Oncology Division
Alphabetical list (active faculty):   
George P. Souroullas

George P. Souroullas, PhD

Assistant Professor

Department of Medicine

Oncology Division

Molecular Oncology

Research Interests

  • Epigenetic mechanisms
  • B cell lymphoma
  • Melanoma


Original Articles

  • Ezh2(Y641F) Mutations Co-Operate With Stat3 to Regulate MHC Class I Antigen Processing and Alter the Tumor Immune Response in Melanoma
    Zimmerman SM, Nixon SJ, Chen PY, Raj L, Smith SR, Paolini RL, Lin PN, Souroullas GP
    Oncogene 2022 Nov;41(46):4983-4993
  • EZH2 Overexpression in Multiple Myeloma: Prognostic Value, Correlation With Clinical Characteristics, and Possible Mechanisms
    Goldsmith SR, Fiala MA, O'Neal J, Souroullas GP, Toama W, Vij R, Schroeder MA
    Clin Lymphoma Myeloma Leuk 2019 Nov;19(11):744-750
  • Cells Exhibiting Strong P16 (INK4a) Promoter Activation in Vivo Display Features of Senescence
    Liu JY, Souroullas GP, Diekman BO, Krishnamurthy J, Hall BM, Sorrentino JA, Parker JS, Sessions GA, Gudkov AV, Sharpless NE
    Proc Natl Acad Sci U S A 2019 Feb 12;116(7):2603-2611
  • Lkb1 Deletion in Murine B Lymphocytes Promotes Cell Death and Cancer
    Souroullas GP, Fedoriw Y, Staudt LM, Sharpless NE
    Exp Hematol 2017 Jul;51:63-70e1
  • An Oncogenic Ezh2 Mutation Induces Tumors Through Global Redistribution of Histone 3 Lysine 27 Trimethylation
    Souroullas GP, Jeck WR, Parker JS, Simon JM, Liu JY, Paulk J, Xiong J, Clark KS, Fedoriw Y, Qi J, Burd CE, Bradner JE, Sharpless NE
    Nat Med 2016 Jun;22(6):632-40
  • Comparison of Cesium-137 and X-Ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice
    Gibson BW, Boles NC, Souroullas GP, Herron AJ, Fraley JK, Schwiebert RS, Sharp JJ, Goodell MA
    Comp Med 2015 Jun;65(3):165-72
  • mTOR Signaling in Melanoma: Oncogene-Induced Pseudo-Senescence?
    Souroullas GP, Sharpless NE
    Cancer Cell 2015 Jan 12;27(1):3-5
  • Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma
    Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NE
    Cancer Discov 2014 Dec;4(12):1418-29
  • Stem Cells: Down's Syndrome Link to Ageing
    Souroullas GP, Sharpless NE
    Nature 2013 Sep 19;501(7467):325-6
  • Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery
    Kahle JJ*, Souroullas GP*, Yu P, Zohren F, Lee Y, Shaw CA, Zoghbi HY, Goodell MA (*co-first authors)
    PLoS Genet 2013 Mar;9(3):e1003359
  • The Transcription Factor Lyl-1 Regulates Lymphoid Specification and the Maintenance of Early T Lineage Progenitors
    Zohren F, Souroullas GP, Luo M, Gerdemann U, Imperato MR, Wilson NK, Gottgens B, Lukov GL, Goodell MA
    Nat Immunol 2012 Jul 8;13(8):761-9
  • A New Allele of Lyl1 Confirms Its Important Role in Hematopoietic Stem Cell Function
    Souroullas GP, Goodell MA
    Genesis 2011 Jun;49(6):441-8
  • The Expansion of T-Cells and Hematopoietic Progenitors as a Result of Overexpression of the Lymphoblastic Leukemia Gene, Lyl1 Can Support Leukemia Formation
    Lukov GL, Rossi L, Souroullas GP, Mao R, Goodell MA
    Leuk Res 2011 Mar;35(3):405-12
  • Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival
    Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA
    Cell Stem Cell 2009 Feb 6;4(2):180-6
  • Mechanistic Understanding of an Altered Fidelity Simian Immunodeficiency Virus Reverse Transcriptase Mutation, V148I, Identified in a Pig-Tailed Macaque
    Diamond TL, Souroullas G, Weiss KK, Lee KY, Bambara RA, Dewhurst S, Kim B
    J Biol Chem 2003 Aug 8;278(32):29913-24