Gregory D. Longmore, MD

Gregory D. Longmore, MD

Professor; Section Co-Director – Molecular Oncology

Address:
BJCIH 7th floor ICCE Institute
Mail Stop 8069-0004-07
Washington University
660 South Euclid Avenue
St. Louis, MO 63110

Room 7627 BJC Institute of Health (office)
Room 7311 BJC Institute of Health (lab)

Research Interests
  • Epithelia morphogenesis
  • Cancer metastasis
Research

People rarely die from their primary tumor, rather it is the spread of their tumor to other organs (metastasis) that leads to death, and when that occurs there is a general lack of treatment options. Crosstalk between tumor cells and their associated cellular, physical, and chemical environment is now appreciated to be critical for tumor progression, metastasis, and response to therapy, yet the cellular and molecular basis for these tumor-environment communications is complex and not fully understood. Our lab is interested in understanding how cancers invade and spread throughout the body with the goal to identify and understand molecular pathways important for metastasis and then develop effective and selective ways to prevent the spread of cancer by targeting these pathways. To address this problem we employ aspects of biochemistry, cell biology, developmental biology, biophysics, genetics, and cell and in vivo imaging.

Longmore Lab
Profiles (publications)

Biosketch

Education

  • 1993-1989: Postdoctoral Research Fellow, Cell Biology, Massachusetts Institute of Technology, Cambridge, MA
  • 1990-1983: Clinical Fellow, Internal Medicine, Hematology &Oncology, Harvard Medical School, Boston, MA
  • 1983-1979: MD, McGill University, Montreal, Quebec
  • 1979-1977: MSc in Biochemistry, University of Toronto, Toronto, Ontario
  • 1977-1973: BSc (Honours) in Biochemistry, University of Western Ontario, London, Ontario

Academic Positions & Employment

  • present-2007: Professor of Medicine and Cell Biology, Washington University, St. Louis, MO
  • 2007-1998: Associate Professor of Medicine and Cell Biology, Washington University, St. Louis, MO
  • 1998-1993: Assistant Professor of Medicine and Cell Biology, Washington University, St. Louis, MO
  • 1992-1990: Instructor in Medicine, Harvard Medical School, Boston, MA
  • 1992-1988: Postdoctoral Research Fellow, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA (laboratory of Dr. Harvey Lodish)
  • 1990-1987: Clinical Fellow in Medicine, Harvard Medical School, Brigham and Women’s Hospital (Hematology) and Dana Farber Cancer Institute (Medical Oncology), Boston, MA
  • 1986-1985: Visiting Scientist, Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA (laboratory of Dr. Herman Eisen)
  • 1986-1983: Clinical Fellow in Internal Medicine, Harvard Medical School, New England Deaconess Hospital (now Beth Israel-Deaconess Hospitals), Boston, MA
  • 1980-1977: Predoctoral Student, Department of Biochemistry, University of Toronto, Ontario (laboratory of Dr. Harry Schachter)

Appointments & Committees

  • present-2017: Co-Director, Molecular Oncology Section, Oncology Division, Department of Medicine, Washington University, St. Louis, MO
  • present-2016: Barnes-Jewish Christian (BJC) Investigator Program Committee
  • present-2016: Washington University Institutional Conflict of Interest Review Committee
  • present-2013: Director, ICCE Institute, Washington University, St. Louis MO
  • present-2010: Co-Director, C4 Basic Research Program, Siteman Cancer Center, Washington University, St. Louis, MO
  • present-2003: Member, Siteman Cancer Center, Washington University, St. Louis, MO
  • 2017-2009: Member, Medical Scientist Training Program (MD/PhD) Admissions Committee, Washington University, St. Louis, MO
  • 2015-2011: Co-Director, Molecular Oncology Section, Oncology Division, Department of Medicine, Washington University, St Louis, MO
  • 2010-2003: Molecular Cell Biology Steering Committee, Division of Biology and Biomedical Sciences, Washington University, St. Louis, MO
  • 2001-1999: Four Schools Program (Washington University, Duke University, University of Pennsylvania, and Johns Hopkins University), Washington University representative
  • 2000-1996: Developmental Biology Steering Committee, Division of Biology and Biomedical Sciences, Washington University, St. Louis, MO
  • 1998-1994: Admissions Committee (PhD), Division of Biology and Biomedical Sciences (DBBS), Washington University, St. Louis, MO
  • 1995-1993: Compton Scholar Award for entering undergraduates, Natural Sciences and Liberal Arts, Washington University, St. Louis, MO
  • 1983: Co-Chairperson, Curriculum Review Committee, McGill Medical School
  • 1987-1986: Institutional Review Board, New England Deaconess Hospital, Boston, MA

Board Certification

  • 1989: Diplomate, American Board of Medical Oncology
  • 1986: Diplomate, American Board of Internal Medicine

Honors & Awards

  • 2014: Blaffer Lecture, M.D. Anderson Cancer Center, Houston TX
  • 2001: Invited Visiting Professor, Department of Pediatrics, University of Helsinki, Finland
  • 2000: Elected Member of American Society for Clinical Investigation
  • 2003-1999: Established Investigator, American Heart Association
  • 2001-1998: Edward Mallinckrodt, Jr. Foundation Scholar
  • 1995-1992: Career Development Award, James S. McDonnell Foundation for Molecular Oncology
  • 1992-1988: NIH Physician-Scientist Award AG00294
  • 1984: James L. Tullis Award, Harvard Medical School
  • 1981-1980: Faculty Scholarship Award, Department of Medicine, McGill University
  • 1979-1977: Medical Research Council of Canada Studentship

Editorial Responsibilities

  • present-2016: Editorial Board, BMC Biology
  • present-2013: Editorial Board, Molecular Cancer Research
  • present-2013: Member F1000 – Morphogenesis and Cell Biology
  • present-2007: Editorial Board, Molecular and Cellular Biology
  • 2010-2007: Associate Editor, Cancer Research

Grant Review Panels

  • present-2016: American Cancer Society: Council for Extramural Funding
  • present-2016: Cancer Research UK – External Review Panel
  • present-2000: NCI, NIGMS, and NHLBI – ~10 special emphasis panels, site visits, or internal program reviews
  • 2023-2017: NIH Tumor Promotion and Metastasis Study Section member
  • 2018: External Review: Northwestern University Lurie Cancer Center, Chicago, IL
  • 2015: NIH Tumor Promotion and Metastasis (TPM) Study Section – ad hoc
  • 2014: External Review: U. Wisconsin Carbone Cancer Center, TME research program
  • 2014-2010: NIH Tumor Microenvironment (TME) Study Section
    • Chairperson 2014-2012
  • 2013-2011: Cancer Prevention Research Institute of Texas (CPRIT) Peer Review Panel
  • 2010-2006: American Cancer Society (ACS) Cell Structure and Metastasis Review Panel
    • Chairperson 2010-2007
  • 2008-2004: Member, NIH/NCI-F Manpower and Training Study Section
  • 1999-1998: NIH Hematology II Study Section

Professional Societies

  • present-2008: American Association of Cancer Research
  • present-2007: The Epithelial-Mesenchymal Transition (EMT) International Association
  • present-2000: American Society for Clinical Investigation
  • present-2000: American Society for Cell Biology
  • present-1993: American Society for Microbiology
  • 2000-1995: American Society of Hematology