Faculty
Oncology Division
Alphabetical list (active faculty):   
Lee Ratner

Lee Ratner, MD, PhD

Alan A. and Edith L. Wolff Professor of Oncology


Professor

Department of Medicine

Oncology Division

Molecular Oncology

Department of Molecular Microbiology

Department of Pathology & Immunology

Clinical Interests

  • AIDS
  • Oncology

Research Interests

  • Human retrovirology (HIV and HTLV)

Contact

Original Research Articles

  • Adult T-Cell Leukemia-Lymphoma Presenting Concurrently With Myelopathy
    Poondru S, Joseph A, Harding JC, Sundaramoorthi H, Mehta-Shah N, Green P, Hassan A, Rauch DA, Ratner L
    Case Rep Oncol 2022 Nov 8;15(3):918-926
  • Defactinib, Pembrolizumab, and Gemcitabine in Patients With Advanced Treatment Refractory Pancreatic Cancer: A Phase I Dose Escalation and Expansion Study
    Wang-Gillam A, Lim KH, McWilliams R, Suresh R, Lockhart AC, Brown A, Breden M, Belle JI, Herndon J, Bogner SJ, Pedersen K, Tan B, Boice N, Acharya A, Abdiannia M, Gao F, Yoon HH, Zhu M, Trikalinos NA, Ratner L, Aranha O, Hawkins WG, Herzog BH, DeNardo DG
    Clin Cancer Res 2022 Dec 15;28(24):5254-5262
  • Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma
    Thomas N, Dreval K, Gerhard DS, Hilton LK, Abramson JS, Barta SK, Bartlett NL, Bethony J, Bhatia K, Bowen J, Bryan AC, Cesarman E, Casper C, Cruz M, Dyer M, Farinha P, Gastier-Foster J, Gerrie AS, Grande B, Greiner TC, Griner N, Gross TG, Harris NL, Irvin JD, Jaffe ES, Henry D, Huppi RL, Leal FE, Lee M, Martin JP, Martin MR, Mbulaiteye SM, Mitsuyasu R, Morris V, Mullighan CG, Mungall AJ, Mungall K, Mutyaba I, Nokta M, Namirembe C, Noy A, Ogwang MD, Omoding A, Orem J, Ott G, Petrello H, Pittaluga S, Phelan JD, Ramos JC, Ratner L, Reynolds SJ, Rubinstein PG, Sissolak G, Slack GW, Soudi S, Swerdlow SH, Traverse-Glehen A, Wilson W, Wong JCH, Yarchoan R, ZenKlusen JC, Marra MA, Staudt LM, Scott DW, Morin RD
    Blood 2022 Oct 6:blood2022016534; [ahead of print]
  • A Role for an HTLV-1 Vaccine?
    Ratner L
    Front Immunol 2022 Sep 8;13:953650
  • Evolution of Multiple Domains of the HIV-1 Envelope Glycoprotein During Coreceptor Switch With CCR5 Antagonist Therapy
    Du Y, Wu E, Gao X, Zhang J, Martin JC, Rosa BA, Mitreva M, Ratner L
    Microbiol Spectr 2022 Aug 31;10(4):e0072522
  • Safety and Tolerability of Carboplatin and Paclitaxel in Cancer Patients With HIV (AMC-078), an AIDS Malignancy Consortium (AMC) Study
    Haigentz M, Moore P, Bimali M, Cooley T, Sparano J, Rudek M, Ratner L, Henry D, Ramos J, Deeken J, Rubinstein P, Chiao E
    Oncologist 2022 Aug 5;27(8):623-e624
  • Phase 1b Trial of Anti-VEGF/PDGFR Vorolanib Combined With Immune Checkpoint Inhibitors in Patients With Advanced Solid Tumors
    Bagegni NA, Park H, Kraft K, O-Toole M, Gao F, Waqar SN, Ratner L, Morgensztern D, Devarakonda S, Amin M, Baggstrom MQ, Liang C, Selvaggi G, Wang-Gillam A
    Cancer Chemother Pharmacol 2022 Apr;89(4):487-497
  • Heparanase Blockade as a Novel Dual-Targeting Therapy for COVID-19
    Xiang J, Lu M, Shi M, Cheng X, Kwakwa KA, Davis JL, Su X, Bakewell SJ, Zhang Y, Fontana F, Xu Y, Veis DJ, DiPersio JF, Ratner L, Sanderson RD, Noseda A, Mollah S, Li J, Weilbaecher KN
    J Virol 2022 Apr 13;96(7):e0005722
  • Targeting NF-KappaB With Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma
    Rauch DA, Harding JC, Ratner L, Wickline SA, Pan H
    Nanomaterials (Basel) 2021 Jun 16;11(6)
  • Epigenomic Regulation of Human T-Cell Leukemia Virus by Chromatin-Insulator CTCF
    Cheng X, Joseph A, Castro V, Chen-Liaw A, Skidmore Z, Ueno T, Fujisawa JI, Rauch DA, Challen GA, Martinez MP, Green P, Griffith M, Payton JE, Edwards JR, Ratner L
    PLoS Pathog 2021 May 21;17(5):e1009577
  • Germinal Epimutation of Fragile Histidine Triad (FHIT) Gene Is Associated With Progression to Acute and Chronic Adult T-Cell Leukemia Diseases
    Bellon M, Bialuk I, Galli V, Bai XT, Farre L, Bittencourt A, Marcais A, Petrus MN, Ratner L, Waldmann TA, Asnafi V, Gessain A, Matsuoka M, Franchini G, Hermine O, Watanabe T, Nicot C
    Mol Cancer 2021 Jun 6;20(1):86
  • Response-Adapted Therapy With Infusional EPOCH Chemotherapy Plus Rituximab in HIV-Associated, B-Cell Non-Hodgkin's Lymphoma
    Sparano JA, Lee JY, Kaplan LD, Ramos JC, Ambinder RF, Wachsman W, Aboulafia D, Noy A, Henry DH, Ratner L, Cesarman E, Chadburn A, Mitsuyasu R
    Haematologica 2021 Mar 1;106(3):730-735
  • Interferon Regulatory Factor 4 as a Therapeutic Target in Adult T-Cell Leukemia Lymphoma
    Rauch DA, Olson SL, Harding JC, Sundaramoorthi H, Kim Y, Zhou T, MacLeod AR, Challen G, Ratner L
    Retrovirology 2020 Aug 28;17(1):27
  • Impact of Myc in HIV-Associated Non-Hodgkin Lymphomas Treated With EPOCH and Outcomes With Vorinostat (AMC-075 Trial)
    Ramos JC, Sparano JA, Chadburn A, Reid EG, Ambinder RF, Siegel ER, Moore PC, Rubinstein PG, Durand CM, Cesarman E, Aboulafia D, Baiocchi R, Ratner L, Kaplan L, Capoferri AA, Lee JY, Mitsuyasu R, Noy A
    Blood 2020 Sep 10;136(11):1284-1297
  • The Dual-Specificity Kinase DYRK1A Modulates the Levels of Cyclin L2 to Control HIV Replication in Macrophages
    Kisaka JK, Ratner L, Kyei GB
    J Virol 2020 Feb 28;94(6)
  • HTLV-1 CTCF-Binding Site Is Dispensable for in Vitro Immortalization and Persistent Infection in Vivo
    Martinez MP, Cheng X, Joseph A, Al-Saleem J, Panfil AR, Palettas M, Dirksen WP, Ratner L, Green PL
    Retrovirology 2019 Dec 21;16(1):44
  • Rapid Progression of Adult T-Cell Leukemia/Lymphoma as Tumor-Infiltrating Tregs After PD-1 Blockade
    Rauch DA, Conlon KC, Janakiram M, Brammer JE, Harding JC, Ye BH, Zang X, Ren X, Olson S, Cheng X, Miljkovic MD, Sundaramoorthi H, Joseph A, Skidmore ZL, Griffith OL, Griffith M, Waldmann TA, Ratner L
    Blood 2019 Oct 24;134(17):1406-1414
  • HTLV-1 Tax-1 Interacts With SNX27 to Regulate Cellular Localization of the HTLV-1 Receptor Molecule, GLUT1
    Al-Saleem J, Dirksen WP, Martinez MP, Shkriabai N, Kvaratskhelia M, Ratner L, Green PL
    PLoS One 2019 Mar 21;14(3):e0214059
  • HTLV-1 Viral Oncogene HBZ Drives Bone Destruction in Adult T Cell Leukemia
    Xiang J, Rauch DA, Huey DD, Panfil AR, Cheng X, Esser AK, Su X, Harding JC, Xu Y, Fox GC, Fontana F, Kobayashi T, Su J, Sundaramoorthi H, Wong WH, Jia Y, Rosol TJ, Veis DJ, Green PL, Niewiesk S, Ratner L, Weilbaecher KN
    JCI Insight 2019 Oct 3;4(19)
  • V1 and V2 Domains of HIV Envelope Contribute to CCR5 Antagonist Resistance
    Wu E, Du Y, Gao X, Zhang J, Martin J, Mitreva M, Ratner L
    J Virol 2019 Apr 17;93(9)
  • The Human T-Cell Leukemia Virus Type-1 Tax Oncoprotein Dissociates NF-KappaB P65(RelA)-Stathmin Complexes and Causes Catastrophic Mitotic Spindle Damage and Genomic Instability
    Malu A, Hutchison T, Yapindi L, Smith K, Nelson K, Bergeson R, Pope J, Romeo M, Harrod C, Ratner L, Van Lint C, Harrod R
    Virology 2019 Sep;535:83-101
  • Dynamic Host Immune Response in Virus-Associated Cancers
    Cao S, Wylie KM, Wyczalkowski MA, Karpova A, Ley J, Sun S, Mashl RJ, Liang WW, Wang X, Johnson K, DiPersio JF, Gay H, Ratner L, Chen F, Adkins DR, Ding L
    Commun Biol 2019 Mar 22;2(1):109
  • North American ATLL Has a Distinct Mutational and Transcriptional Profile and Responds to Epigenetic Therapies
    Shah UA, Chung EY, Giricz O, Pradhan K, Kataoka K, Gordon-Mitchell S, Bhagat TD, Mai Y, Wei Y, Ishida E, Choudhary GS, Joseph A, Rice R, Gitego N, Parrish C, Bartenstein M, Goel S, Mantzaris I, Shastri A, Derman O, Binder A, Gritsman K, Kornblum N, Braunschweig I, Bhagat C, Hall J, Graber A, Ratner L, Wang Y, Ogawa S, Verma A, Ye BH, Janakiram M
    Blood 2018 Oct 4;132(14):1507-1518
  • The TP53-Induced Glycolysis and Apoptosis Regulator Mediates Cooperation Between HTLV-1 p30(II) and the Retroviral Oncoproteins Tax and HBZ and Is Highly Expressed in an in Vivo Xenograft Model of HTLV-1-Induced Lymphoma
    Hutchison T, Malu A, Yapindi L, Bergeson R, Peck K, Romeo M, Harrod C, Pope J, Smitherman L, Gwinn W, Ratner L, Yates C, Harrod R
    Virology 2018 Jul;520:39-58
  • Rapid Progression of Adult T-Cell Leukemia-Lymphoma After PD-1 Inhibitor Therapy
    Ratner L, Waldmann TA, Janakiram M, Brammer JE
    N Engl J Med 2018 May 17;378(20):1947-1948
  • An Activating Mutation of Interferon Regulatory Factor 4 (IRF4) in Adult T-Cell Leukemia
    Cherian MA, Olson S, Sundaramoorthi H, Cates K, Cheng X, Harding J, Martens A, Challen GA, Tyagi M, Ratner L, Rauch D
    J Biol Chem 2018 May 4;293(18):6844-6858
  • PDZ Domain-Binding Motif of Tax Sustains T-Cell Proliferation in HTLV-1-Infected Humanized Mice
    Peres E, Blin J, Ricci EP, Artesi M, Hahaut V, Van den Broeke A, Corbin A, Gazzolo L, Ratner L, Jalinot P, Duc Dodon M
    PLoS Pathog 2018 Mar 22;14(3):e1006933
  • Safety and Preliminary Efficacy of Vorinostat With R-EPOCH in High-Risk HIV-Associated Non-Hodgkin's Lymphoma (AMC-075)
    Ramos JC, Sparano JA, Rudek MA, Moore PC, Cesarman E, Reid EG, Henry D, Ratner L, Aboulafia D, Lee JY, Ambinder RF, Mitsuyasu R, Noy A
    Clin Lymphoma Myeloma Leuk 2018 Mar;18(3):180-190e2
  • Splicing Factor 3B Subunit 1 Interacts With HIV Tat and Plays a Role in Viral Transcription and Reactivation From Latency
    Kyei GB, Meng S, Ramani R, Niu A, Lagisetti C, Webb TR, Ratner L
    MBio 2018 Nov 6;9(6)
  • The Human T-Cell Leukemia Virus Type-1 p30(II) Protein Activates p53 and Induces the TIGAR and Suppresses Oncogene-Induced Oxidative Stress During Viral Carcinogenesis
    Romeo M, Hutchison T, Malu A, White A, Kim J, Gardner R, Smith K, Nelson K, Bergeson R, McKee R, Harrod C, Ratner L, Luscher B, Martinez E, Harrod R
