Oncology Division
Alphabetical list (active faculty):   
Timothy J. Ley

Timothy J. Ley, MD

Lewis T. and Rosalind B. Apple Chair in Oncology


Department of Medicine

Oncology Division

Stem Cell Biology

Department of Genetics

Research Interests

  • Mouse models of acute myeloid leukemias (AML)
  • AML genomics and epigenetics


  • 314-362-8831 (office)
  • 314-362-8832 (lab)
  • 314-362-9333 (fax)
  • Division of Oncology
    Mail Stop 8007-0057-06
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • 629 Southwest Tower (office)
  • 629 Southwest Tower (lab)

Peer-reviewed Manuscripts

  • IL-1beta Expression in Bone Marrow Dendritic Cells Is Induced by TLR2 Agonists and Regulates HSC Function
    Li S, Yao JC, Oetjen KA, Krambs JR, Xia J, Zhang J, Schmidt AP, Helton NM, Fulton RS, Heath SE, Turnbull IR, Mbalaviele G, Ley TJ, Walter MJ, Link DC
    Blood 2022 Oct 6;140(14):1607-1620
  • Description of a Novel Subtype of Acute Myeloid Leukemia Defined by Recurrent CBFB Insertions
    Ryland G, Umeda M, Holmfeldt L, Lehmann S, Herlin MK, Ma JJ, Khanlari M, Rubnitz JE, Ries RE, Kosasih HJ, Ekert PG, Goh HN, Tiong IS, Grimmond SM, Haferlach C, Day RB, Ley TJ, Meshinchi S, Ma X, Blombery P, Klco JM
    Blood 2022 Sep 30:blood2022017874; [ahead of print]
  • Proteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia
    Kramer MH, Zhang Q, Sprung R, Day RB, Erdmann-Gilmore P, Li Y, Xu Z, Helton NM, George DR, Mi Y, Westervelt P, Payton JE, Ramakrishnan SM, Miller CA, Link DC, DiPersio JF, Walter MJ, Townsend RR, Ley TJ
    Blood 2022 Sep 29;140(13):1533-1548
  • Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
    Menssen AJ, Khanna A, Miller CA, Nonavinkere Srivatsan S, Chang GS, Shao J, Robinson J, O'Laughlin M, Fronick CC, Fulton RS, Brendel K, Heath SE, Saba R, Welch JS, Spencer DH, Payton JE, Westervelt P, DiPersio JF, Link DC, Schuelke MJ, Jacoby MA, Duncavage EJ, Ley TJ, Walter MJ
    Blood Cancer Discov 2022 Jul 6;3(4):330-345
  • Decitabine Salvage for TP53-Mutated, Relapsed/Refractory Acute Myeloid Leukemia After Cytotoxic Induction Therapy
    Ferraro F, Gruszczynska A, Ruzinova MB, Miller CA, Percival ME, Uy GL, Pusic I, Jacoby MA, Christopher MJ, Kim MY, Westervelt P, Cashen AF, Schroeder MA, DiPersio JF, Abboud CN, Wartman LD, Gao F, Link DC, Ley TJ, Welch JS
    Haematologica 2022 Jul 1;107(7):1709-1713
  • Physician-Scientists in the United States at 2020: Trends and Concerns
    Garrison HH, Ley TJ
    FASEB J 2022 May;36(5):e22253
  • Recurrent Transcriptional Responses in AML and MDS Patients Treated With Decitabine
    Upadhyay P, Beales J, Shah NM, Gruszczynska A, Miller CA, Petti AA, Ramakrishnan SM, Link DC, Ley TJ, Welch JS
    Exp Hematol 2022 Jul;111:50-65
  • Somatic Dnmt3a Inactivation Leads to Slow, Canonical DNA Methylation Loss in Murine Hematopoietic Cells
    Smith AM, Verdoni AM, Abel HJ, Chen DY, Ketkar S, Leight ER, Miller CA, Ley TJ
    iScience 2022 Mar 3;25(4):104004
  • DNMT3A Overgrowth Syndrome Is Associated With the Development of Hematopoietic Malignancies in Children and Young Adults
    Ferris MA, Smith AM, Heath SE, Duncavage EJ, Oberley M, Freyer D, Wynn R, Douzgou S, Maris JM, Reilly AF, Wu MD, Choo F, Fiets RB, Koene S, Spencer DH, Miller CA, Shinawi M, Ley TJ
    Blood 2022 Jan 20;139(3):461-464
  • Failure to Detect Mutations in U2AF1 Due to Changes in the GRCh38 Reference Sequence
    Miller CA, Walker JR, Jensen TL, Hooper WF, Fulton RS, Painter JS, Sekeres MA, Ley TJ, Spencer DH, Goll JB, Walter MJ
    J Mol Diagn 2022 Mar;24(3):219-223
  • Focal Disruption of DNA Methylation Dynamics at Enhancers in IDH-Mutant AML Cells
    Wilson ER, Helton NM, Heath SE, Fulton RS, Payton JE, Welch JS, Walter MJ, Westervelt P, DiPersio JF, Link DC, Miller CA, Ley TJ, Spencer DH
    Leukemia 2022 Apr;36(4):935-945
  • Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
    Petti AA, Khan SM, Xu Z, Helton N, Fronick CC, Fulton R, Ramakrishnan SM, Nonavinkere Srivatsan S, Heath SE, Westervelt P, Payton JE, Walter MJ, Link DC, DiPersio J, Miller C, Ley TJ
    Blood Cancer Discov 2022 Jan;3(1):32-49
  • Tumor Suppressor Function of WT1 in Acute Promyelocytic Leukemia
    Christopher MJ, Katerndahl CDS, LeBlanc HR, Elmendorf TT, Basu V, Gang M, Menssen AJ, Spencer DH, Duncavage EJ, Ketkar S, Wartman LD, Ramakrishnan SM, Miller CA, Ley TJ
    Haematologica 2022 Jan 1;107(1):342-346
  • Immunosuppression and Outcomes in Adult Patients With De Novo Acute Myeloid Leukemia With Normal Karyotypes
    Ferraro F, Miller CA, Christensen KA, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Kohlschmidt J, Eisfeld AK, Bloomfield CD, Ramakrishnan SM, Day RB, Wartman LD, Uy GL, Welch JS, Christopher MJ, Heath SE, Baty JD, Schuelke MJ, Payton JE, Spencer DH, Rettig MP, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ
    Proc Natl Acad Sci U S A 2021 Dec 7;118(49):e2116427118
  • Tumor Suppressor Function of Gata2 in Acute Promyelocytic Leukemia
    Katerndahl CDS, Rogers ORS, Day RB, Cai MA, Rooney TP, Helton NM, Hoock M, Ramakrishnan SM, Nonavinkere Srivatsan S, Wartman LD, Miller CA, Ley TJ
    Blood 2021 Sep 30;138(13):1148-1161
  • Functional and Epigenetic Phenotypes of Humans and Mice With DNMT3A Overgrowth Syndrome
