Faculty
Hematology Division
Philip W. Majerus, MD
July 10, 1936 - June 8, 2016
Professor (1966-2014)
Department of Medicine
Hematology Division
Department of Biochemistry & Molecular Biophysics
Original Articles
-
An aspirin a day
Adv Biol Regul 2014 Jan;54C:231-241 -
The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death
Adv Biol Regul 2012 Jan;52(1):282-289 -
Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8
Proc Natl Acad Sci U S A 2012 Jun 12;109(24):9539-44 -
Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation
Proc Natl Acad Sci U S A 2012 Feb 14;109(7):2290-5 -
Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans
Cell Metab 2011 Oct 5;14(4):466-77 -
The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model
Adv Enzyme Regul 2011;51(1):101-5 -
Wandering through the laboratory
J Biol Chem 2011 Feb 18;286(7):4941-5 -
Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects
Adv Enzyme Regul 2010;50(1):365-72 -
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
Proc Natl Acad Sci U S A 2010 Dec 21;107(51):22231-22236 -
INO-4995 therapeutic efficacy is enhanced with repeat dosing in cystic fibrosis knockout mice and human epithelia
Am J Respir Cell Mol Biol 2010 Jan;42(1):105-12 -
Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
Nat Genet 2009 Sep;41(9):1032-6 -
Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase
Proc Natl Acad Sci U S A 2009 Jun 16;106(24):9831-5 -
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
EMBO Rep 2009 May;10(5):487-93 -
Phosphoinositide phosphatases and disease
J Lipid Res 2009 Apr;50 Suppl:S249-54 -
MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis
J Biol Chem 2009 Jan 23;284(4):2064-71 -
The role of inositol signaling in the control of apoptosis
Adv Enzyme Regul 2008;48:10-7 -
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis
Proc Natl Acad Sci U S A 2007 Oct 23;104(43):16834-9 -
A discrete signaling function for an inositol pyrophosphate
Sci STKE 2007 Dec 11;2007(416):pe72 -
Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate
Biochem Biophys Res Commun 2006 Jan 6;339(1):209-16 -
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases
Proc Natl Acad Sci U S A 2005 Dec 27;102(52):18854-9 -
Increased levels of inositol hexakisphosphate (InsP6) protect HEK293 cells from tumor necrosis factor (alpha)- and Fas-induced apoptosis
J Biol Chem 2005 Aug 12;280(32):29263-8 -
Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression
Proc Natl Acad Sci U S A 2005 Jun 14;102(24):8448-53 -
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase
Mol Cell 2005 Apr 15;18(2):201-12 -
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
Mol Biol Cell 2005 May;16(5):2218-33 -
Blood coagulation and anticoagulant, thrombolytic, and antiplatelet drugs
In: "Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th Edition" (Brunton LL, Lazo JS, Parker KL, eds.), McGraw-Hill, New York, pp. 1467-1488 (2006) -
The pathway for the production of inositol hexakisphosphate in human cells
J Biol Chem 2005 Jan 21;280(3):1911-20 -
Blasts from the past
J Clin Invest 2004 Oct;114(8):1017-33 -
The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin
Proc Natl Acad Sci U S A 2004 Sep 14;101(37):13501-6 -
The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155
Mol Cell Proteomics 2004 Feb;3(2):145-55 -
Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis
J Biol Chem 2003 Oct 31;278(44):43645-53 -
Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9
Proc Natl Acad Sci U S A 2003 Aug 19;100(17):9768-73 -
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP
Proc Natl Acad Sci U S A 2003 Jul 22;100(15):8660-5 -
Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1
J Biol Chem 2002 Nov 29;277(48):45759-64 -
The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase
J Biol Chem 2002 Nov 15;277(46):43836-43 -
The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase
J Biol Chem 2002 Aug 30;277(35):31857-62 -
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death
J Biol Chem 2002 Feb 22;277(8):6266-72 -
Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity
Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9499-504 -
Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2
J Biol Chem 2001 Nov 2;276(44):40998-1004 -
Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export
Proc Natl Acad Sci U S A 2001 Jan 30;98(3):875-9 -
Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1
Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13696-701 -
An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity
Mol Biochem Parasitol 2000 Apr 30;108(1):119-23 -
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase
J Biol Chem 2000 Jun 30;275(26):20110-6 -
The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity
Mol Cell 2000 Jan;5(1):1-11 -
Increased levels of plasma lysosomal enzymes in patients with Lowe syndrome
Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13342-4 -