    Virology 2018 May;518:103-115
  • Brentuximab Vedotin With AVD Shows Safety, in the Absence of Strong CYP3A4 Inhibitors, in Newly Diagnosed HIV-Associated Hodgkin Lymphoma
    Rubinstein PG, Moore PC, Rudek MA, Henry DH, Ramos JC, Ratner L, Reid E, Sharon E, Noy A
    AIDS Malignancy Consortium (AMC)
    AIDS 2018 Mar 13;32(5):605-611
  • Role of Wild-Type and Recombinant Human T-Cell Leukemia Viruses in Lymphoproliferative Disease in Humanized NSG Mice
    Huey DD, Bolon B, La Perle KMD, Kannian P, Jacobson S, Ratner L, Green PL, Niewiesk S
    Comp Med 2018 Feb 1;68(1):4-14
  • HTLV-1 Viral Oncogene HBZ Induces Osteolytic Bone Disease in Transgenic Mice
    Esser AK, Rauch DA, Xiang J, Harding JC, Kohart NA, Ross MH, Su X, Wu K, Huey D, Xu Y, Vij K, Green PL, Rosol TJ, Niewiesk S, Ratner L, Weilbaecher KN
    Oncotarget 2017 Aug 27;8(41):69250-69263
  • Combinations of Isoform-Targeted Histone Deacetylase Inhibitors and Bryostatin Analogues Display Remarkable Potency to Activate Latent HIV Without Global T-Cell Activation
    Albert BJ, Niu A, Ramani R, Marshall GR, Wender PA, Williams RM, Ratner L, Barnes AB, Kyei GB
    Sci Rep 2017 Aug 7;7(1):7456
  • High Frequency of Identical Clonal Immunoglobulin DNA in Pre-Treatment Tumor and Plasma From Untreated Patients With HIV-Associated Lymphoma: Prospective Multicenter Trial of the AIDS Malignancies Consortium (AMC 064)
    Wagner-Johnston ND, Lensing S, Noy A, Ratner L, Henry D, Lee JY, Silver S, Faham M, Ambinder RF
    Leuk Lymphoma 2017 Dec;58(12):2939-2942
  • Cetuximab Plus Chemoradiotherapy for HIV-Associated Anal Carcinoma: A Phase II AIDS Malignancy Consortium Trial
    Sparano JA, Lee JY, Palefsky J, Henry DH, Wachsman W, Rajdev L, Aboulafia D, Ratner L, Fitzgerald TJ, Kachnic L, Mitsuyasu R
    J Clin Oncol 2017 Mar;35(7):727-733
  • Dose-Adjusted EPOCH Chemotherapy With Bortezomib and Raltegravir for Human T-Cell Leukemia Virus-Associated Adult T-Cell Leukemia Lymphoma
    Ratner L, Rauch D, Abel H, Caruso B, Noy A, Barta SK, Parekh S, Ramos JC, Ambinder R, Phillips A, Harding J, Baydoun HH, Cheng X, Jacobson S
    Blood Cancer J 2016 Mar 25;6:e408
  • Evolution of Coreceptor Utilization to Escape CCR5 Antagonist Therapy
    Zhang J, Gao X, Martin J, Rosa B, Chen Z, Mitreva M, Henrich T, Kuritzkes D, Ratner L
    Virology 2016 Jul;494:198-214
  • Novel Interactions Between the HTLV Antisense Proteins HBZ and APH-2 and the NFAR Protein Family: Implications for the HTLV Lifecycles
    Murphy J, Hall WW, Ratner L, Sheehy N
    Virology 2016 Jul;494:129-42
  • Mutation of Epigenetic Regulators TET2 and MLL3 in Patients With HTLV-I-Induced Acute Adult T-Cell Leukemia
    Yeh CH, Bai XT, Moles R, Ratner L, Waldmann TA, Toshiki W, Nicot C
    Mol Cancer 2016 Feb 16;15(1):15
  • Plasmablastic Lymphoma Is Treatable in the HAART Era. A 10 Year Retrospective by the AIDS Malignancy Consortium
    Noy A, Lensing SY, Moore PC, Gupta N, Aboulafia D, Ambinder R, Baiocchi R, Dezube BJ, Henry D, Kaplan L, Levine AM, Mitsuyasu R, Ratner L, Reid E, Remick S, Sparano J, Tzachanis D, Wachsman W, Chadburn A
    Leuk Lymphoma 2016 Jul;57(7):1731-1734
  • Akt Pathway Activation by Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein
    Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
    J Biol Chem 2015 Oct 23;290(43):26270-26281
  • Changes in the Influence of Lymphoma- And HIV-Specific Factors on Outcomes in AIDS-Related Non-Hodgkin Lymphoma
    Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Little RF, Dunleavy K, Wilson WH, Wyen C, Remick SC, Kaplan LD, Ratner L, Noy A, Sparano JA
    Ann Oncol 2015 May;26(5):958-66
  • Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-KappaB Inhibitor A20 and Constitutive NF-KappaB Signaling
    Pujari R, Hunte R, Thomas R, van der Weyden L, Rauch D, Ratner L, Nyborg JK, Ramos JC, Takai Y, Shembade N
    PLoS Pathog 2015 Mar 16;11(3):e1004721
  • Acetylation of the c-MYC Oncoprotein Is Required for Cooperation With the HTLV-1 p30(II) Accessory Protein and the Induction of Oncogenic Cellular Transformation by p30(II)/c-MYC
    Romeo MM, Ko B, Kim J, Brady R, Heatley HC, He J, Harrod CK, Barnett B, Ratner L, Lairmore MD, Martinez E, Luscher B, Robson CN, Henriksson M, Harrod R
    Virology 2015 Feb;476:271-88
  • Inducible Nitric Oxide Synthase Mediates DNA Double Strand Breaks in Human T-Cell Leukemia Virus Type 1-Induced Leukemia/Lymphoma
    Baydoun HH, Cherian MA, Green P, Ratner L
    Retrovirology 2015 Aug 12;12(1):71
  • AMC 048: Modified CODOX-M/IVAC-Rituximab Is Safe and Effective for HIV-Associated Burkitt Lymphoma
    Noy A, Lee JY, Cesarman E, Ambinder R, Baiocchi R, Reid E, Ratner L, Wagner-Johnston N, Kaplan L
    AIDS Malignancy Consortium
    Blood 2015 Jul 9;126(2):160-6
  • Cyclin L2 Is a Critical HIV Dependency Factor in Macrophages That Controls SAMHD1 Abundance
    Kyei GB, Cheng X, Ramani R, Ratner L
    Cell Host Microbe 2015 Jan 14;17(1):98-106
  • HIV-2 Vpx Protein Interacts With Interferon Regulatory Factor 5 (IRF5) and Inhibits Its Function
    Cheng X, Ratner L
    J Biol Chem 2014 Mar 28;289(13):9146-57
  • IL-15 Deficient Tax Mice Reveal a Role for IL-1alpha in Tumor Immunity
    Rauch DA, Harding JC, Ratner L
    PLoS One 2014 Jan 8;9(1):e85028
  • A Phase 1/Pharmacokinetic Study of Sunitinib in Combination With Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus-Positive Patients With Cancer: AIDS Malignancy Consortium Trial AMC 061
    Rudek MA, Moore PC, Mitsuyasu RT, Dezube BJ, Aboulafia D, Gerecitano J, Sullivan R, Cianfrocca ME, Henry DH, Ratner L, Haigentz M, Dowlati A, Little RF, Ivy SP, Deeken JF
    Cancer 2014 Apr 15;120(8):1194-202
  • Mechanisms of Nanoparticle-Mediated siRNA Transfection by Melittin-Derived Peptides
    Hou KK, Pan H, Ratner L, Schlesinger PH, Wickline SA
    ACS Nano 2013 Oct 22;7(10):8605-15
  • Alpha Interferon Restricts Human T-Lymphotropic Virus Type 1 and 2 De Novo Infection Through PKR Activation
    Cachat A, Chevalier SA, Alais S, Ko NL, Ratner L, Journo C, Dutartre H, Mahieux R
    J Virol 2013 Dec;87(24):13386-96
  • Cytolytic Nanoparticles Attenuate HIV-1 Infectivity
    Hood JL, Jallouk AP, Campbell N, Ratner L, Wickline SA
    Antivir Ther 2013;18(1):95-103
  • Pegylated Liposomal Doxorubicin, Rituximab, Cyclophosphamide, Vincristine, and Prednisone in AIDS-Related Lymphoma: AIDS Malignancy Consortium Study 047
    Levine AM, Noy A, Lee JY, Tam W, Ramos JC, Henry DH, Parekh S, Reid EG, Mitsuyasu R, Cooley T, Dezube BJ, Ratner L, Cesarman E, Tulpule A
    J Clin Oncol 2013 Jan 1;31(1):58-64
  • Outcome of Patients With Relapsed/Refractory Acquired Immune Deficiency Syndrome-Related Lymphoma Diagnosed 1999-2008 and Treated With Curative Intent in the AIDS Malignancy Consortium
    Bayraktar UD, Ramos JC, Petrich A, Gupta N, Lensing S, Moore PC, Reid EG, Aboulafia DM, Ratner L, Mitsuyasu R, Cooley T, Henry DH, Barr P, Noy A
    Leuk Lymphoma 2012 Dec;53(12):2383-9
  • Wip1 and p53 Contribute to HTLV-1 Tax-Induced Tumorigenesis
    Zane L, Yasunaga J, Mitagami Y, Yedavalli V, Tang SW, Chen CY, Ratner L, Lu X, Jeang KT
    Retrovirology 2012 Dec 21;9:114
  • HIV-2 Viral Protein X (Vpx) Ubiquitination Is Dispensable for Ubiquitin Ligase Interaction and Effects on Macrophage Infection
    McCulley A, Ratner L
    Virology 2012 May 25;427(1):67-75
  • Vpx Is Critical for SIVmne Infection of Pigtail Macaques
    Belshan M, Kimata JT, Brown C, Cheng X, McCulley A, Larsen A, Thippeshappa R, Hodara V, Giavedoni L, Hirsch V, Ratner L
    Retrovirology 2012 Apr 24;9:32
  • The Smac Mimetic RMT5265.2HCL Induces Apoptosis in EBV and HTLV-I Associated Lymphoma Cells by Inhibiting XIAP and Promoting the Mitochondrial Release of Cytochrome C and Smac
    Ramachandiran S, Cain J, Liao A, He Y, Guo X, Boise LH, Fu H, Ratner L, Khoury HJ, Bernal-Mizrachi L
    Leuk Res 2012 Jun;36(6):784-90
  • Integrase Inhibitors Effective Against Human T-Cell Leukemia Virus Type 1
    Seegulam ME, Ratner L
    Antimicrob Agents Chemother 2011 May;55(5):2011-7
  • Post-Formulation Peptide Drug Loading of Nanostructures for Metered Control of NF-KappaB Signaling
    Pan H, Ivashyna O, Sinha B, Lanza GM, Ratner L, Schlesinger PH, Wickline SA
    Biomaterials 2011 Jan;32(1):231-238
  • The HTLV-1 Hbz Antisense Gene Indirectly Promotes Tax Expression Via Down-Regulation of p30(II) mRNA
    Choudhary G, Ratner L
    Virology 2011 Feb 20;410(2):307-315
  • The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice
    Rauch DA, Hurchla MA, Harding JC, Deng H, Shea LK, Eagleton MC, Niewiesk S, Lairmore MD, Piwnica-Worms D, Rosol TJ, Weber JD, Ratner L, Weilbaecher KN
    PLoS One 2010 Dec 30;5(12):e15755
  • Rituximab Plus Concurrent Infusional EPOCH Chemotherapy Is Highly Effective in HIV-Associated B-Cell Non-Hodgkin Lymphoma
    Sparano JA, Lee JY, Kaplan LD, Levine AM, Ramos JC, Ambinder RF, Wachsman W, Aboulafia D, Noy A, Henry DH, Von Roenn J, Dezube BJ, Remick SC, Shah MH, Leichman L, Ratner L, Cesarman E, Chadburn A, Mitsuyasu R
    Blood 2010 Apr 15;115(15):3008-16
  • Role of Abl Kinase and the Wave2 Signaling Complex in HIV-1 Entry at a Post-Hemifusion Step
    Harmon B, Campbell N, Ratner L
    PLoS Pathog 2010 Jun 17;6(6):e1000956
  • HIV-1 Determinants of Thrombocytopenia at the Stage of CD34+ Progenitor Cell Differentiation in Vivo Lie in the Viral Envelope gp120 V3 Loop Region
    Zhang M, Evans S, Yuan J, Ratner L, Koka PS