    Smith AM, LaValle TA, Shinawi M, Ramakrishnan SM, Abel HJ, Hill CA, Kirkland NM, Rettig MP, Helton NM, Heath SE, Ferraro F, Chen DY, Adak S, Semenkovich CF, Christian DL, Martin JR, Gabel HW, Miller CA, Ley TJ
    Nat Commun 2021 Jul 27;12(1):4549
  • Co-Evolution of Tumor and Immune Cells During Progression of Multiple Myeloma
    Liu R, Gao Q, Foltz SM, Fowles JS, Yao L, Wang JT, Cao S, Sun H, Wendl MC, Sethuraman S, Weerasinghe A, Rettig MP, Storrs EP, Yoon CJ, Wyczalkowski MA, McMichael JF, Kohnen DR, King J, Goldsmith SR, O'Neal J, Fulton RS, Fronick CC, Ley TJ, Jayasinghe RG, Fiala MA, Oh ST, DiPersio JF, Vij R, Ding L
    Nat Commun 2021 May 7;12(1):2559
  • Dnmt3a Deficiency in the Skin Causes Focal, Canonical DNA Hypomethylation and a Cellular Proliferation Phenotype
    Chen DY, Ferguson IM, Braun KA, Sutton LA, Helton NM, Ramakrishnan SM, Smith AM, Miller CA, Ley TJ
    Proc Natl Acad Sci U S A 2021 Apr 20;118(16):e2022760118
  • Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers
    Duncavage EJ, Schroeder MC, O'Laughlin M, Wilson R, MacMillan S, Bohannon A, Kruchowski S, Garza J, Du F, Hughes AEO, Robinson J, Hughes E, Heath SE, Baty JD, Neidich J, Christopher MJ, Jacoby MA, Uy GL, Fulton RS, Miller CA, Payton JE, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Spencer DH
    N Engl J Med 2021 Mar 11;384(10):924-935
  • Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia
    Barnell EK, Newcomer KF, Skidmore ZL, Krysiak K, Anderson SR, Wartman LD, Oh ST, Welch JS, Stockerl-Goldstein KE, Vij R, Cashen AF, Pusic I, Westervelt P, Abboud CN, Ghobadi A, Uy GL, Schroeder MA, DiPersio JF, Politi MC, Spencer DH, Duncavage EJ, Ley TJ, Griffith M, Jacoby MA, Griffith OL
    JCO Precis Oncol 2021 Jan 14;5
  • Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease
    Li Y, Miller CA, Shea LK, Jiang X, Guzman MA, Chandler RJ, Ramakrishnan SM, Smith SN, Venditti CP, Vogler CA, Ory DS, Ley TJ, Sands MS
    Mol Ther 2021 Feb 3;29(2):691-701
  • The Clonal Evolution of Metastatic Colorectal Cancer
    Dang HX, Krasnick BA, White BS, Grossman JG, Strand MS, Zhang J, Cabanski CR, Miller CA, Fulton RS, Goedegebuure SP, Fronick CC, Griffith M, Larson DE, Goetz BD, Walker JR, Hawkins WG, Strasberg SM, Linehan DC, Lim KH, Lockhart AC, Mardis ER, Wilson RK, Ley TJ, Maher CA, Fields RC
    Sci Adv 2020 Jun 10;6(24):eaay9691
  • Long Non-Coding RNA RAMS11 Promotes Metastatic Colorectal Cancer Progression
    Silva-Fisher JM, Dang HX, White NM, Strand MS, Krasnick BA, Rozycki EB, Jeffers GGL, Grossman JG, Highkin MK, Tang C, Cabanski CR, Eteleeb A, Mudd J, Goedegebuure SP, Luo J, Mardis ER, Wilson RK, Ley TJ, Lockhart AC, Fields RC, Maher CA
    Nat Commun 2020 May 1;11(1):2156
  • Remethylation of Dnmt3a (-/-) Hematopoietic Cells Is Associated With Partial Correction of Gene Dysregulation and Reduced Myeloid Skewing
    Ketkar S, Verdoni AM, Smith AM, Bangert CV, Leight ER, Chen DY, Brune MK, Helton NM, Hoock M, George DR, Fronick C, Fulton RS, Ramakrishnan SM, Chang GS, Petti AA, Spencer DH, Miller CA, Ley TJ
    Proc Natl Acad Sci U S A 2020 Feb 11;117(6):3123-3134
  • Obesity Is a Risk Factor for Acute Promyelocytic Leukemia: Evidence From Population and Cross-Sectional Studies and Correlation With FLT3 Mutations and Polyunsaturated Fatty Acid Metabolism
    Mazzarella L, Botteri E, Matthews A, Gatti E, Di Salvatore D, Bagnardi V, Breccia M, Montesinos P, Bernal T, Gil C, Ley TJ, Sanz M, Bhaskaran K, Coco FL, Pelicci PG
    Haematologica 2020 Jun;105(6):1559-1566
  • A General Approach for Detecting Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing
    Petti AA, Williams SR, Miller CA, Fiddes IT, Srivatsan SN, Chen DY, Fronick CC, Fulton RS, Church DM, Ley TJ
    Nat Commun 2019 Aug 14;10(1):3660
  • Immune Escape of AML Cells After Transplantation. Reply
    Christopher M, DiPersio JF, Ley TJ
    N Engl J Med 2019 Mar 28;380(13):1290
  • Immune Escape of Relapsed AML Cells After Allogeneic Transplantation
    Christopher MJ, Petti AA, Rettig MP, Miller CA, Chendamarai E, Duncavage EJ, Klco JM, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Wilson RK, Wartman LD, Welch JS, Heath SE, Baty JD, Payton JE, Graubert TA, Link DC, Walter MJ, Westervelt P, Ley TJ, DiPersio JF
    N Engl J Med 2018 Dec 13;379(24):2330-2341
  • Mutation Clearance After Transplantation for Myelodysplastic Syndrome
    Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ
    N Engl J Med 2018 Sep 13;379(11):1028-1041
  • miR142 Loss-Of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis
    Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty J, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy PR, Link DC
    Cancer Res 2018 Jul 1;78(13):3510-3521
  • Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy
    Spencer DH, Ley TJ
    JAMA 2018 Apr 10;319(14):1497-1498
  • DNMT3A(R882)-Associated Hypomethylation Patterns Are Maintained in Primary AML Xenografts, but Not in the DNMT3A(R882C) OCI-AML3 Leukemia Cell Line
    Chen D, Christopher M, Helton NM, Ferguson I, Ley TJ, Spencer DH
    Blood Cancer J 2018 Apr 4;8(4):38
  • Subclones Dominate at MDS Progression Following Allogeneic Hematopoietic Cell Transplant
    Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
    JCI Insight 2018 Mar 8;3(5)
  • Cellular Stressors Contribute to the Expansion of Hematopoietic Clones of Varying Leukemic Potential
    Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC
    Nat Commun 2018 Jan 31;9(1):455
  • Expression Profiling of snoRNAs in Normal Hematopoiesis and AML
    Warner WA, Spencer DH, Trissal M, White BS, Helton N, Ley TJ, Link DC
    Blood Adv 2018 Jan 23;2(2):151-163
  • Haploinsufficiency for DNA Methyltransferase 3A Predisposes Hematopoietic Cells to Myeloid Malignancies
    Cole CB, Russler-Germain DA, Ketkar S, Verdoni AM, Smith AM, Bangert CV, Helton NM, Guo M, Klco JM, O'Laughlin S, Fronick C, Fulton R, Chang GS, Petti AA, Miller CA, Ley TJ
    J Clin Invest 2017 Oct 2;127(10):3657-3674
  • Comprehensive Discovery of Noncoding RNAs in Acute Myeloid Leukemia Cell Transcriptomes
    Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Klco JM, Mardis ER, Ley TJ, Wilson RK, Maher CA
    Exp Hematol 2017 Nov;55:19-33
  • Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy
    Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
    Leukemia 2017 Apr;31(4):872-881
  • Decitabine in TP53-Mutated AML
    Welch JS, Petti AA, Ley TJ
    N Engl J Med 2017 Feb 23;376(8):797-8
  • CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
    Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
    Cell 2017 Feb 23;168(5):801-816
  • Mutational Landscape and Response Are Conserved in Peripheral Blood of AML and MDS Patients During Decitabine Therapy
    Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
    Blood 2017 Mar 9;129(10):1397-1401
  • TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
    Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
    N Engl J Med 2016 Nov 24;375(21):2023-2036
  • Targeted Sequencing Informs the Evaluation of Normal Karyotype Cytopenic Patients for Low-Grade Myelodysplastic Syndrome
    Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
    Leukemia 2016 Dec;30(12):2422-2426
  • Visualizing Tumor Evolution With the Fishplot Package for R
    Miller CA, McMichael J, Dang HX, Maher CA, Ding L, Ley TJ, Mardis ER, Wilson RK
    BMC Genomics 2016 Nov 7;17(1):880
  • Comprehensive Genomic Analysis Reveals FLT3 Activation and a Therapeutic Strategy for a Patient With Relapsed Adult B-Lymphoblastic Leukemia
    Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
    Exp Hematol 2016 Jul;44(7):603-13
  • Rapid Expansion of Preexisting Nonleukemic Hematopoietic Clones Frequently Follows Induction Therapy for De Novo AML
    Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
    Blood 2016 Feb 18;127(7):893-7
  • PML-RARA Requires DNA Methyltransferase 3A to Initiate Acute Promyelocytic Leukemia
    Cole CB, Verdoni AM, Ketkar S, Leight ER, Russler-Germain DA, Lamprecht TL, Demeter RT, Magrini V, Ley TJ
    J Clin Invest 2016 Jan 4;126(1):85-98
  • Patterns and Functional Implications of Rare Germline Variants Across 12 Cancer Types
    Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, DiPersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L
    Nat Commun 2015 Dec 22;6:10086
  • Genomic Analysis of Germ Line and Somatic Variants in Familial Myelodysplasia/Acute Myeloid Leukemia
    Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
    Blood 2015 Nov 26;126(22):2484-90
  • Optimizing Cancer Genome Sequencing and Analysis
    Griffith M, Miller CA, Griffith OL, Krysiak K, Skidmore ZL, Ramu A, Walker JR, Dang HX, Trani L, Larson DE, Demeter RT, Wendl MC, McMichael JF, Austin RE, Magrini V, McGrath SD, Ly A, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Maher CA, Ding L, Klco JM, Mardis ER, Ley TJ, Wilson RK
    Cell Syst 2015 Sep 23;1(3):210-223
  • Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
    Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    JAMA 2015 Aug 25;314(8):811-822
  • Whole Exome Sequencing Reveals the Order of Genetic Changes During Malignant Transformation and Metastasis in a Single Patient With NF1-Plexiform Neurofibroma
    Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
    Clin Cancer Res 2015 Sep 15;21(18):4201-11
  • Genetic Heterogeneity of Induced Pluripotent Stem Cells: Results From 24 Clones Derived From a Single C57BL/6 Mouse
    Li C, Klco JM, Helton NM, George DR, Mudd JL, Miller CA, Lu C, Fulton R, O'Laughlin M, Fronick C, Wilson RK, Ley TJ
    PLoS One 2015 Mar 23;10(3):e0120585
  • Quantifying Ultra-Rare Pre-Leukemic Clones Via Targeted Error-Corrected Sequencing
    Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE
    Leukemia 2015 Jul;29(7):1608-1611
  • Epigenomic Analysis of the HOX Gene Loci Reveals Mechanisms That May Control Canonical Expression Patterns in AML and Normal Hematopoietic Cells
    Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ
    Leukemia 2015 Jun;29(6):1279-1289
  • U2AF1 Mutations Alter Sequence Specificity of Pre-mRNA Binding and Splicing
    Okeyo-Owuor T, White BS, Chatrikhi R, Mohan DR, Kim S, Griffith M, Ding L, Ketkar-Kulkarni S, Hundal J, Laird KM, Kielkopf CL, Ley TJ, Walter MJ, Graubert TA
    Leukemia 2015 Apr;29(4):909-917
  • Clonal Evolution Revealed by Whole Genome Sequencing in a Case of Primary Myelofibrosis Transformed to Secondary Acute Myeloid Leukemia