The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3640-5 -
The role of phosphatases in inositol signaling reactions
J Biol Chem 1999 Apr 16;274(16):10669-72 -
Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation
Blood 1998 Aug 15;92(4):1199-205 -
SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase [see comments]
Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14057-9 -
The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages
Curr Biol 1998 Sep 10;8(18):1035-8 -
Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate
J Biol Chem 1998 Jan 16;273(3):1574-82 -
Phosphatidylinositol signalling reactions
Semin Cell Dev Biol 1998 Apr;9(2):153-60 -
Prostaglandins: critical roles in pregnancy and colon cancer
Curr Biol 1998 Jan 29;8(3):R87-9 -
The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation
Leukemia 1997 Apr;11 Suppl 3:423-5 -
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family
J Biol Chem 1997 Sep 19;272(38):23859-64 -
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
J Biol Chem 1997 Jul 11;272(28):17756-61 -
Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets
J Biol Chem 1997 Apr 25;272(17):10987-9 -
Characterization of a cDNA encoding Arabidopsis thaliana inositol 1,3,4- trisphosphate 5/6-kinase
Biochem Biophys Res Commun 1997 Mar 27;232(3):678-81 -
Signaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association
J Biol Chem 1997 Feb 28;272(9):5983-8 -
Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I
J Biol Chem 1997 Jan 17;272(3):1786-90 -
A novel phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase associates with the interleukin-3 receptor
J Biol Chem 1996 Nov 22;271(47):29729-33 -
The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation
J Biol Chem 1996 Nov 15;271(46):29271-8 -
Inositols do it all
Genes Dev 1996 May 1;10(9):1051-3 -
The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells
Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12980-5 -
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme
J Biol Chem 1996 May 17;271(20):11904-10 -
The properties of the protein tyrosine phosphatase PTPMEG
J Biol Chem 1996 Nov 1;271(44):27751-9 -
Mutation of the conserved domains of two inositol polyphosphate 5- phosphatases
Biochemistry 1996 Jun 18;35(24):7890-4 -
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5- triphosphate 5-phosphatase
Proc Natl Acad Sci U S A 1996 Feb 20;93(4):1689-93 -
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
Curr Biol 1996 Apr 1;6(4):438-45 -
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase
J Biol Chem 1995 Jul 7;270(27):16128-33 -
The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5- bisphosphate 5-phosphatase
Proc Natl Acad Sci U S A 1995 May 23;92(11):4853-6 -
Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure
Proc Natl Acad Sci U S A 1995 May 23;92(11):5149-53 -
Properties of type II inositol polyphosphate 5-phosphatase
J Biol Chem 1995 Apr 21;270(16):9370-7 -
Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP- 3/AP180) and inhibits clathrin cage assembly in vitro
J Biol Chem 1995 Jan 6;270(1):214-7 -
Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution
Biochemistry 1994 Nov 15;33(45):13164-71 -
Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis
J Biol Chem 1994 Aug 5;269(31):19992-9 -
Human genetics. Bad blood by mutation
Nature 1994 May 5;369(6475):14-5 -
Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography
J Biol Chem 1994 Mar 25;269(12):8716-20 -
Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells. [published erratum appears in J Biol Chem 1994 Dec 9;269(49):31322]
J Biol Chem 1994 Mar 18;269(11):7847-50 -
Crystallization and initial X-ray crystallographic characterization of recombinant bovine inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells
J Mol Biol 1994 Feb 18;236(2):584-9 -
Platelets
In: G. Stamatoyannopoulos, A.W. Nienhuis, P.W. Majerus and H. Varmus (Eds.), Molecular Basis of Blood Diseases, 2nd ed. Philadelphia: W.B. Saunders Company (1994) -
Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase
Proc Natl Acad Sci U S A 1993 Jun 15;90(12):5833-7 -
Inherited predisposition to thrombosis
Cell 1993 Feb 26;72(4):477-80 -
Mammalian cells that express Bacillus cereus phosphatidylinositol-specific phospholipase C have increased levels of inositol cyclic 1:2-phosphate, inositol 1-phosphate, and inositol 2-phosphate
J Biol Chem 1992 Oct 5;267(28):19919-23 -
Identification of a phosphodiesterase that converts inositol cyclic 1:2- phosphate to inositol 2-phosphate
J Biol Chem 1992 Oct 5;267(28):19924-8 -
Cloning and expression of a cytosolic megakaryocyte protein-tyrosine- phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p
Proc Natl Acad Sci U S A 1992 Apr 1;89(7):2980-4 -
Inositol phosphate biochemistry
Annu Rev Biochem 1992;61:225-50 -
The George M. Kober Lecture: molecular mechanisms of intracellular signal transduction