    Virology 2010 Jun 5;401(2):131-6
  • Molecular and Clinical Assessment in the Treatment of AIDS Kaposi Sarcoma With Valproic Acid
    Lechowicz M, Dittmer DP, Lee JY, Krown SE, Wachsman W, Aboulafia D, Dezube BJ, Ratner L, Said J, Ambinder RF
    Clin Infect Dis 2009 Dec 15;49(12):1946-1949
  • Suppression of Human T-Cell Leukemia Virus I Gene Expression by Pokeweed Antiviral Protein
    Mansouri S, Choudhary G, Sarzala PM, Ratner L, Hudak KA
    J Biol Chem 2009 Nov 6;284(45):31453-62
  • Acetylation of the Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein by p300 Promotes Activation of the NF-KappaB Pathway
    Lodewick J, Lamsoul I, Polania A, Lebrun S, Burny A, Ratner L, Bex F
    Virology 2009 Mar 30;386(1):68-78
  • T-Cell Activation Promotes Tumorigenesis in Inflammation-Associated Cancer
    Rauch D, Gross S, Harding J, Bokhari S, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L
    Retrovirology 2009 Dec 17;6:116
  • Novel Role for Interleukin-2 Receptor-Jak Signaling in Retrovirus Transmission
    Taylor JM, Brown M, Nejmeddine M, Kim KJ, Ratner L, Lairmore M, Nicot C
    J Virol 2009 Nov;83(22):11467-76
  • Human T Cell Leukemia Virus Reactivation With Progression of Adult T-Cell Leukemia-Lymphoma
    Ratner L, Harrington W, Feng X, Grant C, Jacobson S, Noy A, Sparano J, Lee J, Ambinder R, Campbell N, Lairmore M, For The AIDS Malignancy Consortium
    PLoS ONE 2009;4(2):e4420
  • Mutation of Critical Serine Residues in HIV-1 Matrix Result in an Envelope Incorporation Defect Which Can Be Rescued by Truncation of the gp41 Cytoplasmic Tail
    Bhatia AK, Kaushik R, Campbell NA, Pontow SE, Ratner L
    Virology 2009 Feb 5;384(1):233-41
  • Imaging Spontaneous Tumorigenesis: Inflammation Precedes Development of Peripheral NK Tumors
    Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L
    Blood 2009 Feb 12;113(7):1493-500
  • Bioluminescence Imaging of Myeloperoxidase Activity in Vivo
    Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D
    Nat Med 2009 Apr;15(4):455-61
  • Induction of the Galpha(Q) Signaling Cascade by the Human Immunodeficiency Virus Envelope Is Required for Virus Entry
    Harmon B, Ratner L
    J Virol 2008 Sep;82(18):9191-205
  • Human T-Cell Leukemia Virus Type 1 Blunts Signaling by Interferon Alpha
    Feng X, Ratner L
    Virology 2008 Apr 25;374(1):210-6
  • Hsp40 Facilitates Nuclear Import of the Human Immunodeficiency Virus Type 2 Vpx-Mediated Preintegration Complex
    Cheng X, Belshan M, Ratner L
    J Virol 2008 Feb;82(3):1229-37
  • Modulation of Beta-Catenin and E-Cadherin Interaction by Vpu Increases Human Immunodeficiency Virus Type 1 Particle Release
    Salim A, Ratner L
    J Virol 2008 Apr;82(8):3932-8
  • Effect of Treatment of Strongyloides Infection on HTLV-1 Expression in a Patient With Adult T-Cell Leukemia
    Ratner L, Grant C, Zimmerman B, Fritz J, Weil G, Denes A, Suresh R, Campbell N, Jacobson S, Lairmore M
    Am J Hematol 2007 Oct;82(10):929-31
  • Characterization of Replication Defects Induced by Mutations in the Basic Domain and C-Terminus of HIV-1 Matrix
    Bhatia AK, Campbell N, Panganiban A, Ratner L
    Virology 2007 Dec 5;369(1):47-54
  • Antiviral Activity of a Rac GEF Inhibitor Characterized With a Sensitive HIV/SIV Fusion Assay
    Pontow S, Harmon B, Campbell N, Ratner L
    Virology 2007 Nov 10;368(1):1-6
  • IRF-4 and c-Rel Expression in Antiviral-Resistant Adult T-Cell Leukemia/Lymphoma
    Ramos JC, Ruiz P Jr, Ratner L, Reis IM, Brites C, Pedroso C, Byrne GE Jr, Toomey NL, Andela V, Harhaj EW, Lossos IS, Harrington WJ Jr
    Blood 2007 Apr 1;109(7):3060-8
  • Human T-Lymphotropic Virus Type-1 p30 Alters Cell Cycle G2 Regulation of T Lymphocytes to Enhance Cell Survival
    Datta A, Silverman L, Phipps AJ, Hiraragi H, Ratner L, Lairmore MD
    Retrovirology 2007 Jul 16;4:49
  • Foxp3 Represses Retroviral Transcription by Targeting Both NF-KappaB and CREB Pathways
    Grant C, Oh U, Fugo K, Takenouchi N, Griffith C, Yao K, Newhook TE, Ratner L, Jacobson S
    PLoS Pathog 2006 Apr;2(4):e33
  • Histone Acetyltransferase (HAT) Activity of p300 Modulates Human T Lymphotropic Virus Type 1 p30II-Mediated Repression of LTR Transcriptional Activity
    Michael B, Nair AM, Datta A, Hiraragi H, Ratner L, Lairmore MD
    Virology 2006 Oct 25;354(2):225-39
  • The Role of NF-{kappa}B-1 and NF-{kappa}B-2-Mediated Resistance to Apoptosis in Lymphomas
    Bernal-Mizrachi L, Lovly CM, Ratner L
    Proc Natl Acad Sci U S A 2006 Jun 13;103(24):9220-5
  • Human Immunodeficiency Virus Type 1 Coreceptor Switching: V1/V2 Gain-Of-Fitness Mutations Compensate for V3 Loss-Of-Fitness Mutations
    Pastore C, Nedellec R, Ramos A, Pontow S, Ratner L, Mosier DE
    J Virol 2006 Jan;80(2):750-8
  • Analysis of HIV-2 Vpx by Modeling and Insertional Mutagenesis
    Mahnke LA, Belshan M, Ratner L
    Virology 2006 Apr 25;348(1):165-74
  • Conserved Amino Acids of the Human Immunodeficiency Virus Type 2 Vpx Nuclear Localization Signal Are Critical for Nuclear Targeting of the Viral Preintegration Complex in Non-Dividing Cells
    Belshan M, Mahnke LA, Ratner L
    Virology 2006 Mar 1;346(1):118-26
  • Human T-Lymphotropic Virus Type 1 Mitochondrion-Localizing Protein p13(II) Is Required for Viral Infectivity in Vivo
    Hiraragi H, Kim SJ, Phipps AJ, Silic-Benussi M, Ciminale V, Ratner L, Green PL, Lairmore MD
    J Virol 2006 Apr;80(7):3469-76
  • Antiviral and Immunomodulatory Treatment for AIDS-Related Primary Central Nervous System Lymphoma: AIDS Malignancies Consortium Pilot Study 019
    Aboulafia DM, Ratner L, Miles SA, Harrington WJ Jr
    Clin Lymphoma Myeloma 2006 Mar;6(5):399-402
  • HTLV-1 Tax Transgenic Mice Develop Spontaneous Osteolytic Bone Metastases Prevented by Osteoclast Inhibition
    Gao L, Deng H, Zhao H, Hirbe A, Harding J, Ratner L, Weilbaecher K
    Blood 2005 Dec 15;106(13):4294-302
  • Phase I Study of Pegylated Liposomal Doxorubicin and the Multidrug-Resistance Modulator, Valspodar
    Fracasso PM, Blum KA, Ma MK, Tan BR, Wright LP, Goodner SA, Fears CL, Hou W, Arquette MA, Picus J, Denes A, Mortimer JE, Ratner L, Ivy SP, McLeod HL
    Br J Cancer 2005 Jul 11;93(1):46-53
  • In Vivo Analysis of Replication and Immunogenicity of Proviral Clones of Human T-Lymphotropic Virus Type 1 With Selective Envelope Surface-Unit Mutations
    Silverman LR, Phipps AJ, Montgomery A, Fernandez S, Tsukahara T, Ratner L, Lairmore MD
    Blood 2005 Nov 15;106(10):3602-8
  • Cholesterol Dependence of HTLV-I Infection
    Wielgosz MM, Rauch DA, Jones KS, Ruscetti FW, Ratner L
    AIDS Res Hum Retroviruses 2005 Jan;21(1):43-50
  • Anti-Vpr Activity of a Yeast Chaperone Protein
    Benko Z, Liang D, Agbottah E, Hou J, Chiu K, Yu M, Innis S, Reed P, Kabat W, Elder RT, Di Marzio P, Taricani L, Ratner L, Young PG, Bukrinsky M, Zhao RY
    J Virol 2004 Oct;78(20):11016-29
  • Effects of the Proteasome Inhibitor PS-341 on Tumor Growth in HTLV-1 Tax Transgenic Mice and Tax Tumor Transplants
    Mitra-Kaushik S, Harding JC, Hess JL, Ratner L
    Blood 2004 Aug 1;104(3):802-9
  • Enhanced Tumorigenesis in HTLV-1 Tax-Transgenic Mice Deficient in Interferon-Gamma
    Mitra-Kaushik S, Harding J, Hess J, Schreiber R, Ratner L
    Blood 2004 Nov 15;104(10):3305-11
  • Role of Human Immunodeficiency Virus Type 1 Matrix Phosphorylation in an Early Postentry Step of Virus Replication
    Kaushik R, Ratner L
    J Virol 2004 Mar;78(5):2319-26
  • Human T-Cell Lymphotropic Virus Type 1 Open Reading Frame II-Encoded p30II Is Required for in Vivo Replication: Evidence of in Vivo Reversion
    Silverman LR, Phipps AJ, Montgomery A, Ratner L, Lairmore MD
    J Virol 2004 Apr;78(8):3837-45
  • Substitution of HIV Type 1 Nef With HTLV-1 p12
    Tsukahara T, Ratner L
    AIDS Res Hum Retroviruses 2004 Sep;20(9):938-43
  • Actin Cytoskeletal Reorganizations and Coreceptor-Mediated Activation of Rac During Human Immunodeficiency Virus-Induced Cell Fusion
    Pontow SE, Vander Heyden N, Wei S, Ratner L
    J Virol 2004 Jul;78(13):7138-47
  • Alpha Interferon Inhibits Human T-Cell Leukemia Virus Type 1 Assembly by Preventing Gag Interaction With Rafts
    Feng X, Vander Heyden N, Ratner L
    J Virol 2003 Dec;77(24):13389-95
  • Identification of the Nuclear Localization Signal of Human Immunodeficiency Virus Type 2 Vpx
    Belshan M, Ratner L
    Virology 2003 Jun 20;311(1):7-15
  • Association of Primate T-Cell Lymphotropic Virus Infection of Pig-Tailed Macaques With High Mortality
    McGinn TM, Tao B, Cartner S, Schoeb T, Davis I, Ratner L, Fultz PN
    Virology 2002 Dec 20;304(2):364-78
  • Interaction of HIV-1 Gag and Membranes in a Cell-Free System
    Yang L, Ratner L
    Virology 2002 Oct 10;302(1):164-73
  • Engraftment and Tumorigenesis of HTLV-1 Transformed T Cell Lines in SCID/Bg and NOD/SCID Mice
    Liu Y, Dole K, Stanley JR, Richard V, Rosol TJ, Ratner L, Lairmore M, Feuer G
    Leuk Res 2002 Jun;26(6):561-7
  • Matrix Metalloproteinase Inhibitor COL-3 in the Treatment of AIDS-Related Kaposi's Sarcoma: A Phase I AIDS Malignancy Consortium Study
    Cianfrocca M, Cooley TP, Lee JY, Rudek MA, Scadden DT, Ratner L, Pluda JM, Figg WD, Krown SE, Dezube BJ
    J Clin Oncol 2002 Jan 1;20(1):153-9
  • Tracking the Assembly Pathway of Human Immunodeficiency Virus Type 1 Gag Deletion Mutants by Immunogold Labeling
    Wang JJ, Sandefur S, Spearman P, Chiou CT, Chiang PH, Ratner L
    Appl Immunohistochem Mol Morphol 2001 Dec;9(4):371-9
  • Effects of Mutant Vpr/Vpx on HIV-2 Assembly Demonstrated by Immunoelectron Microscopy