    Engle EK, Fisher DA, Miller CA, McLellan MD, Fulton RS, Moore DM, Wilson RK, Ley TJ, Oh ST
    Leukemia 2015 Apr;29(4):869-876
  • Role of TP53 Mutations in the Origin and Evolution of Therapy-Related Acute Myeloid Leukaemia
    Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
    Nature 2015 Feb 26;518(7540):552-555
  • Clonal Architectures and Driver Mutations in Metastatic Melanomas
    Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, Sondak VK, Fields RC, Ley TJ, Mule JJ, Wilson RK, Weber JS
    PLoS One 2014 Nov 13;9(11):e111153
  • Caspase-9 Is Required for Normal Hematopoietic Development and Protection From Alkylator-Induced DNA Damage in Mice
    Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA
    Blood 2014 Dec 18;124(26):3887-95
  • Age-Related Mutations Associated With Clonal Hematopoietic Expansion and Malignancies
    Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, DiPersio JF, Chen F, Wilson RK, Ley TJ, Ding L
    Nat Med 2014 Dec;20(12):1472-1478
  • SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution
    Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L
    PLoS Comput Biol 2014 Aug 7;10(8):e1003665
  • Primary Acute Myeloid Leukemia Cells With IDH1 or IDH2 Mutations Respond to a DOT1L Inhibitor in Vitro
    Sarkaria SM, Christopher MJ, Klco JM, Ley TJ
    Leukemia 2014 Dec;28(12):2403-6
  • Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing
    Hughes AE, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, DiPersio JF, Mardis ER, Wilson RK, Ley TJ, Walter MJ, Graubert TA
    PLoS Genet 2014 Jul 10;10(7):e1004462
  • The R882H DNMT3A Mutation Associated With AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers
    Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ
    Cancer Cell 2014 Apr 14;25(4):442-54
  • Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
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    J Clin Invest 2009 Jun;119(6):1714-26
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    Blood 2009 Jun 11;113(24):6206-14
  • Sociology. The Gender Gap in NIH Grant Applications
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    Science 2008 Dec 5;322(5907):1472-4
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    Blood 2008 Aug 15;112(4):1434-42
  • WuHMM: A Robust Algorithm to Detect DNA Copy Number Variation Using Long Oligonucleotide Microarray Data
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    Nucleic Acids Res 2008 Apr;36(7):e41
  • Computational Identification of the Normal and Perturbed Genetic Networks Involved in Myeloid Differentiation and Acute Promyelocytic Leukemia
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  • Somatic Mutations and Germline Sequence Variants in the Expressed Tyrosine Kinase Genes of Patients With De Novo Acute Myeloid Leukemia
    Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont D, McLellan MD, Payton JE, Westervelt P, Dipersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ
    Blood 2008 May 1;111(9):4797-808
  • Identification of Somatic JAK1 Mutations in Patients With Acute Myeloid Leukemia
    Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, Dipersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, Heath SE, Naggarajan R, Mardis ER, Wilson RK, Ley TJ, Tomasson MH
    Blood 2008 May 1;111(9):4809-12
  • Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
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    Immunity 2007 Oct 26;27(4):635-646
  • Distinct Patterns of Mutations Occurring in De Novo AML Versus AML Arising in the Setting of Severe Congenital Neutropenia
    Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, Bellanne-Chantelot C, Vardiman JW, Caligiuri MA, Bloomfield CD, DiPersio JF, Tomasson MH, Graubert TA, Westervelt P, Watson M, Shannon W, Baty J, Mardis ER, Wilson RK, Ley TJ
    Blood 2007 Sep 1;110(5):1648-55
  • Acquisition of Murine NK Cell Cytotoxicity Requires the Translation of a Pre-Existing Pool of Granzyme B and Perforin mRNAs
    Fehniger TA, Cai SF, Cao X, Bredemeyer AJ, Presti RM, French AR, Ley TJ
    Immunity 2007 Jun;26(6):798-811
  • A High-Resolution Map of Segmental DNA Copy Number Variation in the Mouse Genome
    Graubert TA, Cahan P, Edwin D, Selzer RR, Richmond TA, Eis PS, Shannon WD, Li X, McLeod HL, Cheverud JM, Ley TJ
    PLoS Genet 2007 Jan 5;3(1):e3
  • Commonly Dysregulated Genes in Murine APL Cells
    Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ
    Blood 2007 Feb 1;109(3):961-70
  • Expression of a Bcr-1 Isoform of RARalpha-PML Does Not Affect the Penetrance of Acute Promyelocytic Leukemia or the Acquisition of an Interstitial Deletion on Mouse Chromosome 2
    Walter MJ, Ries RE, Armstrong JR, Park JS, Mardis ER, Ley TJ
    Blood 2007 Feb 1;109(3):1237-40
  • Hop Cleavage and Function in Granzyme B-Induced Apoptosis
    Bredemeyer AJ, Carrigan PE, Fehniger TA, Smith DF, Ley TJ
    J Biol Chem 2006 Dec 1;281(48):37130-41
  • Cold Shock Domain Family Members YB-1 and MSY4 Share Essential Functions During Murine Embryogenesis
    Lu ZH, Books JT, Ley TJ
    Mol Cell Biol 2006 Nov;26(22):8410-7
  • Oncogenic K-Ras Cooperates With PML-RAR Alpha to Induce an Acute Promyelocytic Leukemia-Like Disease
