Faculty
Kilannin Krysiak.jpg

Kilannin Krysiak, PhD

Instructor
Department of Medicine
Oncology Division
Stem Cell Biology

Research Interests

  • Precision medicine
  • Cancer genomics
  • Lymphoma

Contact

  • 314-747-9284 (tel)
  • McDonnell Genome Institute
Washington University School of Medicine
    Campus Box 8501
    4444 Forest Park Avenue
    St. Louis, MO 63108

Peer-reviewed publications

  • Single-Agent Ibrutinib in Relapsed or Refractory Follicular Lymphoma: A Phase 2 Consortium Trial
    Bartlett NL, Costello BA, LaPlant BR, Ansell SM, Kuruvilla JG, Reeder CB, Thye LS, Anderson DM, Krysiak K, Ramirez C, Qi J, Siegel BA, Griffith M, Griffith OL, Gomez F, Fehniger TA
    Blood 2017 Oct 26; [Epub ahead of print]
  • CIViC Is a Community Knowledgebase for Expert Crowdsourcing the Clinical Interpretation of Variants in Cancer
    Griffith M, Spies NC, Krysiak K, McMichael JF, Coffman AC, Danos AM, Ainscough BJ, Ramirez CA, Rieke DT, Kujan L, Barnell EK, Wagner AH, Skidmore ZL, Wollam A, Liu CJ, Jones MR, Bilski RL, Lesurf R, Feng YY, Shah NM, Bonakdar M, Trani L, Matlock M, Ramu A, Campbell KM, Spies GC, Graubert AP, Gangavarapu K, Eldred JM, Larson DE, Walker JR, Good BM, Wu C, Su AI, Dienstmann R, Margolin AA, Tamborero D, Lopez-Bigas N, Jones SJ, Bose R, Spencer DH, Wartman LD, Wilson RK, Mardis ER, Griffith OL
    Nat Genet 2017 Jan 31;49(2):170-174
  • A Phase II Trial of Neoadjuvant MK2206, an AKT Inhibitor, With Anastrozole in Clinical Stage 2 or 3 PIK3CA Mutant ER Positive and HER2 Negative Breast Cancer
    Ma CX, Suman V, Goetz MP, Northfelt DW, Burkard ME, Ademuyiwa F, Naughton MJ, Margenthaler J, Aft R, Gray RJ, Tevaarwerk AJ, Wilke LG, Haddad TC, Moynihan T, Loprenzi C, Hieken T, Barnell EK, Skidmore ZL, Feng YY, Krysiak K, Hoog J, Guo Z, Nehring L, Wisinski KB, Mardis ER, Hagemann IS, Vij K, Sanati S, Al-Kateb H, Griffith OL, Griffith M, Doyle A, Erlichman C, Ellis MJ
    Clin Cancer Res 2017 Sep 5; [Epub ahead of print]
  • Melorheostosis: Exome Sequencing of an Associated Dermatosis Implicates Postzygotic Mosaicism of Mutated KRAS
    Whyte MP, Griffith M, Trani L, Mumm S, Gottesman GS, McAlister WH, Krysiak K, Lesurf R, Skidmore ZL, Campbell KM, Rosman IS, Bayliss S, Bijanki VN, Nenninger A, Van Tine BA, Griffith OL, Mardis ER
    Bone 2017 Aug;101:145-155
  • Knockdown of HSPA9 Induces TP53-Dependent Apoptosis in Human Hematopoietic Progenitor Cells
    Liu T, Krysiak K, Shirai CL, Kim S, Shao J, Ndonwi M, Walter MJ
    PLoS One 2017 Feb 8;12(2):e0170470
  • Recurrent Somatic Mutations Affecting B-Cell Receptor Signaling Pathway Genes in Follicular Lymphoma
    Krysiak K, Gomez F, White BS, Matlock M, Miller CA, Trani L, Fronick CC, Fulton RS, Kreisel F, Cashen AF, Carson KR, Berrien-Elliott MM, Bartlett NL, Griffith M, Griffith OL, Fehniger TA
    Blood 2017 Jan 26;129(4):473-483
  • Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas
    Griffith OL, Chan SR, Griffith M, Krysiak K, Skidmore ZL, Hundal J, Allen JA, Arthur CD, Runci D, Bugatti M, Miceli AP, Schmidt H, Trani L, Kanchi KL, Miller CA, Larson DE, Fulton RS, Vermi W, Wilson RK, Schreiber RD, Mardis ER
    Cell Rep 2016 Sep 27;17(1):249-60
  • Comprehensive Genomic Analysis Reveals FLT3 Activation and a Therapeutic Strategy for a Patient With Relapsed Adult B-Lymphoblastic Leukemia
    Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
    Exp Hematol 2016 Jul;44(7):603-13
  • A Genomic Case Study of Mixed Fibrolamellar Hepatocellular Carcinoma
    Griffith OL, Griffith M, Krysiak K, Magrini V, Ramu A, Skidmore ZL, Kunisaki J, Austin R, McGrath S, Zhang J, Demeter R, Graves T, Eldred JM, Walker J, Larson DE, Maher CA, Lin Y, Chapman W, Mahadevan A, Miksad R, Nasser I, Hanto DW, Mardis ER
    Ann Oncol 2016 Jun;27(6):1148-54
  • A Genomic Analysis of Philadelphia Chromosome-Negative AML Arising in Patients With CML
    Krysiak K, Christopher MJ, Skidmore ZL, Demeter RT, Magrini V, Kunisaki J, O'Laughlin M, Duncavage EJ, Miller CA, Ozenberger BA, Griffith M, Wartman LD, Griffith OL
    Blood Cancer J 2016 Apr 8;6:e413
  • DGIdb 2.0: Mining Clinically Relevant Drug-Gene Interactions
    Wagner AH, Coffman AC, Ainscough BJ, Spies NC, Skidmore ZL, Campbell KM, Krysiak K, Pan D, McMichael JF, Eldred JM, Walker JR, Wilson RK, Mardis ER, Griffith M, Griffith OL
    Nucleic Acids Res 2016 Jan 4;44(D1):D1036-44
  • Optimizing Cancer Genome Sequencing and Analysis
    Griffith M, Miller CA, Griffith OL, Krysiak K, Skidmore ZL, Ramu A, Walker JR, Dang HX, Trani L, Larson DE, Demeter RT, Wendl MC, McMichael JF, Austin RE, Magrini V, McGrath SD, Ly A, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Maher CA, Ding L, Klco JM, Mardis ER, Ley TJ, Wilson RK
    Cell Syst 2015 Sep 23;1(3):210-223
  • Reduced Levels of Hspa9 Attenuate Stat5 Activation in Mouse B Cells
    Krysiak K, Tibbitts JF, Shao J, Liu T, Ndonwi M, Walter MJ
    Exp Hematol 2015 Apr;43(4):319-30e10
  • Recurrent Mutations in the U2AF1 Splicing Factor in Myelodysplastic Syndromes
    Graubert TA, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris CC, Koboldt DC, Larson DE, McLellan MD, Dooling DJ, Abbott RM, Fulton RS, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Grillot M, Baty J, Heath S, Frater JL, Nasim T, Link DC, Tomasson MH, Westervelt P, DiPersio JF, Mardis ER, Ley TJ, Wilson RK, Walter MJ
    Nat Genet 2011 Dec 11;44(1):53-7
  • Knockdown of Hspa9, a del(5q31.2) Gene, Results in a Decrease in Hematopoietic Progenitors in Mice
    Chen TH, Kambal A, Krysiak K, Walshauser MA, Raju G, Tibbitts JF, Walter MJ
    Blood 2011 Feb 3;117(5):1530-9
  • Lipophilic Pyridinium Bisphosphonates: Potent Gammadelta T Cell Stimulators
    Zhang Y, Cao R, Yin F, Lin FY, Wang H, Krysiak K, No JH, Mukkamala D, Houlihan K, Li J, Morita CT, Oldfield E
    Angew Chem Int Ed Engl 2010 Feb 1;49(6):1136-8
  • Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-Ray and NMR Investigation
    Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E
    J Am Chem Soc 2009 Apr 15;131(14):5153-62
  • Bisphosphonate Inhibitors of ATP-Mediated HIV-1 Reverse Transcriptase Catalyzed Excision of Chain-Terminating 3'-Azido, 3'-Deoxythymidine: A QSAR Investigation
    Song Y, Chan JM, Tovian Z, Secrest A, Nagy E, Krysiak K, Bergan K, Parniak MA, Oldfield E
    Bioorg Med Chem 2008 Oct 1;16(19):8959-67
  • Activity of Sulfonium Bisphosphonates on Tumor Cell Lines
    Zhang Y, Hudock MP, Krysiak K, Cao R, Bergan K, Yin F, Leon A, Oldfield E
    J Med Chem 2007 Nov 29;50(24):6067-79