    Wang JJ, Ratner L
    Proc Natl Sci Counc Repub China B 2001 Jan;25(1):50-8
  • Evidence for Common Structural Determinants of Human Immunodeficiency Virus Type 1 Coreceptor Activity Provided Through Functional Analysis of CCR5/CXCR4 Chimeric Coreceptors
    Pontow S, Ratner L
    J Virol 2001 Dec;75(23):11503-14
  • Characterization of Envelope Glycoprotein Mutants for Human T-Cell Leukemia Virus Type 1 Infectivity and Immortalization
    Tsukahara T, Wielgosz MM, Ratner L
    J Virol 2001 Oct;75(19):9553-9
  • Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions With the Coreceptor
    Derdeyn CA, Decker JM, Sfakianos JN, Zhang Z, O'Brien WA, Ratner L, Shaw GM, Hunter E
    J Virol 2001 Sep;75(18):8605-14
  • The Contribution of NF-Kappa B Activity to Spontaneous Proliferation and Resistance to Apoptosis in Human T-Cell Leukemia Virus Type 1 Tax-Induced Tumors
    Portis T, Harding JC, Ratner L
    Blood 2001 Aug 15;98(4):1200-8
  • Chemotherapy for Human Immunodeficiency Virus-Associated Non-Hodgkin's Lymphoma in Combination With Highly Active Antiretroviral Therapy
    Ratner L, Lee J, Tang S, Redden D, Hamzeh F, Herndier B, Scadden D, Kaplan L, Ambinder R, Levine A, Harrington W, Grochow L, Flexner C, Tan B, Straus D
    J Clin Oncol 2001 Apr 15;19(8):2171-8
  • A Novel Inducible Expression System to Study Transdominant Mutants of HIV-1 Vpr
    Zhou Y, Ratner L
    Virology 2001 Aug 15;287(1):133-42
  • Analysis of p53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model
    Portis T, Grossman WJ, Harding JC, Hess JL, Ratner L
    J Virol 2001 Mar;75(5):2185-93
  • Viral Protein U (Vpu)-Mediated Enhancement of Human Immunodeficiency Virus Type 1 Particle Release Depends on the Rate of Cellular Proliferation
    Deora A, Ratner L
    J Virol 2001 Jul;75(14):6714-8
  • Prevalence of HTLV-I-Associated T-Cell Lymphoma
    Poiesz BJ, Papsidero LD, Ehrlich G, Sherman M, Dube S, Poiesz M, Dillon K, Ruscetti FW, Slamon D, Fang C, Williams A, Duggan D, Glaser J, Gottlieb A, Goldberg J, Ratner L, Phillips P, Han T, Friedman-Kien A, Siegal F, Rai K, Sawitsky A, Sheremata LW, Dosik H, Cunningham C, Montagna R
    Am J Hematol 2001 Jan;66(1):32-8
  • HIV Type 2 Vpx Interaction With Gag and Incorporation Into Virus-Like Particles
    Jin L, Zhou Y, Ratner L
    AIDS Res Hum Retroviruses 2001 Jan 20;17(2):105-11
  • Human T-Lymphotropic Virus Type 1 Open Reading Frame I p12(I) Is Required for Efficient Viral Infectivity in Primary Lymphocytes
    Albrecht B, Collins ND, Burniston MT, Nisbet JW, Ratner L, Green PL, Lairmore MD
    J Virol 2000 Nov;74(21):9828-35
  • Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction
    Robek MD, Ratner L
    J Virol 2000 Dec;74(24):11988-92
  • Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120
    Derdeyn CA, Decker JM, Sfakianos JN, Wu X, O'Brien WA, Ratner L, Kappes JC, Shaw GM, Hunter E
    J Virol 2000 Sep;74(18):8358-67
  • Phosphorylation of Human Immunodeficiency Virus Type 1 Vpr Regulates Cell Cycle Arrest
    Zhou Y, Ratner L
    J Virol 2000 Jul;74(14):6520-7
  • Differences Among HIV-1 Variants in Their Ability to Elicit Secretion of TNF-Alpha
    Khanna KV, Yu XF, Ford DH, Ratner L, Hildreth JK, Markham RB
    J Immunol 2000 Feb 1;164(3):1408-15
  • The N-Terminal Matrix Domain of HIV-1 Gag Is Sufficient but Not Necessary for Viral Protein U-Mediated Enhancement of Particle Release Through a Membrane-Targeting Mechanism
    Deora A, Spearman P, Ratner L
    Virology 2000 Apr 10;269(2):305-12
  • Productive Infection of CD34+-Cell-Derived Megakaryocytes by X4 and R5 HIV-1 Isolates
    Voulgaropoulou F, Pontow SE, Ratner L
    Virology 2000 Mar 30;269(1):78-85
  • Functional Role of PX Open Reading Frame II of Human T-Lymphotropic Virus Type 1 in Maintenance of Viral Loads in Vivo
    Bartoe JT, Albrecht B, Collins ND, Robek MD, Ratner L, Green PL, Lairmore MD
    J Virol 2000 Feb;74(3):1094-100
  • Chemotherapy Consisting of Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine With Granulocyte-Colony-Stimulating Factor in HIV-Infected Patients With Newly Diagnosed Hodgkin's Disease: A Prospective, Multi-Institutional AIDS Clinical Trials Group Study (ACTG 149)
    Levine AM, Li P, Cheung T, Tulpule A, Von Roenn J, Nathwani BN, Ratner L
    J Acquir Immune Defic Syndr 2000 Aug 15;24(5):444-50
  • Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain
    Pancio HA, Vander Heyden N, Kosuri K, Cresswell P, Ratner L
    J Virol 2000 Jul;74(13):6168-72
  • The C-Terminal Proline-Rich Tail of Human Immunodeficiency Virus Type 2 Vpx Is Necessary for Nuclear Localization of the Viral Preintegration Complex in Nondividing Cells
    Pancio HA, Vander Heyden N, Ratner L
    J Virol 2000 Jul;74(13):6162-7
  • The HTLV Receptor Is a Widely Expressed Protein
    Trejo SR, Ratner L
    Virology 2000 Mar 1;268(1):41-8
  • Rapid Phenotypic Drug Susceptibility Assay for HIV-1 With a CCR5 Expressing Indicator Cell Line
    Pirounaki M, Heyden NA, Arens M, Ratner L
    J Virol Methods 2000 Mar;85(1-2):151-61
  • Relationship Between Productive HIV-1 Infection of Macrophages and CCR5 Utilization
    Hung CS, Pontow S, Ratner L
    Virology 1999 Nov 25;264(2):278-88
  • Analysis of the Critical Domain in the V3 Loop of Human Immunodeficiency Virus Type 1 gp120 Involved in CCR5 Utilization
    Hung CS, Vander Heyden N, Ratner L
    J Virol 1999 Oct;73(10):8216-26
  • Proliferation Response to Interleukin-2 and Jak/Stat Activation of T Cells Immortalized by Human T-Cell Lymphotropic Virus Type 1 Is Independent of Open Reading Frame I Expression
    Collins ND, D'Souza C, Albrecht B, Robek MD, Ratner L, Ding W, Green PL, Lairmore MD
    J Virol 1999 Nov;73(11):9642-9
  • Immortalization of CD4(+) and CD8(+) T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone
    Robek MD, Ratner L
    J Virol 1999 Jun;73(6):4856-65
  • Distinct Human Immunodeficiency Virus Strains in the Bone Marrow Are Associated With the Development of Thrombocytopenia
    Voulgaropoulou F, Tan B, Soares M, Hahn B, Ratner L
    J Virol 1999 Apr;73(4):3497-504
  • Dysregulated Myelopoiesis in Mice Lacking Jak3
    Grossman WJ, Verbsky JW, Yang L, Berg LJ, Fields LE, Chaplin DD, Ratner L
    Blood 1999 Aug 1;94(3):932-9
  • Killing HIV-Infected Cells by Transduction With an HIV Protease-Activated Caspase-3 Protein
    Vocero-Akbani AM, Heyden NV, Lissy NA, Ratner L, Dowdy SF
    Nat Med 1999 Jan;5(1):29-33
  • Formation and Release of Virus-Like Particles by HIV-1 Matrix Protein
    Wang JJ, Horton R, Varthakavi V, Spearman P, Ratner L
    AIDS 1999 Feb 4;13(2):281-3
  • Particle Size Determinants in the Human Immunodeficiency Virus Type 1 Gag Protein
    Garnier L, Ratner L, Rovinski B, Cao SX, Wills JW
    J Virol 1998 Jun;72(6):4667-77
  • Viral Protein R Regulates Docking of the HIV-1 Preintegration Complex to the Nuclear Pore Complex
    Popov S, Rexach M, Ratner L, Blobel G, Bukrinsky M
    J Biol Chem 1998 May 22;273(21):13347-52
  • Selective Ablation of Human T-Cell Lymphotropic Virus Type 1 p12I Reduces Viral Infectivity in Vivo
    Collins ND, Newbound GC, Albrecht B, Beard JL, Ratner L, Lairmore MD
    Blood 1998 Jun 15;91(12):4701-7
  • Human T-Cell Leukemia Virus Type 1 PX-I and PX-II Open Reading Frames Are Dispensable for the Immortalization of Primary Lymphocytes
    Robek MD, Wong FH, Ratner L
    J Virol 1998 May;72(5):4458-62
  • Quantification of Human T-Cell Lymphotropic Virus Type 1 Proviral Load by Quantitative Competitive Polymerase Chain Reaction
    Albrecht B, Collins ND, Newbound GC, Ratner L, Lairmore MD
    J Virol Methods 1998 Nov;75(2):123-40
  • Human Immunodeficiency Virus Type 2 Vpx-Gag Interaction
    Pancio HA, Ratner L
    J Virol 1998 Jun;72(6):5271-5
  • Arginine Residues in the C-Terminus of HIV-1 Vpr Are Important for Nuclear Localization and Cell Cycle Arrest
    Zhou Y, Lu Y, Ratner L
    Virology 1998 Mar 15;242(2):414-24
  • Viral Protein R Regulates Nuclear Import of the HIV-1 Pre-Integration Complex
    Popov S, Rexach M, Zybarth G, Reiling N, Lee MA, Ratner L, Lane CM, Moore MS, Blobel G, Bukrinsky M
    EMBO J 1998 Feb 16;17(4):909-17
  • Cytokine Expression and Tumorigenicity of Large Granular Lymphocytic Leukemia Cells From Mice Transgenic for the Tax Gene of Human T-Cell Leukemia Virus Type I
    Grossman WJ, Ratner L
    Blood 1997 Jul 15;90(2):783-94
  • Membrane Binding of Human Immunodeficiency Virus Type 1 Matrix Protein in Vivo Supports a Conformational Myristyl Switch Mechanism
    Spearman P, Horton R, Ratner L, Kuli-Zade I
    J Virol 1997 Sep;71(9):6582-92
  • The Tax Protein of Human T-Cell Leukemia Virus Type 1 Mediates the Transactivation of the c-Sis/Platelet-Derived Growth Factor-B Promoter Through Interactions With the Zinc Finger Transcription Factors Sp1 and NGFI-A/Egr-1
    Trejo SR, Fahl WE, Ratner L
    J Biol Chem 1997 Oct 24;272(43):27411-21
  • In Vitro CD4+ Lymphocyte Transformation and Infection in a Rabbit Model With a Molecular Clone of Human T-Cell Lymphotrophic Virus Type 1
    Collins ND, Newbound GC, Ratner L, Lairmore MD
    J Virol 1996 Oct;70(10):7241-6
  • Genetic Determinants Controlling HIV-1 Tropism for CD4-/GalCer+ Human Intestinal Epithelial Cells: Importance of the V3 Loop
    Yahi N, Ratner L, Harouse JM, Gonzalez-Scarano F, Fantini J
    Perspective in Drug Discovery & Design 1996;5:161-8
  • c-Sis/PDGF-B Promoter Transactivation by the Tax Protein of Human T-Cell Leukemia Virus Type 1
    Trejo SR, Fahl WE, Ratner L