    Chan IT, Kutok JL, Williams IR, Cohen S, Moore S, Shigematsu H, Ley TJ, Akashi K, Le Beau MM, Gilliland DG
    Blood 2006 Sep 1;108(5):1708-15
  • The Physician-Scientist Career Pipeline in 2005: Build It, and They Will Come
    Ley TJ, Rosenberg LE
    JAMA 2005 Sep 21;294(11):1343-51
  • Reduced PU.1 Expression Causes Myeloid Progenitor Expansion and Increased Leukemia Penetrance in Mice Expressing PML-RARalpha
    Walter MJ, Park JS, Ries RE, Lau SK, McLellan M, Jaeger S, Wilson RK, Mardis ER, Ley TJ
    Proc Natl Acad Sci U S A 2005 Aug 30;102(35):12513-8
  • Murine Acute Promyelocytic Leukemia Cells Can Be Recognized and Cleared in Vivo by Adaptive Immune Mechanisms
    Pollock JL, Lane AA, Schrimpf K, Ley TJ
    Haematologica 2005 Aug;90(8):1042-9
  • YB-1 Is Important for Late-Stage Embryonic Development, Optimal Cellular Stress Responses, and the Prevention of Premature Senescence
    Lu ZH, Books JT, Ley TJ
    Mol Cell Biol 2005 Jun;25(11):4625-37
  • Neutrophil Elastase Is Important for PML-Retinoic Acid Receptor Alpha Activities in Early Myeloid Cells
    Lane AA, Ley TJ
    Mol Cell Biol 2005 Jan;25(1):23-33
  • Granzyme B and the Downstream Granzymes C And/Or F Are Important for Cytotoxic Lymphocyte Functions
    Revell PA, Grossman WJ, Thomas DA, Cao X, Behl R, Ratner JA, Lu ZH, Ley TJ
    J Immunol 2005 Feb 15;174(4):2124-31
  • Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
    Grossman WJ, Verbsky JW, Barchet W, Colonna M, Atkinson JP, Ley TJ
    Immunity 2004 Oct;21(4):589-601
  • Papillon-Lefevre Syndrome: Correlating the Molecular, Cellular, and Clinical Consequences of Cathepsin C/Dipeptidyl Peptidase I Deficiency in Humans
    Pham CT, Ivanovich JL, Raptis SZ, Zehnbauer B, Ley TJ
    J Immunol 2004 Dec 15;173(12):7277-81
  • Expression Profiling of Murine Acute Promyelocytic Leukemia Cells Reveals Multiple Model-Dependent Progression Signatures
    Walter MJ, Park JS, Lau SK, Li X, Lane AA, Nagarajan R, Shannon WD, Ley TJ
    Mol Cell Biol 2004 Dec;24(24):10882-93
  • Granzymes and Caspase 3 Play Important Roles in Control of Gammaherpesvirus Latency
    Loh J, Thomas DA, Revell PA, Ley TJ, Virgin HW 4th
    J Virol 2004 Nov;78(22):12519-28
  • Differential Expression of Granzymes a and B in Human Cytotoxic Lymphocyte Subsets and T Regulatory Cells
    Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ
    Blood 2004 Nov 1;104(9):2840-8
  • A Proteomic Approach for the Discovery of Protease Substrates
    Bredemeyer AJ, Lewis RM, Malone JP, Davis AE, Gross J, Townsend RR, Ley TJ
    Proc Natl Acad Sci U S A 2004 Aug 10;101(32):11785-90
  • Granzymes a and B Are Not Expressed in Human Neutrophils
    Grossman WJ, Ley TJ
    Blood 2004 Aug 1;104(3):906-7; author reply 907-8
  • Neutrophil Elastase Cleaves PML-RARalpha and Is Important for the Development of Acute Promyelocytic Leukemia in Mice
    Lane AA, Ley TJ
    Cell 2003 Oct 31;115(3):305-18
  • A Pilot Study of High-Throughput, Sequence-Based Mutational Profiling of Primary Human Acute Myeloid Leukemia Cell Genomes
    Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, Heath S, Vardiman JW, Caligiuri MA, Bloomfield CD, Milbrandt JD, Mardis ER, Wilson RK
    Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14275-80
  • High-Penetrance Mouse Model of Acute Promyelocytic Leukemia With Very Low Levels of PML-RARalpha Expression
    Westervelt P, Lane AA, Pollock JL, Oldfather K, Holt MS, Zimonjic DB, Popescu NC, DiPersio JF, Ley TJ
    Blood 2003 Sep 1;102(5):1857-65
  • Long Targeting Arms Do Not Increase the Efficiency of Homologous Recombination in the Beta-Globin Locus of Murine Embryonic Stem Cells
    Lu ZH, Books JT, Kaufman RM, Ley TJ
    Blood 2003 Aug 15;102(4):1531-3
  • Cell Death Induced by Granzyme C
    Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ
    Blood 2003 Apr 15;101(8):3093-101
  • PML/RARalpha and FLT3-ITD Induce an APL-Like Disease in a Mouse Model
    Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, Ley TJ, Gilliland DG
    Proc Natl Acad Sci U S A 2002 Jun 11;99(12):8283-8
  • Adaptive Immunity Cooperates With Liposomal All-Trans-Retinoic Acid (ATRA) to Facilitate Long-Term Molecular Remissions in Mice With Acute Promyelocytic Leukemia
    Westervelt P, Pollock JL, Oldfather KM, Walter MJ, Ma MK, Williams A, DiPersio JF, Ley TJ
    Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9468-73
  • Removing Career Obstacles for Young Physician-Scientists -- Loan-Repayment Programs
    Ley TJ, Rosenberg LE
    N Engl J Med 2002 Jan 31;346(5):368-72
  • Granzyme B Can Cause Mitochondrial Depolarization and Cell Death in the Absence of BID, BAX, and BAK
    Thomas DA, Scorrano L, Putcha GV, Korsmeyer SJ, Ley TJ
    Proc Natl Acad Sci U S A 2001 Dec 18;98(26):14985-90
  • Dipeptidyl Peptidase I Is Essential for Activation of Mast Cell Chymases, but Not Tryptases, in Mice
    Wolters PJ, Pham CT, Muilenburg DJ, Ley TJ, Caughey GH
    J Biol Chem 2001 May 25;276(21):18551-6
  • Lack of Neighborhood Effects From a Transcriptionally Active Phosphoglycerate Kinase-Neo Cassette Located Between the Murine Beta-Major and Beta-Minor Globin Genes
    Kaufman RM, Lu ZH, Behl R, Holt JM, Ackers GK, Ley TJ
