Oncology Division Mail Stop 8007-0057-06 Washington University 660 South Euclid Avenue St. Louis, MO 63110
Southwest Tower Room 622 (office)
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Peer-reviewed Manuscripts
Genomic Landscape of TP53-Mutated Myeloid Malignancies
Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Srivatsan SN, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Link DC
medRxiv 2023 Jan 11:2023011023284322
Clonal Hematopoiesis and Risk of Incident Lung Cancer
Tian R, Wiley B, Liu J, Zong X, Truong B, Zhao S, Uddin MM, Niroula A, Miller CA, Mukherjee S, Heiden BT, Luo J, Puri V, Kozower BD, Walter MJ, Ding L, Link DC, Amos CI, Ebert BL, Govindan R, Natarajan P, Bolton KL, Cao Y
J Clin Oncol 2022 Dec 8:JCO2200857; [ahead of print]
Genomic Profiling for Clinical Decision Making in Myeloid Neoplasms and Acute Leukemia
Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Dohner H, Falini B, Garcia-Manero G, Haferlach T, Hellstrom-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Sole F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M
Blood 2022 Nov 24;140(21):2228-2247
IL-1beta Expression in Bone Marrow Dendritic Cells Is Induced by TLR2 Agonists and Regulates HSC Function
Li S, Yao JC, Oetjen KA, Krambs JR, Xia J, Zhang J, Schmidt AP, Helton NM, Fulton RS, Heath SE, Turnbull IR, Mbalaviele G, Ley TJ, Walter MJ, Link DC
Blood 2022 Oct 6;140(14):1607-1620
Proteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia
Kramer MH, Zhang Q, Sprung R, Day RB, Erdmann-Gilmore P, Li Y, Xu Z, Helton NM, George DR, Mi Y, Westervelt P, Payton JE, Ramakrishnan SM, Miller CA, Link DC, DiPersio JF, Walter MJ, Townsend RR, Ley TJ
Blood 2022 Sep 29;140(13):1533-1548
Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
Menssen AJ, Khanna A, Miller CA, Nonavinkere Srivatsan S, Chang GS, Shao J, Robinson J, O'Laughlin M, Fronick CC, Fulton RS, Brendel K, Heath SE, Saba R, Welch JS, Spencer DH, Payton JE, Westervelt P, DiPersio JF, Link DC, Schuelke MJ, Jacoby MA, Duncavage EJ, Ley TJ, Walter MJ
Blood Cancer Discov 2022 Jul 6;3(4):330-345
Toll-Like Receptor and Cytokine Expression Throughout the Bone Marrow Differs Between Patients With Low- and High-Risk Myelodysplastic Syndromes
Paracatu LC, Monlish DA, Greenberg ZJ, Fisher DAC, Walter MJ, Oh ST, Schuettpelz LG
Exp Hematol 2022 Jun;110:47-59
Focal Disruption of DNA Methylation Dynamics at Enhancers in IDH-Mutant AML Cells
Wilson ER, Helton NM, Heath SE, Fulton RS, Payton JE, Welch JS, Walter MJ, Westervelt P, DiPersio JF, Link DC, Miller CA, Ley TJ, Spencer DH
Leukemia 2022 Apr;36(4):935-945
Failure to Detect Mutations in U2AF1 Due to Changes in the GRCh38 Reference Sequence
Miller CA, Walker JR, Jensen TL, Hooper WF, Fulton RS, Painter JS, Sekeres MA, Ley TJ, Spencer DH, Goll JB, Walter MJ
J Mol Diagn 2022 Mar;24(3):219-223
Immunosuppression and Outcomes in Adult Patients With De Novo Acute Myeloid Leukemia With Normal Karyotypes
Ferraro F, Miller CA, Christensen KA, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Kohlschmidt J, Eisfeld AK, Bloomfield CD, Ramakrishnan SM, Day RB, Wartman LD, Uy GL, Welch JS, Christopher MJ, Heath SE, Baty JD, Schuelke MJ, Payton JE, Spencer DH, Rettig MP, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ
Proc Natl Acad Sci U S A 2021 Dec 7;118(49):e2116427118
Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