    J Biol Chem 1996 Jun 14;271(24):14584-90
  • Sequence Heterogeneity of Nef Transcripts in HIV-1-Infected Subjects at Different Stages of Disease
    Ratner L, Joseph T, Bandres J, Ghosh S, Vander Heyden N, Templeton A, Hahn B, Powderly W, Arens M
    Virology 1996 Sep 1;223(1):245-50
  • Human Immunodeficiency Virus Type 1 Capsid Formation in Reticulocyte Lysates
    Spearman P, Ratner L
    J Virol 1996 Nov;70(11):8187-94
  • Cooperative Effects of the Human Immunodeficiency Virus Type 1 Envelope Variable Loops V1 and V3 in Mediating Infectivity for T Cells
    Carrillo A, Ratner L
    J Virol 1996 Feb;70(2):1310-6
  • Human Immunodeficiency Virus Type 1 Tropism for T-Lymphoid Cell Lines: Role of the V3 Loop and C4 Envelope Determinants
    Carrillo A, Ratner L
    J Virol 1996 Feb;70(2):1301-9
  • Sera From HIV-1 Infected Individuals in All Stages of Disease Preferentially Recognize the V3 Loop of the Prototypic Macrophage-Tropic Glycoprotein gp120 ADA
    Ebenbichler C, McNearney T, Stoiber H, Most J, Zangerle R, Vogetseder W, Patsch JR, Ratner L, Dierich MP
    Mol Immunol 1995 Oct;32(14-15):1039-45
  • A Leucine Triplet Repeat Sequence (LXX)4 in p6gag Is Important for Vpr Incorporation Into Human Immunodeficiency Virus Type 1 Particles
    Lu YL, Bennett RP, Wills JW, Gorelick R, Ratner L
    J Virol 1995 Nov;69(11):6873-9
  • Nef and LTR Sequence Variation From Sequentially Derived Human Immunodeficiency Virus Type 1 Isolates
    McNearney T, Hornickova Z, Templeton A, Birdwell A, Arens M, Markham R, Saah A, Ratner L
    Virology 1995 Apr 1;208(1):388-98
  • Weekly Oral Etoposide in Patients With Kaposi's Sarcoma Associated With Human Immunodeficiency Virus Infection: A Phase I Multicenter Trial of the AIDS Clinical Trials Group
    Paredes J, Kahn JO, Tong WP, Feldstein ML, Lin S, Bennett JM, Metroka CE, Ratner L, Krown SE
    J Acquir Immune Defic Syndr Hum Retrovirol 1995 Jun 1;9(2):138-44
  • HIV-1 V3 Envelope Sequences Required for Macrophage Infection
    Henkel T, Westervelt P, Ratner L
    AIDS 1995 Apr;9(4):399-401
  • Development of Leukemia in Mice Transgenic for the Tax Gene of Human T-Cell Leukemia Virus Type I
    Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L
    Proc Natl Acad Sci U S A 1995 Feb 14;92(4):1057-61
  • HIV-1 Nef Protein Downregulation of CD4 Surface Expression: Relevance of the Lck Binding Domain of CD4
    Bandres JC, Shaw AS, Ratner L
    Virology 1995 Feb 20;207(1):338-41
  • Construction and Characterization of Infectious Human T-Cell Leukemia Virus Type 1 Molecular Clones
    Kimata JT, Wong FH, Wang JJ, Ratner L
    Virology 1994 Nov 1;204(2):656-64
  • The Vpr Protein of Human Immunodeficiency Virus Type 1 Influences Nuclear Localization of Viral Nucleic Acids in Nondividing Host Cells
    Heinzinger NK, Bukinsky MI, Haggerty SA, Ragland AM, Kewalramani V, Lee MA, Gendelman HE, Ratner L, Stevenson M, Emerman M
    Proc Natl Acad Sci U S A 1994 Jul 19;91(15):7311-5
  • Regulation of Human Immunodeficiency Virus Nef Protein by Phosphorylation
    Bandres JC, Luria S, Ratner L
    Virology 1994 May 15;201(1):157-61
  • Particle Assembly and Vpr Expression in Human Immunodeficiency Virus Type 1-Infected Cells Demonstrated by Immunoelectron Microscopy
    Wang JJ, Lu Y, Ratner L
    J Gen Virol 1994 Oct;75 ( Pt 10):2607-14
  • Killing of Primary CD4+ T Cells by Non-Syncytium-Inducing Macrophage-Tropic Human Immunodeficiency Virus Type 1
    Yu X, McLane MF, Ratner L, O'Brien W, Collman R, Essex M, Lee TH
    Proc Natl Acad Sci U S A 1994 Oct 11;91(21):10237-41
  • CD3-Dependent Lymphocyte Activation by Human T Cell Leukaemia Virus Type I-Producing T Cells
    Kimata JT, Wong FH, Ratner L
    J Gen Virol 1994 Sep;75 ( Pt 9):2433-7
  • Identification of Human Immunodeficiency Virus Type 1 Gag Protein Domains Essential to Membrane Binding and Particle Assembly
    Spearman P, Wang JJ, Vander Heyden N, Ratner L
    J Virol 1994 May;68(5):3232-42
  • Structure and Expression of the Human T-Cell Leukemia Virus Type 1 Envelope Protein
    Paine E, Gu R, Ratner L
    Virology 1994 Mar;199(2):331-8
  • HIV-2 Viral Protein X Association With the GAG p27 Capsid Protein
    Horton R, Spearman P, Ratner L
    Virology 1994 Mar;199(2):453-7
  • Human Immunodeficiency Virus Type 1 Nef Protein Down-Regulates Transcription Factors NF-Kappa B and AP-1 in Human T Cells in Vitro After T-Cell Receptor Stimulation
    Bandres JC, Ratner L
    J Virol 1994 May;68(5):3243-9
  • Identification of HIV1 Determinants for T Lymphoid Cell Line Infection
    Carrillo A, Trowbridge DB, Westervelt P, Ratner L
    Virology 1993 Dec;197(2):817-24
  • Alterations in Spliced and Unspliced HIV-1-Specific RNA Detection in Peripheral Blood Mononuclear Cells of Individuals With Varying CD4-Positive Lymphocyte Counts
    Arens M, Joseph T, Nag S, Miller JP, Powderly WG, Ratner L
    AIDS Res Hum Retroviruses 1993 Dec;9(12):1257-63
  • Human Immunodeficiency Virus Type 1 Viral Protein R Localization in Infected Cells and Virions
    Lu YL, Spearman P, Ratner L
    J Virol 1993 Nov;67(11):6542-50
  • Role of HIV-1 Envelope V3 Loop Cleavage in Cell Tropism
    Gu R, Westervelt P, Ratner L
    AIDS Res Hum Retroviruses 1993 Oct;9(10):1007-15
  • Highly Localized Tracks of Human Immunodeficiency Virus Type 1 Nef in the Nucleus of Cells of a Human CD4+ T-Cell Line
    Murti KG, Brown PS, Ratner L, Garcia JV
    Proc Natl Acad Sci U S A 1993 Dec 15;90(24):11895-9
  • Myristoylation-Enhanced Binding of the HIV-1 Nef Protein to T Cell Skeletal Matrix
    Niederman TM, Hastings WR, Ratner L
    Virology 1993 Nov;197(1):420-5
  • Structure-Function Relationships of the HIV-1 Envelope V3 Loop Tropism Determinant: Evidence for Two Distinct Conformations
    Ebenbichler C, Westervelt P, Carrillo A, Henkel T, Johnson D, Ratner L
    AIDS 1993 May;7(5):639-46
  • The Mitogenic Activity of Human T-Cell Leukemia Virus Type I Is T-Cell Associated and Requires the CD2/LFA-3 Activation Pathway
    Kimata JT, Palker TJ, Ratner L
    J Virol 1993 Jun;67(6):3134-41
  • Cell Surface Proteins Binding to Recombinant Soluble HIV-1 and HIV-2 Transmembrane Proteins
    Ebenbichler CF, Roder C, Vornhagen R, Ratner L, Dierich MP
    AIDS 1993 Apr;7(4):489-95
  • HIV-1 Nef Protein Inhibits the Recruitment of AP-1 DNA-Binding Activity in Human T-Cells
    Niederman TM, Hastings WR, Luria S, Bandres JC, Ratner L
    Virology 1993 May;194(1):338-44
  • Mechanism of Action of N-Butyl Deoxynojirimycin in Inhibiting HIV-1 Infection and Activity in Combination With Nucleoside Analogs
    Ratner L, Vander Heyden N
    AIDS Res Hum Retroviruses 1993 Apr;9(4):291-7
  • Evolution of Sequence Divergence Among Human Immunodeficiency Virus Type 1 Isolates Derived From a Blood Donor and a Recipient
    McNearney T, Hornickova Z, Kloster B, Birdwell A, Storch GA, Polmar SH, Arens M, Ratner L
    Pediatr Res 1993 Jan;33(1):36-42
  • Human Immunodeficiency Virus Type 1 Nef Protein Inhibits NF-Kappa B Induction in Human T Cells
    Niederman TM, Garcia JV, Hastings WR, Luria S, Ratner L
    J Virol 1992 Oct;66(10):6213-9
  • Relationship of Human Immunodeficiency Virus Type 1 Sequence Heterogeneity to Stage of Disease
    McNearney T, Hornickova Z, Markham R, Birdwell A, Arens M, Saah A, Ratner L
    Proc Natl Acad Sci U S A 1992 Nov 1;89(21):10247-51
  • Dual Regulation of Silent and Productive Infection in Monocytes by Distinct Human Immunodeficiency Virus Type 1 Determinants
    Westervelt P, Henkel T, Trowbridge DB, Orenstein J, Heuser J, Gendelman HE, Ratner L
    J Virol 1992 Jun;66(6):3925-31
  • Macrophage Tropism Determinants of Human Immunodeficiency Virus Type 1 in Vivo
    Westervelt P, Trowbridge DB, Epstein LG, Blumberg BM, Li Y, Hahn BH, Shaw GM, Price RW, Ratner L
    J Virol 1992 Apr;66(4):2577-82
  • Role of Asparagine-Linked Glycosylation in Human Immunodeficiency Virus Type 1 Transmembrane Envelope Function
    Dedera DA, Gu RL, Ratner L
    Virology 1992 Mar;187(1):377-82
  • Conserved Cysteine Residues in the Human Immunodeficiency Virus Type 1 Transmembrane Envelope Protein Are Essential for Precursor Envelope Cleavage
    Dedera D, Gu RL, Ratner L
    J Virol 1992 Feb;66(2):1207-9
  • Demonstration of Two Distinct Cytopathic Effects With Syncytium Formation-Defective Human Immunodeficiency Virus Type 1 Mutants
    Dedera D, Ratner L
    J Virol 1991 Nov;65(11):6129-36
  • Structure and Expression of the c-Sis Gene and Its Relationship to Sporadic Meningiomas
    Smidt M, Dumanski JP, Collins VP, Ratner L
    Cancer Res 1991 Aug 15;51(16):4295-8
  • Nucleotide Sequence Analysis of Isolates of Human T-Lymphotropic Virus Type 1 of Diverse Geographical Origins
    Ratner L, Philpott T, Trowbridge DB
    AIDS Res Hum Retroviruses 1991 Nov;7(11):923-41
  • Temporal Regulation of Viral and Cellular Gene Expression During Human T-Lymphotropic Virus Type I-Mediated Lymphocyte Immortalization
    Kimata JT, Ratner L
    J Virol 1991 Aug;65(8):4398-407
  • Simian Immunodeficiency Virus Negative Factor Suppresses the Level of Viral mRNA in COS Cells
    Niederman TM, Hu W, Ratner L
    J Virol 1991 Jul;65(7):3538-46
  • Identification of a Determinant Within the Human Immunodeficiency Virus 1 Surface Envelope Glycoprotein Critical for Productive Infection of Primary Monocytes
    Westervelt P, Gendelman HE, Ratner L
    Proc Natl Acad Sci U S A 1991 Apr 15;88(8):3097-101
  • Limited Sequence Variation in Human T-Lymphotropic Virus Type 1 Isolates From North American and African Patients