    Blood 2001 Jul 1;98(1):65-73
  • Sudden Death Among Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide
    Westervelt P, Brown RA, Adkins DR, Khoury H, Curtin P, Hurd D, Luger SM, Ma MK, Ley TJ, DiPersio JF
    Blood 2001 Jul 15;98(2):266-71
  • Acquired, Nonrandom Chromosomal Abnormalities Associated With the Development of Acute Promyelocytic Leukemia in Transgenic Mice
    Zimonjic DB, Pollock JL, Westervelt P, Popescu NC, Ley TJ
    Proc Natl Acad Sci U S A 2000 Nov 21;97(24):13306-11
  • DFF45/ICAD Can Be Directly Processed by Granzyme B During the Induction of Apoptosis
    Thomas DA, Du C, Xu M, Wang X, Ley TJ
    Immunity 2000 Jun;12(6):621-32
  • Deletions Within the Mouse Beta-Globin Locus Control Region Preferentially Reduce Beta(Min) Globin Gene Expression
    Alami R, Bender MA, Feng YQ, Fiering SN, Hug BA, Ley TJ, Groudine M, Bouhassira EE
    Genomics 2000 Feb 1;63(3):417-24
  • Independent Formation of DnaseI Hypersensitive Sites in the Murine Beta-Globin Locus Control Region
    Bender MA, Mehaffey MG, Telling A, Hug B, Ley TJ, Groudine M, Fiering S
    Blood 2000 Jun 1;95(11):3600-4
  • The Physician-Scientist: Career Issues and Challenges at the Year 2000
    Zemlo TR, Garrison HH, Partridge NC, Ley TJ
    FASEB J 2000 Feb;14(2):221-30
  • A Bcr-3 Isoform of RARalpha-PML Potentiates the Development of PML-RARalpha-Driven Acute Promyelocytic Leukemia
    Pollock JL, Westervelt P, Kurichety AK, Pelicci PG, Grisolano JL, Ley TJ
    Proc Natl Acad Sci U S A 1999 Dec 21;96(26):15103-8
  • Normal Neutrophil Function in Cathepsin G-Deficient Mice
    MacIvor DM, Shapiro SD, Pham CT, Belaaouaj A, Abraham SN, Ley TJ
    Blood 1999 Dec 15;94(12):4282-93
  • Transgenic Analysis of a 100-Kb Human Beta-Globin Cluster-Containing DNA Fragment Propagated as a Bacterial Artificial Chromosome [Published Erratum Appears in Blood 2000 Feb 1;95(3):744]
    Kaufman RM, Pham CT, Ley TJ
    Blood 1999 Nov 1;94(9):3178-84
  • Dipeptidyl Peptidase I Is Required for the Processing and Activation of Granzymes A and B in Vivo
    Pham CT, Ley TJ
    Proc Natl Acad Sci U S A 1999 Jul 20;96(15):8627-32
  • Granzyme a Initiates an Alternative Pathway for Granule-Mediated Apoptosis
    Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ
    Immunity 1999 May;10(5):595-605
  • The 5' Flanking Region of the Human Granzyme H Gene Directs Expression to T/Natural Killer Cell Progenitors and Lymphokine-Activated Killer Cells in Transgenic Mice
    MacIvor DM, Pham CT, Ley TJ
    Blood 1999 Feb 1;93(3):963-73
  • Augmented Inflammatory Responses and Altered Wound Healing in Cathepsin G-Deficient Mice
    Abbott RE, Corral CJ, MacIvor DM, Lin X, Ley TJ, Mustoe TA
    Arch Surg 1998 Sep;133(9):1002-6
  • Stochastic, Stage-Specific Mechanisms Account for the Variegation of a Human Globin Transgene
    Graubert TA, Hug BA, Wesselschmidt R, Hsieh CL, Ryan TM, Townes TM, Ley TJ
    Nucleic Acids Res 1998 Jun 15;26(12):2849-58
  • Mice Lacking Neutrophil Elastase Reveal Impaired Host Defense Against Gram Negative Bacterial Sepsis
    Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, Shapiro SD
    Nat Med 1998 May;4(5):615-8
  • Production of Fully Active Recombinant Murine Granzyme B in Yeast
    Pham CT, Thomas DA, Mercer JD, Ley TJ
    J Biol Chem 1998 Jan 16;273(3):1629-33
  • Perforin/Granzyme-Dependent and Independent Mechanisms Are Both Important for the Development of Graft-Versus-Host Disease After Murine Bone Marrow Transplantation
    Graubert TA, DiPersio JF, Russell JH, Ley TJ
    J Clin Invest 1997 Aug 15;100(4):904-11
  • Residual Cytotoxicity and Granzyme K Expression in Granzyme A-Deficient Cytotoxic Lymphocytes
    Shresta S, Goda P, Wesselschmidt R, Ley TJ
    J Biol Chem 1997 Aug 8;272(32):20236-44
  • Mechanisms Responsible for Granzyme B-Independent Cytotoxicity
    Shresta S, Russell JH, Ley TJ
    Blood 1997 Jun 1;89(11):4085-91
  • Molecular Cloning, Chromosomal Localization, and Expression of Murine Dipeptidyl Peptidase I
    Pham CTN, Armstrong RJ, Zimonjic DB, Popescu NC, Payan DG, Ley TJ
    J Biol Chem 1997 Apr 18;272(16):10695-703
  • Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RAR Alpha Under Control of Cathepsin G Regulatory Sequences
    Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ
    Blood 1997 Jan 15;89(2):376-87
  • Long-Range Disruption of Gene Expression by a Selectable Marker Cassette
    Pham CT, MacIvor DM, Hug BA, Heusel JW, Ley TJ
    Proc Natl Acad Sci U S A 1996 Nov 12;93(23):13090-5
  • Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation
    Darmon AJ, Ley TJ, Nicholson DW, Bleackley RC
    J Biol Chem 1996 Sep 6;271(36):21709-12
  • Metalloelastase Is Required for Macrophage-Mediated Proteolysis and Matrix Invasion in Mice
    Shipley JM, Wesselschmidt RL, Kobayashi DK, Ley TJ, Shapiro SD
    Proc Natl Acad Sci U S A 1996 Apr 30;93(9):3942-6
  • Analysis of Mice Containing a Targeted Deletion of Beta-Globin Locus Control Region 5' Hypersensitive Site 3
    Hug BA, Wesselschmidt RL, Fiering S, Bender MA, Epner E, Groudine M, Ley TJ
    Mol Cell Biol 1996 Jun;16(6):2906-12
  • The Role of Granzyme B in Murine Models of Acute Graft-Versus-Host Disease and Graft Rejection
