng EH, Creighton CJ
    J Pathol 2018 Apr;244(5):525-537
  • Molecular Classification of Renal Cell Carcinoma and Its Implication in Future Clinical Practice
    Casuscelli J, Yann-Alexandre V, Fridman WH, Hsieh JJ
    Kidney Cancer 2017;1(1):3-13
  • Are We Ready for Adjuvant Sunitinib in High-Risk Renal Cell Carcinoma?
    Casuscelli J, Hsieh JJ
    Eur Urol 2018 Jan;73(1):69-70
  • SWI/SNF Tumor Suppressor Gene PBRM1/BAF180 in Human Clear Cell Kidney Cancer
    Nargund AM, Osmanbeyoglu HU, Cheng EH, Hsieh JJ
    Mol Cell Oncol 2017 Jun 19;4(4):e1342747
  • Renal Cell Carcinoma
    Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
    Nat Rev Dis Primers 2017 Mar 9;3:17009
  • Molecular Markers of Prognostic Significance and Treatment Response
    Carlo M, Hsieh JJ
    In: Precision Molecular Pathology of Renal Cell Carcinoma, 2017
  • The Evolution of Metastatic Kidney Cancer Treatment
    Casuscelli J, Hsieh JJ
    BJUI Knowledge 2017
  • Overcome Tumor Heterogeneity-Imposed Therapeutic Barriers Through Convergent Genomic Biomarker Discovery: A Braided Cancer River Model of Kidney Cancer
    Hsieh JJ, Manley BJ, Khan N, Gao J, Carlo MI, Cheng EH
    Semin Cell Dev Biol 2017 Apr;64:98-106
  • The Panoramic View of Clear Cell Renal Cell Carcinoma Metabolism: Values of Integrated Global Cancer Metabolomics
    Hsieh JJ, Cheng EH
    Transl Androl Urol 2016 Dec;5(6):984-986
  • A Braided Cancer River Connects Tumor Heterogeneity and Precision Medicine
    Hsieh JJ, Cheng EH
    Clin Transl Med 2016 Dec;5(1):42
  • Sarcomatoid Renal Cell Carcinoma: Genomic Insights From Sequencing of Matched Sarcomatous and Carcinomatous Components
    Manley BJ, Hsieh JJ
    Transl Cancer Res 2016 Aug;5(Suppl 2):S160-S165
  • Therapeutic Guide for MTOuRing Through the Braided Kidney Cancer Genomic River
    Voss MH, Hsieh JJ
    Clin Cancer Res 2016 May 15;22(10):2320-2
  • Bevacizumab Monotherapy as Salvage Therapy for Advanced Clear Cell Renal Cell Carcinoma Pretreated With Targeted Drugs
    Lee CH, Hotker AM, Voss MH, Feldman DR, Woo KM, Patil S, Coskey DT, Akin O, Hsieh JJ, Motzer RJ
    Clin Genitourin Cancer 2016 Feb;14(1):56-62
  • PBRM1: A Critical Subunit of the SWI/SNF Chromatin Redmodeling Complex
    Lee CH, Pham CG, Hsieh JJ
    In: Renal Cell Carcinoma: Molecular Targets and Clinical Applications, 3rd Edition, 2015
  • A River Model to Map Convergent Cancer Evolution and Guide Therapy in RCC
    Wei EY, Hsieh JJ
    Nat Rev Urol 2015 Dec;12(12):706-12
  • Taspase 1: A Protease With Many Biological Surprises
    Niizuma H, Cheng EH, Hsieh JJ
    Mol Cell Oncol 2015 Jan 23;2(4):e999513
  • A Systematic Review of Predictive and Prognostic Biomarkers for VEGF-Targeted Therapy in Renal Cell Carcinoma
    Funakoshi T, Lee CH, Hsieh JJ
    Cancer Treat Rev 2014 May;40(4):533-47
  • Treatment Outcome With mTOR Inhibitors for Metastatic Renal Cell Carcinoma With Nonclear and Sarcomatoid Histologies
    Voss MH, Bastos DA, Karlo CA, Ajeti A, Hakimi AA, Feldman DR, Hsieh JJ, Molina AM, Patil S, Motzer RJ
    Ann Oncol 2014 Mar;25(3):663-8
  • A Clear Picture of Renal Cell Carcinoma
    Hakimi AA, Pham CG, Hsieh JJ
    Nat Genet 2013 Aug;45(8):849-50
  • Novel Approaches Targeting the Vascular Endothelial Growth Factor Axis in Renal Cell Carcinoma
    Voss MH, Hsieh JJ, Motzer RJ
    Cancer J 2013 Jul-Aug;19(4):299-306
  • Taspase1
    Cunha L, Tong L, Hsieh JJ
    In: Handbook of Proteolytic Enzymes (Rawlings ND, Salvesen G, Eds.), 2013
  • "Targeting Taspase1 for Cancer Therapy"-Response
    Chen DY, Takeda S, Oyama T, Hsieh JJ
    Cancer Res 2012 Jun 1;72(11):2913
  • MLL Fusions: Pathways to Leukemia
    Liu H, Cheng EH, Hsieh JJ
    Cancer Biol Ther 2009 Jul;8(13):1204-11
  • MLL5 Governs Hematopoiesis: A Step Closer
    Liu H, Westergard TD, Hsieh JJ
    Blood 2009 Feb 12;113(7):1395-6
  • Deadly Splicing: Bax Becomes Almighty
    Kim H, Hsieh JJ, Cheng EH
    Mol Cell 2009 Jan 30;33(2):145-6
  • Biphasic MLL Takes Helm at Cell Cycle Control: Implications in Human Mixed Lineage Leukemia
    Liu H, Takeda S, Cheng EH, Hsieh JJ
    Cell Cycle 2008 Feb 15;7(4):428-35
  • Genomic Approaches to the Pathogenesis and Treatment of Acute Lymphoblastic Leukemias
    Armstrong SA, Hsieh JJ, Korsmeyer SJ
    Curr Opin Hematol 2002 Jul;9(4):339-44
  • Identification of Transactivation, Repression, and Protein-Protein Interaction Domains Using GAL4-Fusion Proteins
    Hsieh JJ, Hayward SD
    Methods Mol Biol 2001;174:259-69