Faculty
Hematology Division
Alphabetical list (active faculty):   
Elaine M. Majerus

Elaine M. Majerus, MD, PhD

Professor

Department of Medicine

Hematology Division

Clinical Interests

  • Hemophilia and bleeding disorders
  • Thrombosis
  • Paroxysmal nocturnal hemoglobinuria
  • Atypical hemolytic uremic syndrome

Contact

  • 314-362-8814 (office)
  • 314-362-8813 (fax)
  • Hematology Division
    Mail Stop 8125-0022-01
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Suite 1101 Wohl Hospital (office)

Original Articles

  • Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A
    Ozelo MC, Mahlangu J, Pasi KJ, Giermasz A, Leavitt AD, Laffan M, Symington E, Quon DV, Wang JD, Peerlinck K, Pipe SW, Madan B, Key NS, Pierce GF, O'Mahony B, Kaczmarek R, Henshaw J, Lawal A, Jayaram K, Huang M, Yang X, Wong WY, Kim B
    GENEr8-1 Trial Group (Contributors include: Majerus E)

    N Engl J Med 2022 Mar 17;386(11):1013-1025
  • Microangiopathic Hemolytic Anemia
    Majerus E, Sadler JE
    In: Anemia: Pathophysiology, Diagnosis, and Management (Benz E, Berliner N, Schiffman F, eds.), pp 113-121, Cambridge: Cambridge University Press, 2017
  • Randomized Phase 2 Trial of Regadenoson for Treatment of Acute Vaso-Occlusive Crises in Sickle Cell Disease
    Field JJ, Majerus E, Gordeuk VR, Gowhari M, Hoppe C, Heeney MM, Achebe M, George A, Chu H, Sheehan B, Puligandla M, Neuberg D, Lin G, Linden J, Nathan DG
    Blood Adv 2017 Aug 28;1(20):1645-1649
  • NNKTT120, an Anti-INKT Cell Monoclonal Antibody, Produces Rapid and Sustained INKT Cell Depletion in Adults With Sickle Cell Disease
    Field JJ, Majerus E, Ataga KI, Vichinsky EP, Schaub R, Mashal R, Nathan DG
    PLoS One 2017 Feb 2;12(2):e0171067
  • Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism
    Vasudevan D, Takeuchi H, Johar SS, Majerus E, Haltiwanger RS
    Curr Biol 2015 Feb 2;25(3):286-95
  • Sickle Cell Vaso-Occlusion Causes Activation of INKT Cells That Is Decreased by the Adenosine A2A Receptor Agonist Regadenoson
    Field JJ, Lin G, Okam MM, Majerus E, Keefer J, Onyekwere O, Ross A, Campigotto F, Neuberg D, Linden J, Nathan DG
    Blood 2013 Apr 25;121(17):3329-34
  • Sickle Cell Disease (SCD), INKT Cells, and Regadenoson Infusion
    Nathan DG, Field J, Lin G, Neuberg D, Majerus E, Onyekwere O, Keefer J, Okam M, Ross A, Linden J
    Trans Am Clin Climatol Assoc 2012;123:312-7; discussion 317-8
  • Multi-Step Binding of ADAMTS-13 to Von Willebrand Factor
    Feys HB, Anderson PJ, Vanhoorelbeke K, Majerus EM, Sadler JE
    J Thromb Haemost 2009 Dec;7(12):2088-95
  • ADAMTS13 Bound to Endothelial Cells Exhibits Enhanced Cleavage of Von Willebrand Factor
    Vomund AN, Majerus EM
    J Biol Chem 2009 Nov 6;284(45):30925-32
  • Factor XI/ADAMTS13 Complexes Are Quantitatively Insignificant in Human Plasma
    Anderson PJ, Gailani D, Feys HB, Gao W, Majerus EM, Vanhoorelbeke K, Sadler JE
    Haematologica 2007 Oct;92(10):1419-22
  • O-Fucosylation Is Required for ADAMTS13 Secretion
    Ricketts LM, Dlugosz M, Luther KB, Haltiwanger RS, Majerus EM
    J Biol Chem 2007 Jun 8;282(23):17014-23
  • Exosite Interactions Contribute to Tension-Induced Cleavage of Von Willebrand Factor by the Antithrombotic ADAMTS13 Metalloprotease
    Gao W, Anderson PJ, Majerus EM, Tuley EA, Sadler JE
    Proc Natl Acad Sci U S A 2006 Dec 12;103(50):19099-104
  • Binding of ADAMTS13 to Von Willebrand Factor
    Majerus EM, Anderson PJ, Sadler JE
    J Biol Chem 2005 Jun 10;280(23):21773-8
  • Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity
    Majerus EM, Zheng X, Tuley EA, Sadler JE
    J Biol Chem 2003 Nov 21;278(47):46643-8
  • Cleavage of Von Willebrand Factor Requires the Spacer Domain of the Metalloprotease ADAMTS13
    Zheng X, Nishio K, Majerus EM, Sadler JE
    J Biol Chem 2003 Aug 8;278(32):30136-41
  • ADAMTS13 and TTP
    Zheng X, Majerus EM, Sadler JE
    Curr Opin Hematol 2002 Sep;9(5):389-94
  • Colorectal Malignances
    Majerus EM, Birnbaum E, Picus J
    In: The Washington Manual of Oncology, Lippincott Williams & Wilkins, Philadelphia, PA, pp 191-202, 2002
  • Structure of Von Willebrand Factor-Cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura
    Zheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, Fujikawa K
    J Biol Chem 2001 Nov 2;276(44):41059-63
  • Subcellular Localization and Targeting of Cathepsin E
    Finley EM, Kornfeld S
    J Biol Chem 1994 Dec 9;269(49):31259-66
  • Identification of Nucleotide Pyrophosphatase/Alkaline Phosphodiesterase I Activity Associated With the Mouse Plasma Cell Differentiation Antigen PC-1
    Rebbe NF, Tong BD, Finley EM, Hickman S
    Proc Natl Acad Sci U S A 1991 Jun 15;88(12):5192-6
  • The Effect of Peptide Deletions on the Glycosylation of Murine Immunoglobulin M Heavy Chains
    Finley EM, Rebbe NF, Hickman S
    Arch Biochem Biophys 1990 Jun;279(2):395-401