    Graubert TA, Russell JH, Ley TJ
    Blood 1996 Feb 15;87(4):1232-7
  • An Intramolecular Triplex in the Human Gamma-Globin 5'-Flanking Region Is Altered by Point Mutations Associated With Hereditary Persistence of Fetal Hemoglobin
    Bacolla A, Ulrich MJ, Larson JE, Ley TJ, Wells RD
    J Biol Chem 1995 Oct 13;270(41):24556-63
  • Targeted Deletion of 5'HS2 of the Murine Beta-Globin LCR Reveals That It Is Not Essential for Proper Regulation of the Beta-Globin Locus
    Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DI, Enver T, Ley TJ, Groudine M
    Genes Dev 1995 Sep 15;9(18):2203-13
  • Natural Killer and Lymphokine-Activated Killer Cells Require Granzyme B for the Rapid Induction of Apoptosis in Susceptible Target Cells
    Shresta S, MacIvor DM, Heusel JW, Russell JH, Ley TJ
    Proc Natl Acad Sci U S A 1995 Jun 6;92(12):5679-83
  • Development of Leukemia in Mice Transgenic for the Tax Gene of Human T- Cell Leukemia Virus Type I
    Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L
    Proc Natl Acad Sci U S A 1995 Feb 14;92(4):1057-61
  • Early Myeloid Cell-Specific Expression of the Human Cathepsin G Gene in Transgenic Mice
    Grisolano JL, Sclar GM, Ley TJ
    Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8989-93
  • A Human Protein Containing a "Cold Shock" Domain Binds Specifically to H-DNA Upstream From the Human Gamma-Globin Genes
    Horwitz EM, Maloney KA, Ley TJ
    J Biol Chem 1994 May 13;269(19):14130-9
  • Cytotoxic Lymphocytes Require Granzyme B for the Rapid Induction of DNA Fragmentation and Apoptosis in Allogeneic Target Cells
    Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ
    Cell 1994 Mar 25;76(6):977-87
  • Cloning and Characterization of a Unique Elastolytic Metalloproteinase Produced by Human Alveolar Macrophages
    Shapiro SD, Kobayashi DK, Ley TJ
    J Biol Chem 1993 Nov 15;268(32):23824-9
  • Consensus AP-1 and CRE Motifs Upstream From the Human Cytotoxic Serine Protease B (CSP-B/CGL-1) Gene Synergize to Activate Transcription
    Hanson RD, Grisolano JL, Ley TJ
    Blood 1993 Nov 1;82(9):2749-57
  • Molecular Mechanisms Regulating the Production of Collagenase and TIMP in U937 Cells: Evidence for Involvement of Delayed Transcriptional Activation and Enhanced mRNA Stability
    Shapiro SD, Doyle GA, Ley TJ, Parks WC, Welgus HG
    Biochemistry 1993 Apr 27;32(16):4286-92
  • The Human Mast Cell Chymase Gene (CMA1): Mapping to the Cathepsin G/Granzyme Gene Cluster and Lineage-Restricted Expression
    Caughey GH, Schaumberg TH, Zerweck EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ
    Genomics 1993 Mar;15(3):614-20
  • Molecular Cloning, Chromosomal Location, and Tissue-Specific Expression of the Murine Cathepsin G Gene
    Heusel JW, Scarpati EM, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro SD, Ley TJ
    Blood 1993 Mar 15;81(6):1614-23
  • Structure and Function of the Murine Beta-Globin Locus Control Region 5' HS-3
    Hug BA, Moon AM, Ley TJ
    Nucleic Acids Res 1992 Nov 11;20(21):5771-8
  • An Intramolecular DNA Triplex Is Disrupted by Point Mutations Associated With Hereditary Persistence of Fetal Hemoglobin
    Ulrich MJ, Gray WJ, Ley TJ
    J Biol Chem 1992 Sep 15;267(26):18649-58
  • Characterization of the 5' Untranslated Region of the Human c-Fgr Gene and Identification of the Major Myelomonocytic c-Fgr Promoter
    Link DC, Gutkind SJ, Robbins KC, Ley TJ
    Oncogene 1992 May;7(5):877-84
  • Molecular Cloning, Chromosomal Localization, and Bacterial Expression of a Murine Macrophage Metalloelastase
    Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ
    J Biol Chem 1992 Mar 5;267(7):4664-71
  • A-T-Rich Scaffold Attachment Regions Flank the Hematopoietic Serine Protease Genes Clustered on Chromosome 14q11.2
    Hanson RD, Ley TJ
    Blood 1992 Feb 1;79(3):610-8
  • The 5'-Flanking Region of the Human CGL-1/Granzyme B Gene Targets Expression of a Reporter Gene to Activated T-Lymphocytes in Transgenic Mice
    Hanson RD, Sclar GM, Kanagawa O, Ley TJ
    J Biol Chem 1991 Dec 25;266(36):24433-8
  • 1,25-Dihydroxyvitamin D3 Induces Monocytic Differentiation of the PLB-985 Leukemic Line and Promotes c-Fgr mRNA Expression
    Perkins SL, Link DC, Kling S, Ley TJ, Teitelbaum SL
    J Leukoc Biol 1991 Nov;50(5):427-33
  • Functional Properties of the Beta-Globin Locus Control Region in K562 Erythroleukemia Cells
    Moon AM, Ley TJ
    Blood 1991 May 15;77(10):2272-84
  • Structure and Expression of a Cluster of Human Hematopoietic Serine Protease Genes Found on Chromosome 14q11.2
    Heusel JW, Hanson RD, Silverman GA, Ley TJ
    J Biol Chem 1991 Apr 5;266(10):6152-8
  • A Novel c-Fgr Exon Utilized in Epstein-Barr Virus-Infected B Lymphocytes but Not in Normal Monocytes
    Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC
    Mol Cell Biol 1991 Mar;11(3):1500-7
  • Transcriptional Activation of the Human Cytotoxic Serine Protease Gene CSP-B in T Lymphocytes
    Hanson RD, Ley TJ
    Mol Cell Biol 1990 Nov;10(11):5655-62
  • Conservation of the Primary Structure, Organization, and Function of the Human and Mouse Beta-Globin Locus-Activating Regions
    Moon AM, Ley TJ
    Proc Natl Acad Sci U S A 1990 Oct;87(19):7693-7