Trans Assoc Am Physicians 1991;104:clxviii-clxxx -
The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular transformation
J Biol Chem 1992 Feb 15;267(5):3289-93 -
Diverse proteins homologous to inositol monophosphatase
FEBS Lett 1991 Dec 2;294(1-2):16-8 -
Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate
Proc Natl Acad Sci U S A 1991 Oct 15;88(20):9184-7 -
Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase
J Biol Chem 1991 Oct 25;266(30):20283-9 -
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate
J Biol Chem 1991 Sep 25;266(27):18378-86 -
Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1
Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5867-71 -
Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts
Biochem Biophys Res Commun 1991 Mar 15;175(2):568-76 -
Cyclic hydrolase-transfected 3T3 cells have low levels of inositol 1,2- cyclic phosphate and reach confluence at low density
J Biol Chem 1991 May 15;266(14):9086-92 -
Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate
J Biol Chem 1991 Jan 15;266(2):851-6 -
Anticoagulant, thrombolytic and antiplatelet drugs
The pharmacologic basis of theropeutics. A. Gilman, ed., pp. 1311-1331. New York: Pergamon Press (1990) -
The phosphatidylinositol pathway of platelets and vascular cells
Ann N Y Acad Sci 1991;614:44-50 -
Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase
Proc Natl Acad Sci U S A 1990 Dec;87(24):9548-52 -
Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets
Proc Natl Acad Sci U S A 1990 Dec;87(23):9396-400 -
Recent insights in phosphatidylinositol signaling
Cell 1990 Nov 2;63(3):459-65 -
Phosphatidylinositol-derived precursors and signals
Annu Rev Cell Biol 1990;6:41-67 -
Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III
Science 1990 May 4;248(4955):605-7 -
Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets
J Biol Chem 1990 Dec 15;265(35):21676-83 -
The isolation and characterization of inositol polyphosphate 4-phosphatase
J Biol Chem 1990 Jan 25;265(3):1806-11 -
Structure and function of thrombomodulin: a natural anticoagulant
Blood 1990 Jan 15;75(2):329-36 -
Phosphatidylinositol phospholipase C
In: L. Birnbaumer and R. Iyengar (eds.), G-Proteins. Academic Press, 429-452 (1990) -
Inherited disorders of platelets
In: R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle (eds.), The Metabolic Basis of Inherited Disease, 6th edition. New York: McGraw Hill (1989) -
The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells
J Biol Chem 1989 Nov 25;264(33):19911-5 -
Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin
Proc Natl Acad Sci U S A 1989 Sep;86(18):7179-82 -
Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II
J Biol Chem 1989 May 25;264(15):8759-63 -
Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets
J Biol Chem 1989 May 25;264(15):8873-7 -
Sequence of a cDNA for mouse thrombomodulin and comparison of the predicted mouse and human amino acid sequences
Nucleic Acids Res 1989 Jan 25;17(2):802 -
[Distribution of thrombomodulin in human tissues and characterization of thrombomodulin in plasma]
Nippon Ketsueki Gakkai Zasshi 1988 Nov;51(7):1228-33 -
The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells
J Biol Chem 1988 Oct 25;263(30):15815-22 -
Properties of inositol polyphosphate 1-phosphatase
J Biol Chem 1988 Oct 5;263(28):14559-65 -
Inositol phosphates: synthesis and degradation
J Biol Chem 1988 Mar 5;263(7):3051-4 -
A role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in mice
Blood 1988 Mar;71(3):728-33 -
Isolation of 1-monomethylphosphoinositol 4,5-bisphosphate [a product of methanolysis of inositol 1,2-(cyclic)-4,5-trisphosphate] from Swiss mouse 3T3 cells
Proc Natl Acad Sci U S A 1988 Jan;85(1):88-92 -
The metabolism of inositol phosphates
Cellular and Molecular Aspects of Inflammation, pp. 445-459. Philadelphia: Smith Kline and French Laboratories Research Symposium (1988) -
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+
J Biol Chem 1987 Nov 25;262(33):15946-52 -
Thrombomodulin as a marker for vascular tumors. Comparative study with factor VIII and Ulex europaeus I lectin
Am J Clin Pathol 1987 Oct;88(4):405-11 -
Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene
Biochemistry 1987 Jul 14;26(14):4350-7 -
The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate
J Biol Chem 1987 Jul 15;262(20):9444-7 -
Platelets: Disorders and role in hemostasis
In: P. Leder, PW Majerus, A.W. Nienhuis, G. Stamatoyannopoulos (eds.), Molecular Basis of Blood Diseases, pp. 689-721. Philadelphia: W.B. Saunders Company (1987) -
Eicosadiynoic acid: a non-toxic inhibitor of multiple enzymatic steps in the production of icosanoids from arachidonic acid
Prostaglandins 1987 Apr;33(4):603-15 -
Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism
Proc Natl Acad Sci U S A 1987 Apr;84(8):2170-4 -
Synthesis of inositol 1,2-(cyclic)-4,5-trisphosphate
Proc Natl Acad Sci U S A 1987 Mar;84(5):1206-9 -