    Paine E, Garcia J, Philpott TC, Shaw G, Ratner L
    Virology 1991 May;182(1):111-23
  • Formation of Noninfectious HIV-1 Virus Particles Lacking a Full-Length Envelope Protein
    Ratner L, Vander Heyden N, Garcia J, Polinsky M, Westervelt P, Becich M
    AIDS Res Hum Retroviruses 1991 Mar;7(3):287-94
  • Inhibition of HIV and SIV Infectivity by Blockade of Alpha-Glucosidase Activity
    Ratner L, Vander Heyden N, Dedera D
    Virology 1991 Mar;181(1):180-92
  • A Determinant Within the HIV-1 gp120 Envelope Protein Critical for Infection of Primary Monocytes
    Westervelt P, Gendelman HE, Li Y, Ratner L
    Vaccines 91, Cold Spring Harbor Laboratory Press, 71-6
  • Incorporation of 12-Methoxydodecanoate Into the Human Immunodeficiency Virus 1 Gag Polyprotein Precursor Inhibits Its Proteolytic Processing and Virus Production in a Chronically Infected Human Lymphoid Cell Line
    Bryant ML, Ratner L, Duronio RJ, Kishore NS, Devadas B, Adams SP, Gordon JI
    Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2055-9
  • Immunoblastic Lymphoma of T-Cell Type in a Chronically Immunosuppressed Renal Transplant Recipient
    Griffith RC, Saha BK, Janney CM, Ratner L, Brunt EM, Gajl-Peczalska KJ, Hanto DW
    Am J Clin Pathol 1990 Feb;93(2):280-5
  • Deletion of Alu Sequences in the Fifth c-Sis Intron in Individuals With Meningiomas
    Smidt M, Kirsch I, Ratner L
    J Clin Invest 1990 Oct;86(4):1151-7
  • Attenuation of HIV-1 Infectivity by an Inhibitor of Oligosaccharide Processing
    Dedera D, Vander Heyden N, Ratner L
    AIDS Res Hum Retroviruses 1990 Jun;6(6):785-94
  • Familial Adult T-Cell Leukemia/Lymphoma
    Ratner L, Vander Heyden N, Paine E, Frei-Lahr D, Brown R, Petruska P, Reddy S, Lairmore MD
    Am J Hematol 1990 Jul;34(3):215-22
  • Limited Sequence Heterogeneity Among Biologically Distinct Human Immunodeficiency Virus Type 1 Isolates From Individuals Involved in a Clustered Infectious Outbreak
    McNearney T, Westervelt P, Thielan BJ, Trowbridge DB, Garcia J, Whittier R, Ratner L
    Proc Natl Acad Sci U S A 1990 Mar;87(5):1917-21
  • Myristoylation-Dependent Replication and Assembly of Human Immunodeficiency Virus 1
    Bryant M, Ratner L
    Proc Natl Acad Sci U S A 1990 Jan;87(2):523-7
  • Replication of Human Immunodeficiency Virus 1 and Moloney Murine Leukemia Virus Is Inhibited by Different Heteroatom-Containing Analogs of Myristic Acid
    Bryant ML, Heuckeroth RO, Kimata JT, Ratner L, Gordon JI
    Proc Natl Acad Sci U S A 1989 Nov;86(22):8655-9
  • Analysis of the Function of Viral Protein X (VPX) of HIV-2
    Hu W, Vander Heyden N, Ratner L
    Virology 1989 Dec;173(2):624-30
  • Analogs of 3'-Amino-3'-Deoxyadenosine Inhibit HIV-1 Replication
    Vander Heyden N, Rodi C, Ratner L
    AIDS Res Hum Retroviruses 1989 Dec;5(6):647-53
  • Viral Protein R of Human Immunodeficiency Virus Types 1 and 2 Is Dispensable for Replication and Cytopathogenicity in Lymphoid Cells
    Dedera D, Hu W, Vander Heyden N, Ratner L
    J Virol 1989 Jul;63(7):3205-8
  • Role of the Carboxy-Terminal Portion of the HIV-1 Transmembrane Protein in Viral Transmission and Cytopathogenicity
    Lee SJ, Hu W, Fisher AG, Looney DJ, Kao VF, Mitsuya H, Ratner L, Wong-Staal F
    AIDS Res Hum Retroviruses 1989 Aug;5(4):441-9
  • Human Immunodeficiency Virus Type 1 Negative Factor Is a Transcriptional Silencer
    Niederman TM, Thielan BJ, Ratner L
    Proc Natl Acad Sci U S A 1989 Feb;86(4):1128-32
  • Specificity of Polymerase Chain Amplification Reactions for Human Immunodeficiency Virus Type 1 DNA Sequences
    Bell J, Ratner L
    AIDS Res Hum Retroviruses 1989 Feb;5(1):87-95
  • Regulation of Expression of the c-Sis Proto-Oncogene
    Ratner L
    Nucleic Acids Res 1989 Jun 12;17(11):4101-15
  • Leukemias Associated With Human T-Cell Lymphotropic Virus Type I in a Non-Endemic Region
    Ratner L, Poiesz BJ
    Medicine (Baltimore) 1988 Nov;67(6):401-22
  • The Sor Gene of HIV-1 Is Required for Efficient Virus Transmission in Vitro
    Fisher AG, Ensoli B, Ivanoff L, Chamberlain M, Petteway S, Ratner L, Gallo RC, Wong-Staal F
    Science 1987 Aug 21;237(4817):888-93
  • Sequences of the 5' Portion of the Human c-Sis Gene: Characterization of the Transcriptional Promoter and Regulation of Expression of the Protein Product by 5' Untranslated mRNA Sequences
    Ratner L, Thielan B, Collins T
    Nucleic Acids Res 1987 Aug 11;15(15):6017-36
  • Cytotoxic Factors Secreted by Cells Infected by Human Immunodeficiency Virus Type I
    Ratner L, Polmar SH, Paul N, Ruddle N
    AIDS Res Hum Retroviruses 1987 Summer;3(2):147-55
  • Trans-Activation of Long Terminal Repeat Sequence-Mediated Gene Expression Is Not a Property of Type D Retrovirus Replication
    Thielan BJ, Hunter E, Desrosiers RC, Ratner L
    J Gen Virol 1987 Aug;68 ( Pt 8):2265-70
  • Complete Nucleotide Sequences of Functional Clones of the AIDS Virus
    Ratner L, Fisher A, Jagodzinski LL, Mitsuya H, Liou RS, Gallo RC, Wong-Staal F
    AIDS Res Hum Retroviruses 1987 Spring;3(1):57-69
  • A Lymphoproliferative Disorder Caused by Human T-Lymphotropic Virus Type I. Demonstration of a Continuum Between Acute and Chronic Adult T-Cell Leukemia/Lymphoma
    Ratner L, Griffith RC, Marselle L, Hoh M, Wong-Staal F, Saxinger C
    Am J Med 1987 Nov;83(5):953-8
  • Delta Hepatitis Outbreak in a Group of Patients With Leukemia
    Ratner L
    Ann Intern Med 1986 Dec;105(6):972
  • Infectious Mutants of HTLV-III With Changes in the 3' Region and Markedly Reduced Cytopathic Effects
    Fisher AG, Ratner L, Mitsuya H, Marselle LM, Harper ME, Broder S, Gallo RC, Wong-Staal F
    Science 1986 Aug 8;233(4764):655-9
  • Adverse Prognostic Influence of Hepatitis B Virus Infection in Acute Lymphoblastic Leukemia
    Ratner L, Peylan-Ramu N, Wesley R, Poplack DG
    Cancer 1986 Sep 1;58(5):1096-100
  • Transactivation Induced by Human T-Lymphotropic Virus Type III (HTLV III) Maps to a Viral Sequence Encoding 58 Amino Acids and Lacks Tissue Specificity
    Seigel LJ, Ratner L, Josephs SF, Derse D, Feinberg MB, Reyes GR, O'Brien SJ, Wong-Staal F
    Virology 1986 Jan 15;148(1):226-31
  • Polymorphism of the 3' Open Reading Frame of the Virus Associated With the Acquired Immune Deficiency Syndrome, Human T-Lymphotropic Virus Type III
    Ratner L, Starcich B, Josephs SF, Hahn BH, Reddy EP, Livak KJ, Petteway SR Jr, Pearson ML, Haseltine WA, Arya SK, et al
    Nucleic Acids Res 1985 Nov 25;13(22):8219-29
  • Nucleotide Sequence of Transforming Human c-Sis cDNA Clones With Homology to Platelet-Derived Growth Factor
    Ratner L, Josephs SF, Jarrett R, Reitz MS Jr, Wong-Staal F
    Nucleic Acids Res 1985 Jul 25;13(14):5007-18
  • A Molecular Clone of HTLV-III With Biological Activity
    Fisher AG, Collalti E, Ratner L, Gallo RC, Wong-Staal F
    Nature 1985 Jul 18-24;316(6025):262-5
  • HTLV-III, LAV, ARV Are Variants of Same AIDS Virus
    Ratner L, Gallo RC, Wong-Staal F
    Nature 1985 Feb 21-27;313(6004):636-7
  • Nucleotide Sequence Analysis of a Variant Human T-Cell Leukemia Virus (HTLV-Ib) Provirus With a Deletion in PX-I
    Ratner L, Josephs SF, Starcich B, Hahn B, Shaw GM, Gallo RC, Wong-Staal F
    J Virol 1985 Jun;54(3):781-90
  • Characterization of Long Terminal Repeat Sequences of HTLV-III
    Starcich B, Ratner L, Josephs SF, Okamoto T, Gallo RC, Wong-Staal F
    Science 1985 Feb 1;227(4686):538-40
  • Complete Nucleotide Sequence of the AIDS Virus, HTLV-III
    Ratner L, Haseltine W, Patarca R, Livak KJ, Starcich B, Josephs SF, Doran ER, Rafalski JA, Whitehorn EA, Baumeister K, et al
    Nature 1985 Jan 24-30;313(6000):277-84
  • Transforming Potential of Human c-Sis Nucleotide Sequences Encoding Platelet-Derived Growth Factor
    Josephs SF, Ratner L, Clarke MF, Westin EH, Reitz MS, Wong-Staal F
    Science 1984 Aug 10;225(4662):636-9
  • Transformation of NIH 3T3 Cells by a Human c-Sis cDNA Clone
    Clarke MF, Westin E, Schmidt D, Josephs SF, Ratner L, Wong-Staal F, Gallo RC, Reitz MS Jr
    Nature 1984 Mar 29-Apr 4;308(5958):464-7
  • Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus
    Josephs SF, Guo C, Ratner L, Wong-Staal F
    Science 1984 Feb 3;223(4635):487-91
  • Interferon as an Inhibitor of Cell Growth: Studies With Mouse Melanoma Cells
    Ratner L, Nordlund JJ, Lengyel P
    Proc Soc Exp Biol Med 1980 Feb;163(2):267-72
  • Studies of Interferon Action: (A) Characteristics of a Double-Stranded RNA Activated Endoribonuclease; (B) Effect on Cell Replication
    Ratner L
    PhD thesis, Yale University
  • Interferon-Associated, DsRNA-Dependent Enzyme Activities in a Mutant 3T6 Cell Engaged in the Semiconstitutive Synthesis of Interferon
    Jarvis AP, White C, Ball A, Gupta SL, Ratner L, Sen GC, Colby C
    Cell 1978 Aug;14(4):879-87
  • Interferon Action: Two Distinct Pathways for Inhibition of Protein Synthesis by Double-Stranded RNA
    Farrell PJ, Sen GC, Dubois MF, Ratner L, Slattery E, Lengyel P
    Proc Natl Acad Sci U S A 1978 Dec;75(12):5893-7
  • Interferon, Double-Stranded RNA and RNA Degradation. Fractionation of the EndonucleaseINT System Into Two Macromolecular Components; Role of a Small Molecule in Nuclease Activation
    Ratner L, Wiegand RC, Farrell PJ, Sen GC, Cabrer B, Lengyel P
    Biochem Biophys Res Commun 1978 Apr 14;81(3):947-54
  • Interferon, Double-Stranded RNA and RNA Degradation. Characteristics of an Endonuclease Activity
    Ratner L, Sen GC, Brown GE, Lebleu B, Kawakita M, Cabrer B, Slattery E, Lengyel P
    Eur J Biochem 1977 Oct 3;79(2):565-77