  • Function of Normal and Mutated Gamma-Globin Gene Promoters in Electroporated K562 Erythroleukemia Cells
    Ulrich MJ, Ley TJ
    Blood 1990 Feb 15;75(4):990-9
  • A Cluster of Hematopoietic Serine Protease Genes Is Found on the Same Chromosomal Band as the Human Alpha/Delta T-Cell Receptor Locus
    Hanson RD, Hohn PA, Popescu NC, Ley TJ
    Proc Natl Acad Sci U S A 1990 Feb;87(3):960-3
  • Developmental Regulation of the Human Cathepsin G Gene in Myelomonocytic Cells
    Hanson RD, Connolly NL, Burnett D, Campbell EJ, Senior RM, Ley TJ
    J Biol Chem 1990 Jan 25;265(3):1524-30
  • Nucleotide Sequence and Regulation of a Human 90-KDa Heat Shock Protein Gene
    Rebbe NF, Hickman WS, Ley TJ, Stafford DW, Hickman S
    J Biol Chem 1989 Sep 5;264(25):15006-11
  • Analysis of Epitope Expression and the Functional Repertoire of Recombinant Complement Receptor 2 (CR2/CD21) in Mouse and Human Cells
    Carel JC, Frazier B, Ley TJ, Holers VM
    J Immunol 1989 Aug 1;143(3):923-30
  • Genomic Organization and Chromosomal Localization of the Human Cathepsin G Gene
    Hohn PA, Popescu NC, Hanson RD, Salvesen G, Ley TJ
    J Biol Chem 1989 Aug 15;264(23):13412-9
  • Globin Gene Expression in Erythroid Human Fetal Liver Cells
    Ley TJ, Maloney KA, Gordon JI, Schwartz AL
    J Clin Invest 1989 Mar;83(3):1032-8
  • Tissue-Specific Expression and Developmental Regulation of the Human Fgr Proto-Oncogene
    Ley TJ, Connolly NL, Katamine S, Cheah MS, Senior RM, Robbins KC
    Mol Cell Biol 1989 Jan;9(1):92-9
  • High-Resolution Analysis of the Human Gamma-Globin Gene Promoter in K562 Erythroleukemia Cell Chromatin
    Gimble JM, Max EE, Ley TJ
    Blood 1988 Aug;72(2):606-12
  • An Enhancer Element Lies 3' to the Human a Gamma Globin Gene
    Bodine DM, Ley TJ
    EMBO J 1987 Oct;6(10):2997-3004
  • Hydroxyurea Induction of Hemoglobin F Production in Sickle Cell Disease: Relationship Between Cytotoxicity and F Cell Production
    Dover GJ, Humphries RK, Moore JG, Ley TJ, Young NS, Charache S, Nienhuis AW
    Blood 1986 Mar;67(3):735-8
  • Fgr Proto-Oncogene mRNA Induced in B Lymphocytes by Epstein-Barr Virus Infection
    Cheah MS, Ley TJ, Tronick SR, Robbins KC
    Nature 1986 Jan 16-22;319(6050):238-40
  • 5-Azacytidine Acts Directly on Both Erythroid Precursors and Progenitors to Increase Production of Fetal Hemoglobin
    Humphries RK, Dover G, Young NS, Moore JG, Charache S, Ley T, Nienhuis AW
    J Clin Invest 1985 Feb;75(2):547-57
  • Disseminated Infection Caused by Cunninghamella Bertholletiae in a Patient With Beta-Thalassemia. Case Report and Review of the Literature
    Sands JM, Macher AM, Ley TJ, Nienhuis AW
    Ann Intern Med 1985 Jan;102(1):59-63
  • DNA Methylation and Regulation of the Human Beta-Globin-Like Genes in Mouse Erythroleukemia Cells Containing Human Chromosome 11
    Ley TJ, Chiang YL, Haidaris D, Anagnou NP, Wilson VL, Anderson WF
    Proc Natl Acad Sci U S A 1984 Nov;81(21):6618-22
  • Beta O-39 Thalassemia Gene: A Premature Termination Codon Causes Beta- mRNA Deficiency Without Affecting Cytoplasmic Beta-mRNA Stability
    Humphries RK, Ley TJ, Anagnou NP, Baur AW, Nienhuis AW
    Blood 1984 Jul;64(1):23-32
  • Human Globin Gene Expression in Hybrid 2S MEL X Human Fibroblast Cells
    Chiang YL, Ley TJ, Sanders-Haigh L, Anderson WF
    Somat Cell Mol Genet 1984 Jul;10(4):399-407
  • Inducible Transcription of Five Globin Genes in K562 Human Leukemia Cells
    Dean A, Ley TJ, Humphries RK, Fordis M, Schechter AN
    Proc Natl Acad Sci U S A 1983 Sep;80(18):5515-9
  • Acquired Alpha-Thalassemia in Preleukemia Is Due to Decreased Expression of All Four Alpha-Globin Genes
    Anagnou NP, Ley TJ, Chesbro B, Wright G, Kitchens C, Liebhaber S, Nienhuis AW, Deisseroth AB
    Proc Natl Acad Sci U S A 1983 Oct;80(19):6051-5
  • "Silent" Nucleotide Substitution in a Beta+-Thalassemia Globin Gene Activates Splice Site in Coding Sequence RNA
    Goldsmith ME, Humphries RK, Ley T, Cline A, Kantor JA, Nienhuis AW
    Proc Natl Acad Sci U S A 1983 Apr;80(8):2318-22
  • 5-Azacytidine Increases Gamma-Globin Synthesis and Reduces the Proportion of Dense Cells in Patients With Sickle Cell Anemia
    Ley TJ, DeSimone J, Noguchi CT, Turner PH, Schechter AN, Heller P, Nienhuis AW
    Blood 1983 Aug;62(2):370-80
  • A Weak Upstream Promoter Gives Rise to Long Human Beta-Globin RNA Molecules
    Ley TJ, Nienhuis AW
    Biochem Biophys Res Commun 1983 May 16;112(3):1041-8
  • 5-Azacytidine Selectively Increases Gamma-Globin Synthesis in a Patient With Beta+ Thalassemia
    Ley TJ, DeSimone J, Anagnou NP, Keller GH, Humphries RK, Turner PH, Young NS, Keller P, Nienhuis AW
    N Engl J Med 1982 Dec 9;307(24):1469-75
  • Spontaneous Subarachnoid Hemorrhage Simulating Acute Transmural Myocardial Infarction
    Gascon P, Ley TJ, Toltzis RJ, Bonow RO
    Am Heart J 1983 Mar;105(3):511-3
  • RNA Processing Errors in Patients With Beta-Thalassemia
    Ley TJ, Anagnou NP, Pepe G, Nienhuis AW
    Proc Natl Acad Sci U S A 1982 Aug;79(15):4775-9
  • Differences in Human Alpha-, Beta- and Delta-Globin Gene Expression in Monkey Kidney Cells
    Humphries RK, Ley T, Turner P, Moulton AD, Nienhuis AW
    Cell 1982 Aug;30(1):173-83

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