Measurement of icosanoid precursor uptake and release by intact cells
Methods Enzymol 1987;141:350-5 -
Phosphoinositide turnover provides a link in stimulus-response coupling
In: R. Bradshaw & S. Prentis (eds.), Oncogenes and Growth Factors, pp. 269-274. Cambridge, U.K.: Elsevier Publications (1987) -
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes
J Biol Chem 1987 Feb 15;262(5):2146-9 -
Protein C inhibits endocytosis of thrombin-thrombomodulin complexes in A549 lung cancer cells and human umbilical vein endothelial cells
Blood 1987 May;69(5):1481-4 -
Phosphoinositide metabolism in human platelets
Adv Prostaglandin Thromboxane Leukot Res 1987;17A:558-62 -
Complex interaction between factor Va-light chain and thrombomodulin in the regulation of protein C activation
Ann N Y Acad Sci 1986;485:221-7 -
The metabolism of phosphoinositide-derived messenger molecules
Science 1986 Dec 19;234(4783):1519-26 -
Guanine nucleotides stimulate soluble phosphoinositide-specific phospholipase C in the absence of membranes
J Biol Chem 1986 Dec 15;261(35):16553-8 -
Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity
Cell 1986 Sep 12;46(6):951-8 -
Inositol cyclic triphosphate [inositol 1,2-(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets
Proc Natl Acad Sci U S A 1986 Sep;83(17):6397-401 -
Isolation of D-myo-inositol 1:2-cyclic phosphate 2-inositolphosphohydrolase from human placenta
J Biol Chem 1986 Aug 25;261(24):11119-23 -
Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain
Blood 1986 Feb;67(2):362-5 -
Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts
J Biol Chem 1986 Jan 5;261(1):122-6 -
The production of phosphoinositide-derived messenger molecules
Harvey Lect 1986-87;82:145-55 -
The role of phosphoinositides in cell physiology
Symp Fundam Cancer Res 1986;39:157-63 -
Thrombomodulin is present in human plasma and urine
J Clin Invest 1985 Dec;76(6):2178-81 -
The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 lung cancer cells. Endocytosis and degradation of thrombin
J Biol Chem 1985 Dec 15;260(29):15432-8 -
Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells
J Biol Chem 1985 Nov 5;260(25):13496-501 -
Arachidonoyl-CoA synthetase. Separation from nonspecific acyl-CoA synthetase and distribution in various cells and tissues
J Biol Chem 1985 Sep 15;260(20):11016-20 -
The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells
Biochem Biophys Res Commun 1985 Aug 15;130(3):1139-46 -
Uptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography
J Cell Biol 1985 Aug;101(2):573-81 -
Phosphoinositide turnover provides a link in stimulus-response coupling
Trends Biochem Sci 1985;10:168-171 -
Pathways of phosphoinositide metabolism in human platelets
Adv Prostaglandin Thromboxane Leukot Res 1985;15:109-12 -
Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes
Proc Natl Acad Sci U S A 1985 Jun;82(12):4013-7 -
Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate
J Biol Chem 1985 Jul 5;260(13):7868-74 -
Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta
J Cell Biol 1985 Aug;101(2):363-71 -
Phosphoinositide interconversion in thrombin-stimulated human platelets
J Biol Chem 1985 Jan 25;260(2):1046-51 -
Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin
J Clin Invest 1985 Mar;75(3):987-91 -
Mechanisms for eicosanoid precursor uptake and release by a tissue culture cell line
In: J.E. Bleasdale, Eichberg, J., and G. Hauser (eds.), Inositol and Phosphoinositides: Metabolism and Regulation, pp. 443-457. Clifton, NJ: Humana Press (1985) -
Production of phosphoinositide-derived messengers
Cell 1984 Jul;37(3):701-3 -
Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes
J Biol Chem 1984 Oct 10;259(19):11718-24 -
Isolation and characterization of thrombomodulin from human placenta
J Biol Chem 1984 Oct 10;259(19):12246-51 -
Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation
J Clin Invest 1984 Jul;74(1):224-30 -
Effects of thrombomodulin and coagulation Factor Va-light chain on protein C activation in vitro
J Clin Invest 1984 Apr;73(4):968-72 -
Fatty acid structural requirements for activity of arachidonoyl-CoA synthetase
J Lipid Res 1984 Mar;25(3):288-93 -
A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase
J Biol Chem 1984 Feb 10;259(3):1986-92 -
Biosynthesis of coagulation Factor V by a human hepatocellular carcinoma cell line
J Clin Invest 1984 Mar;73(3):654-8 -
Arachidonate metabolism in vascular disorders
J Clin Invest 1983 Nov;72(5):1521-5 -
RHC 80267 does not inhibit the diglyceride lipase pathway in intact platelets
Biochem Biophys Res Commun 1983 Oct 14;116(1):68-74 -
Antithrombotic therapy: Current achievements and future directions
Drug Therapy 1983;13:51-52 -
The light chain of factor Va contains the activity of factor Va that accelerates protein C activation by thrombin
J Biol Chem 1983 Jul 25;258(14):8531-4 -
High affinity esterification of eicosanoid precursor fatty acids by platelets