Review Articles

  • The Past, Present, and Future of a Human T-Cell Leukemia Virus Type 1 Vaccine
    Tu JJ, Maksimova V, Ratner L, Panfil AR
    Front Microbiol 2022 May 4;13:897346
  • HIV-Associated Malignancies
    Ratner L
    In: The Washington Manual of Oncology, 4th Edition (Morgensztern D, Ghobadi A, Govindan R, Editors), Wolters Kluwer, Philadelphia, 2022
  • Epigenetic Regulation of Human T-Cell Leukemia Virus Gene Expression
    Ratner L
    Microorganisms 2021 Dec 31;10(1):84
  • Predicting the Future: Adult T-Cell Leukemia
    Ratner L
    Blood 2020 Jun 4;135(23):2013-2014
  • Molecular Biology of Human T Cell Leukemia Virus
    Ratner L
    Semin Diagn Pathol 2020 Mar;37(2):104-109
  • Biomarkers and Preclinical Models for Adult T-Cell Leukemia-Lymphoma Treatment
    Ratner L
    Front Microbiol 2019 Sep 18;10:2109
  • Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report
    Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
    J Clin Oncol 2019 Mar 10;37(8):677-687
  • AIDS-Related Kaposi Sarcoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology
    Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Crysler OV, Gupta N, Gustafson C, Hall A, Johung KL, Klopp A, LaCasce AS, Lin C, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Ratner L, Rizza S, Rudek MA, Sanchez J, Taylor J, Tomlinson B, Wang CJ, Yendamuri S, Dwyer MA, Freedman-Cass DA
    J Natl Compr Canc Netw 2019 Feb;17(2):171-189
  • Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology
    Reid E, Suneja G, Ambinder RF, Ard K, Baiocchi R, Barta SK, Carchman E, Cohen A, Gupta N, Johung KL, Klopp A, LaCasce AS, Lin C, Makarova-Rusher OV, Mehta A, Menon MP, Morgan D, Nathwani N, Noy A, Palella F, Ratner L, Rizza S, Rudek MA, Taylor J, Tomlinson B, Wang CJ, Dwyer MA, Freedman-Cass DA
    J Natl Compr Canc Netw 2018 Aug;16(8):986-1017
  • Oncogenic Viruses
    Buck C, Ratner L, Tosato G
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th edition, Lippincott, Williams & Wilkins, Chapter 5, pp 98-114, 2018
  • Adult T-Cell Leukemia/Lymphoma
    Mehta-Shah N, Ratner L, Horwitz SM
    J Oncol Pract 2017 Aug;13(8):487-492
  • Human T-Lymphotrophic Viruses (1 and 2)
    Spearman P, Ratner L
    In: 21st edition of Nelson Textbook of Pediatrics, 2017, in press
  • Human T-Cell Leukemia Virus-Associated Malignancy
    Panfil AR, Martinez MP, Ratner L, Green PL
    Curr Opin Virol 2016 Oct;20:40-46
  • Contribution of Inducible Nitric Oxide Synthase to the Transformation of HTLV-1 Infected CD4+ T-Cells
    Baydoun HH, Ratner L
    Journal of Leukemia 2015
  • How Does HTLV-1 Cause Adult T-Cell Leukaemia/Lymphoma (ATL)?
    Bangham CR, Ratner L
    Curr Opin Virol 2015 Oct;14:93-100
  • Oncogenic Viruses
    Buck C, Ratner L
    In: DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, 10th Edition, Lippincott, Williams & Wilkins, Chapter 5, pp 69-82, 2015
  • AIDS Related Malignancies
    Ratner L
    In: Govindin R, Morenszstern D, eds. Washington Manual of Oncology, Lippincott, in press 2015
  • Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26-30 June 2013, Montreal, Canada
    Barbeau B, Hiscott J, Bazarbachi A, Carvalho E, Jones K, Martin F, Matsuoka M, Murphy EL, Ratner L, Switzer WM, Watanabe T
    Retrovirology 2014 Feb 24;11(1):19
  • Immunosuppression-Related Malignancies
    Ratner L
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Pracice of Oncology Review (R Govindan, Ed.), Lippincott, Williams & Wilkins, 2011; pp 499-503
  • Molecular Determinants of Human T-Lymphotropic Virus Type 1 Transmission and Spread
    Lairmore MD, Anupam R, Bowden N, Haines R, Haynes RA 2nd, Ratner L, Green PL
    Viruses 2011 Jul;3(7):1131-65
  • Targeting HTLV-1 Activation of NFkappaB in Mouse Models and ATLL Patients
    Rauch DA, Ratner L
    Viruses 2011 Jun;3(6):886-900
  • HIV and Cancer
    Ratner L, Pantoanowitz L
    inPractice (www.inpractice.com)
  • JAK Blockade and HTLV
    Ratner L
    Blood 2011 Feb 10;117(6):1771-2
  • Book Review of "Human Cancer Viruses: Principles of Transformation and Pathogenesis; Edited by J. Nicholas, K.-T. Jeang, and T.C. Wu"
    Ratner L
    N Engl J Med 2009;360:312-3
  • Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting
    Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W Jr, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T
    J Clin Oncol 2009 Jan 20;27(3):453-9
  • HIV Preintegration Complexes
    Ratner L
    In: Gallo, R. (ed.), Retroviruses: Biology, Pathogenic Mechanisms and Treatment, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0401709-Ratner)
  • AIDS Related Malignancies
    Ratner L, Tan B
    In: The Washington Manual of Oncology, Second Edition (R Govindan, ed) Lippincott Williams and Wilkins, Chapter 30, 2007
  • Cytokines in HTLV-1 Cytokines and Cancer
    Lairmore M, Ratner L
    In: Cytokines in the Genesis and Treatment of Cancer (M Caligiuri and M Lotze, eds), Humana Press Inc. USA, 2007; pp 27-51
  • Immusupression-Related Malignancies
    Tan B, Ratner L
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Review, R Govindan (ed), Lippincott, Williams & Wilkins, pp 424-428, 2005
  • Human T Cell Lymphotropic Virus-Associated Leukemia/Lymphoma
    Ratner L
    Curr Opin Oncol 2005 Sep;17(5):469-73
  • Animal Models for Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection and Transformation
    Lairmore MD, Silverman L, Ratner L
    Oncogene 2005 Sep 5;24(39):6005-15
  • Pathogenesis and Treatment of Human T-Cell Leukemia Virus Infection
    Ratner L
    Immunol Res 2005;32(1-3):217-24
  • Adult T Cell Leukemia Lymphoma
    Ratner L
    Front Biosci 2004 Sep 1;9:2852-9
  • AIDS-Related Lymphomas
    Smukler AJ, Tan B, Ratner L
    Contemporary Oncology 2003 Aug 15;2:1-11
  • Tumorigenesis With Transgenic Expression of Human T Cell Leukmia Virus Tax
    Ratner L
    Sugamura K, ed. Two decades of adult T cell leukemia and HTLV-I research: progress in basic research and its implications in clinical advances, Gann Monograph #50 on Cancer Research, Tokyo, Japan, pp 231-240
  • Hepatitis Viruses and Hepatocellular Carcinoma in HIV-Infected Patients
    Smukler AJ, Ratner L
    Curr Opin Oncol 2002 Sep;14(5):538-42
  • AIDS Related Malignancies
    Tan B, Ratner L
    In: Govindin R, Arquette MA, eds. Washington Manual of Oncology, Lippincott, Chapter 6, pp 100-111
  • Multidrug Resistance Transporters and Modulation
    Tan B, Piwnica-Worms D, Ratner L
    Curr Opin Oncol 2000 Sep;12(5):450-8
  • Studies of the Immortalizing Activity of HTLV Type 1 Tax, Using an Infectious Molecular Clone and Transgenic Mice
    Ratner L, Portis T, Robek M, Harding J, Grossman W
    AIDS Res Hum Retroviruses 2000 Nov 1;16(16):1647-51
  • Role of Tax in HTLV-1 Transformation: Studies With an Infectious Proviral Clone and Transgenic Mice
    Ratner L, Robek M, Grossman W
    In:  Hammarskjold M-L and Semmes OJ, Molecular Pathogenesis of HTLV-1,Vandamere Press, p 131-136, 1998
  • The Use of New Antiretroviral Therapy in Combination With Chemotherapy
    Tan B, Ratner L
    Curr Opin Oncol 1997 Sep;9(5):455-64
  • AIDS 1997. Virology: Overview
    Harada S, Ratner L
    AIDS 1997;11 Suppl A:S1-2
  • Virology
    Ratner L, Fenyo EM
    AIDS 1996;10 Suppl A:S1-2
  • Transgenic Mouse Models for HTLV-I Infection
    Grossman WJ, Ratner L
    J Acquir Immune Defic Syndr Hum Retrovirol 1996;13 Suppl 1:S162-9
  • Genetic Organization of HIV