J Clin Invest 1983 Jul;72(1):214-20 -
Human coagulation factor Va is a cofactor for the activation of protein C
Proc Natl Acad Sci U S A 1983 Mar;80(6):1584-8 -
Arachidonate release and phosphatidic acid turnover in stimulated human platelets
J Biol Chem 1983 Feb 25;258(4):2461-7 -
Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate
J Biol Chem 1983 Jan 25;258(2):764-9 -
Uptake and release of arachidonate by platelets
Adv Prostaglandin Thromboxane Leukot Res 1983;11:45-52 -
Drugs for the prevention of cardiovascular disease
In: Kaplan (ed.), Preventive Cardiology, pp. 147-160. Philadelphia: W.B. Saunders (1983) -
Development and characterization of a tissue culture cell line with essential fatty acid deficiency
Proc Natl Acad Sci U S A 1982 Dec;79(24):7654-8 -
Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions
J Biol Chem 1982 Dec 10;257(23):14359-64 -
Activation of coagulation factor V by a platelet protease
J Clin Invest 1982 Nov;70(5):1092-100 -
Fraud in medical research. Presidential address delivered before the 74th annual meeting of the American Society for Clinical Investigation, Washington, DC, 8 May 1982
J Clin Invest 1982 Jul;70(1):213-7 -
Identification and properties of two distinct phosphatidylinositol- specific phospholipase C enzymes from sheep seminal vesicular glands
J Biol Chem 1982 Jun 10;257(11):6461-9 -
Discovery of an arachidonoyl coenzyme A synthetase in human platelets
J Biol Chem 1982 Apr 10;257(7):3510-5 -
The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets
Arch Biochem Biophys 1982 Apr 15;215(1):237-44 -
Characterization and assay of diacylglycerol lipase from human platelets
Methods Enzymol 1982;86:11-7 -
Platelet and vascular effects of aspirin
Primary Cardiology 1982;8:58-65 -
Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human platelets
Blood 1982 Jan;59(1):80-5 -
Inherited disorders of platelets
In: Stanbury (ed.), Metabolic Basis of Inherited Disease, 5th edition, pp. 1561-1572. New York: McGraw-Hill(1982) -
The interaction of human coagulation factor Va with platelets
J Biol Chem 1982 Apr 10;257(7):3963-9 -
Purification of human coagulation factors II, IX and X using sulfated dextran beads
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Purification and characterization of human coagulation factor V
J Biol Chem 1981 Jan 25;256(2):1002-7 -
The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets
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Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody
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Prostaglandins 1980 Aug;20(2):269-74 -
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Anal Biochem 1980 Jul 1;105(2):304-10 -
Thrombin-induced hydrolysis of phosphatidylinositol in human platelets
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Purification and properties of human coagulation factor VII
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Factor Va-dependent binding of factor Xa to human platelets
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Plasma antithrombins and thrombin binding to platelets in plasma
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Blood 1979 Nov;54(5):1015-22 -
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The mechanism of action of antiplatelet drugs
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Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin
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Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets
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Acetylation of prostaglandin synthetase by aspirin. Purification and properties of the acetylated protein from sheep vesicular gland
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Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin
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Comparative effects of aspirin and diflunisal on prostaglandin synthetase from human platelets and sheep seminal vesicles
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Lack of covalent modification of prostaglandin synthetase (cyclo- oxygenase) by indomethacin
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Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions
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The measurement of thrombin in clotting blood by radioimmunoassay
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The binding of human and bovine thrombin to human platelets
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Binding of the products of prothrombin activation to human platelets
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The perturbation of thrombin binding to human platelets by anions
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Acetylation of prostaglandin synthase by aspirin
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Thrombin-induced protein phosphorylation in human platelets