    Ratner L
    In: Gupta A, Immunology of HIV Infection, Plenum Press, New York, pp. 3-22, 1996
  • Animal Models of HTLV-1 Infection
    Ratner L
    In: Hollsberg P, ed. Human T-cell Lymphotropic Viruses, Chap 12, John Wiley & Sons, Ltd, pp 287-307, 1996
  • Nef
    Ratner L, Niederman TM
    Curr Top Microbiol Immunol 1995;193:169-208
  • Systemic Treatment of Kaposi's Sarcoma: Current Status and Future Directions
    Lilenbaum RC, Ratner L
    AIDS 1994 Feb;8(2):141-51
  • Viral Life Cycle and Genetic Approaches
    Ratner L
    Perspectives in Drug Discovery and Design. 1:3-22, 1993
  • Molecular Biology and Pathogenesis of HIV
    Ratner L
    In: Burke D, ed. HIV Infections and AIDS. Current Opinion in Infectious Diseases vol 6, no 2, 6:181-190, 1993
  • CNS Lymphomas Associated With AIDS
    Ratner L
    In: Levine AJ, Schmidek HH, eds. Molecular Genetics of Nervous System Tumors, Wiley-Liss, New York, Chap 30, pp 329-340, 1992
  • Biology and Molecular Biology of Human Immunodeficiency Virus
    Bryant ML, Ratner L
    Pediatr Infect Dis J 1992 May;11(5):390-400
  • Functional Analysis of HIV1 and SIV Nef Proteins
    Niederman TM, Ratner L
    Res Virol 1992 Jan-Feb;143(1):43-6
  • Glucosidase Inhibitors for Treatment of HIV-1 Infection
    Ratner L
    AIDS Res Hum Retroviruses 1992 Feb;8(2):165-73
  • HIV Sequence Heterogeneity, Diverse Levels of Diversity
    McNearney T, Ratner L
    AIDS Targeted Information Newsletter, Sept. 1991
  • Structure and Function of HIV and SIV Nef Protducts
    Ratner L, Niederman TJ, Lozeron H, Bryant M.
    In: Haseltine W, ed. The Genetic Structure and Regualtion of HIV, Raven Press, New York pp 437-450, 1991
  • Structure and Fucntion of the Negative Factor (NEF) of HIV and SIV
    Ratner L, Niederman TJ, Lozeron H, Bryant M.
    In: Kumar A, ed. Advances in Molecular Biology and Targeted Treatment of AIDS. Plenum Press, pp 203-216, 1991
  • The Biology and Molecular Biology of HIV
    Bryant M, Ratner L
    In: Pizzo PA, Wilfert CA, eds. Pediatric AIDS: The Challenge of HIV Infection in Infants, Children, and Adolexcents. Williams & Wilkins, pp 53-74, 1990
  • Molecular Variation Among HTLV Isolates
    Ratner L
    In: Blattner W, ed. Human Retrovirology, HTLV, Raven Press, New York, pp 49-64, 1990
  • Human T-Lymphotropic Retroviruses (HTLV-I, HTLV-II)
    Ratner L, Wong-Staal F
    In: O'Brien S, ed. Genetic Maps, Cold Spring Harbor Press, 5th edition, pp 1.160-1.161, 1990
  • Role of the Negative Factors (NEF) in HIV and SIV Replication
    Ratner L
    AIDS Targeted Information Newsletter 3:1-2, March 1989
  • Measurement of Human Immunodeficiency Virus Load and Its Relation to Disease Progression
    Ratner L
    AIDS Res Hum Retroviruses 1989 Apr;5(2):115-9
  • Human Immunodeficiency Virus-Associated Autoimmune Thrombocytopenic Purpura: A Review
    Ratner L
    Am J Med 1989 Feb;86(2):194-8
  • The Human Immunodeficiency Virus Protease and Its Role in Virus Replciation
    Ratner L
    Minireview. AIDS Targeted Information Newsletter. 2:1-2, February 1988
  • The Family of Immunosuppressive Human Retroviruses
    Ratner L
    Minireview. AIDS Targeted Information Newsletter 1:1-3, June, 1987
  • Is the HIV Envelope Guilty of Murder?
    Ratner L
    Minireview. AIDS Targeted Information Newsletter 1:1-2, January 1987
  • Mechanism of Leukemogenesis by Human T-Cell Leukemia Virus Types I and II: Role of the Lor Gene
    Ratner L, Sodroski JG, Wong-Staal F, Haseltine WA, Shaw GM, Gallo RC
    Cancer Detect Prev 1987;10(5-6):411-24
  • Complete Nucleotide Sequences of Functional Clones of the Virus Associated With the Acquired Immunodeficiency Syndrome, HTLV-III/LAV
    Ratner L, Fisher A, Jagodzinski LL, Liou RS, Mitsuya H, Gallo RC, Wong-Staal F
    Hamatol Bluttransfus 1987;31:404-6
  • Complete Nucleotide Sequence of the AIDS Virus, HTLV-III
    Ratner L, Haseltine W, Patarca R, Livak KJ, Starcich B, Josephs SF, Doran ER, Rafalski A, Whitehorn EA, Baumeister K, Ivanoff L, Petteway SR, Pearson ML, Lauenberger JA, Papas TS, Ghrayeb J, Chang NT, Callo RC, Wong-Staal F
    In: Rivera DS, ed. 1986 Year Book of Cancer, Houston, U of Texas, MD Anderson Hospital Scientific Publications.
  • Human T Cell Lymphotropic Viruses and Their Family of Diseases
    Ratner L, Gallo RC
    In: Notkins AB, Oldstone MB, eds. Concepts in Clinical Pathogenesis II. New York, Springer-Verlag, pp 257-260, 1985
  • Structure and Function of Human Retroviruses
    Ratner L, Gallo RC
    In: Gustafson JP, ed. Genetics, Molecules, and Evolution. New York, Plenum Publishing, pp 307-342, 1985
  • Molecular Biology of Human T-Lymphotropic Retroviruses
    Wong-Staal F, Ratner L, Shaw G, Hahn B, Harper M, Franchini G, Gallo R
    Cancer Res 1985 Sep;45(9 Suppl):4539s-4544s
  • Oncogenes: Their Role in Neoplastic Transformation
    Ratner L, Josephs SF, Wong-Staal F
    Annu Rev Microbiol 1985;39:419-49
  • The Family of Human T-Lymphotropic Retroviruses Called Human T-Cell Leukemia/Lymphoma Virus (HTLV): Their Role in Lymphoid Malignancies and Lymphosuppressive Disorders (AIDS)
    Gallo RC, Ratner L, Popovic M, Salahuddin SZ, Sarngadharan MG, Wong-Staal F, Shaw G, Hahn B, Markam PD, Groopman J, Safai B, Reitz M, Robert-Guroff M
    In: Marks PA, ed. Genetics, Cell Differentiation, and Cancer, New York, Academic Press, 1985
  • Oncogenes and Cellular Transformation by Human T-Cell Leukemia Virus
    Ratner L, Wong-Staal F, Gallo RC
    In: Andersson LC, Gahmberg CG, Ekbom P, eds. Gene Expression During Normal and Malignant Differentiation. Academic Press, pp. 183-209, 1985
  • Human and Primate T-Lymphotropic Retroviruses (HTLV & PTLV) Subtypes, Biological Activity, and Role in Neoplasms
    Ratner L, Sarin PS, Wong-Staal F, Gallo RC
    In: Rigby WJ, Wilkie NM, eds. Viruses and Cancer. Cambridge University Press, pp 261-289, 1985
  • Cellular Transformation by Human T-Cell Leukemia Virus: Possible Role of T-Cell Growth Factor and Platelet-Derived Growth Factor
    Ratner L, Arya S, Wong-Staal F, Gallo RC
    In: Czech MP, Kahn CR, eds. Membrane Receptors and Cellular Recognition, UCLA Symposia on Molecular and Cellular Biology, New Series, vol 23, New York, Alan R Liss, Inc pp 357-367, 1985
  • Cloning Human Oncogenes
    Ratner L, Gallo RC, Wong-Staal F
    In: Becker E, ed. Recombinant DNA Research, Martinus Nijhoff Publishing, pp. 15-35, 1985
  • Molecular Characterization of Human T-Lymphotropic Leukemia Virus Type III Associated With the Acquired Immunodeficiency Syndrome
    Wong-Staal F, Hahn BH, Shaw GM, Arya SK, Harper M, Gonda M, Gilden R, Ratner L, Starcich B, Okamoto T, et al.
    Princess Takamatsu Symp 1984;15:291-300
  • Biochemistry of the Interferon System
    Lengyel P, Desrosiers R, Broeze R, Slattery E, Taira H, Dougherty J, Samata H, Pichon J, Farrell P, Ratner L, Sen GC
    Microbiology, pp. 219, 1980
  • Messenger RNA Methylation, Translation and Degradation in Extracts of Interferon-Treated Cells
    Sen GC, Desrosiers R, Ratner L, Shaila S, Brown GE, Lebleu B, Slattery E, Kawakita M, Cabrer B, Taira H, Lengyel P
    Tex Rep Biol Med 1977;35:221-9
  • Double Stranded RNA and the Mechanism of Interferon Action, a Progress Report
    Lengyel P, Sen GC, Desrosiers R, Ratner L, Shaila S, Brown GE, Lebleu B, Kawakita M, Cabrer B, Taira H, Slattery E
    In: Chakravorty M, ed. Molecular Basis of Host-Virus Interaction. Princeton, New Jersey, Science Press, 1976