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Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments
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Isolation of human platelets and platelet surface membranes
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Erythrocyte glutathione synthesis in the neonate
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The binding of thrombin to the surface of human platelets
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The effects of thrombin on phytohemagglutinin receptor sites in human platelets
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Induction of the platelet release reaction by phytohemagglutinin
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The regulation of fatty acid synthesis in human skin fibroblasts. Inhibition of fatty acid synthesis by free fatty acids
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The regulation of fatty acid biosynthesis in human skin fibroblasts
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Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma
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Isolation of vitamin B12-binding proteins using affinity chromatography. 3. Purification and properties of human plasma transcobalamin II
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Isolation of vitamin B12-binding proteins using affinity chromatography. II. Purification and properties of a human granulocyte vitamine B12-binding protein
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Isolation of vitamin B12-binding proteins using affinity chromatography. I. Preparation and properties of vitamin B12-sepharose
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The binding of phytohemagglutinins to human platelet plasma membranes
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The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets
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Acetyl coenzyme A carboxylase. The effects of biotin deficiency on enzyme in rat liver and adipose tissue
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Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver
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Lipid metabolism in human platelets. I. Evidence for a complete fatty acid synthesizing system
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Beta-ketoacyl acyl carrier protein reductase
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Beta-hydroxyacyl ACP dehydrase from Escherichia coli
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Beta-ketoacyl acyl carrier protein synthetase
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Acetyl CoA-acyl carrier protein transacylase
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Malonyl CoA-acyl carrier protein transacylase
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Acyl carrier protein from Escherichia coli
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Mechanism of saturated fatty acid biosynthesis in Escherichia coli
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The regulation of fatty acid biosynthesis in rat hepatomas
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Acyl carrier proteIn: effects of acetylation and tryptic hydrolysis on function in fatty acid synthesis
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The preparation of the acyl carrier protein from Escherichia coli
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Fatty acid biosynthesis in human leukocytes
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Fatty acid biosynthesis and the role of the acyl carrier protein
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Structure and function of the acyl carrier protein
Fed Proc 1966 Sep-Oct;25(5):1485-94 -
The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. V. The role of acyl carrier protein
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The mechanism of fatty acid biosynthesis and the involvement of an acyl carrier protein
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Biochemistry 1965;4:2265-2274 -
Acyl carrier protein. IV. The identification of 4'-phosphopantetheine as the prosthetic group of the acyl carrier protein
Proc Natl Acad Sci U S A 1965 Feb;53:410-7 -
Acyl carrier protein. III. An enoyl-hydrase specific for acyl carrier protein thioesters
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Biochemistry 1964 Oct;3:1563-71 -
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Proc Natl Acad Sci U S A 1964 Jun;51:1231-8 -
Psychologic factors and psychiatric disease in hyperemesis gravidarum: A followup study of 69 vomiters and 66 controls
Am J Psychiatry 1960 Nov;117:421-8 -
Association of clinical psychiatric disease with hyperemesis gravidarum. A three-and-a-half-year follow-up study of 48 patients and 45 controls
N Engl J Med 1959 Dec 31;261:1363-8