Petti AA, Khan SM, Xu Z, Helton N, Fronick CC, Fulton R, Ramakrishnan SM, Nonavinkere Srivatsan S, Heath SE, Westervelt P, Payton JE, Walter MJ, Link DC, DiPersio J, Miller C, Ley TJ
Blood Cancer Discov 2022 Jan;3(1):32-49
U2af1 Is a Haplo-Essential Gene Required for Hematopoietic Cancer Cell Survival in Mice
Wadugu BA, Nonavinkere Srivatsan S, Heard A, Alberti MO, Ndonwi M, Liu J, Grieb S, Bradley J, Shao J, Ahmed T, Shirai CL, Khanna A, Fei DL, Miller CA, Graubert TA, Walter MJ
J Clin Invest 2021 Nov 1;131(21)
Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations
Cheruiyot A, Li S, Nonavinkere Srivatsan S, Ahmed T, Chen Y, Lemacon DS, Li Y, Yang Z, Wadugu BA, Warner WA, Pruett-Miller SM, Obeng EA, Link DC, He D, Xiao F, Wang X, Bailis JM, Walter MJ, You Z
Cancer Res 2021 Sep 1;81(17):4499-4513
Mutant U2AF1-Induced Alternative Splicing of H2afy (MacroH2A1) Regulates B-Lymphopoiesis in Mice
Kim SP, Srivatsan SN, Chavez M, Shirai CL, White BS, Ahmed T, Alberti MO, Shao J, Nunley R, White LS, Bednarski J, Pehrson JR, Walter MJ
Cell Rep 2021 Aug 31;36(9):109626
A Synthetic Small Molecule Stalls Pre-mRNA Splicing by Promoting an Early-Stage U2AF2-RNA Complex
Chatrikhi R, Feeney CF, Pulvino MJ, Alachouzos G, MacRae AJ, Falls Z, Rai S, Brennessel WW, Jenkins JL, Walter MJ, Graubert TA, Samudrala R, Jurica MS, Frontier AJ, Kielkopf CL
Cell Chem Biol 2021 Aug 19;28(8):1145-1157
Bam-Readcount -- Rapid Generation of Basepair-Resolution Sequence Metrics
Khanna A, Larson DE, Srivatsan SN, Mosior M, Abbott TE, Kiwala S, Ley TJ, Duncavage EJ, Walter MJ, Walker JR, Griffith OL, Griffith M, Miller CA
ArXiv 2021 Jul 27:
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers
Duncavage EJ, Schroeder MC, O'Laughlin M, Wilson R, MacMillan S, Bohannon A, Kruchowski S, Garza J, Du F, Hughes AEO, Robinson J, Hughes E, Heath SE, Baty JD, Neidich J, Christopher MJ, Jacoby MA, Uy GL, Fulton RS, Miller CA, Payton JE, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Spencer DH
N Engl J Med 2021 Mar 11;384(10):924-935
Haploinsufficiency of Multiple del(5q) Genes Induce B Cell Abnormalities in Mice
Liu T, Ahmed T, Krysiak K, Shirai CL, Shao J, Nunley R, Bucala R, McKenzie A, Ndonwi M, Walter MJ
Leuk Res 2020 Sep;96:106428
SF3B1-Mutant MDS as a Distinct Disease Subtype: A Proposal From the International Working Group for the Prognosis of MDS
Malcovati L, Stevenson K, Papaemmanuil E, Neuberg D, Bejar R, Boultwood J, Bowen DT, Campbell PJ, Ebert BL, Fenaux P, Haferlach T, Heuser M, Jansen JH, Komrokji RS, Maciejewski JP, Walter MJ, Fontenay M, Garcia-Manero G, Graubert TA, Karsan A, Meggendorfer M, Pellagatti A, Sallman DA, Savona MR, Sekeres MA, Steensma DP, Tauro S, Thol F, Vyas P, Van de Loosdrecht AA, Haase D, Tuchler H, Greenberg PL, Ogawa S, Hellstrom-Lindberg E, Cazzola M
Blood 2020 Jul 9;136(2):157-170
The National MDS Natural History Study: Design of an Integrated Data and Sample Biorepository to Promote Research Studies in Myelodysplastic Syndromes
Sekeres MA, Gore SD, Stablein DM, DiFronzo N, Abel GA, DeZern AE, Troy JD, Rollison DE, Thomas JW, Waclawiw MA, Liu JJ, Al Baghdadi T, Walter MJ, Bejar R, Gorak EJ, Starczynowski DT, Foran JM, Cerhan JR, Moscinski LC, Komrokji RS, Deeg HJ, Epling-Burnette PK
Leuk Lymphoma 2019 Dec;60(13):3161-3171
Myelodysplastic Syndrome-Associated Spliceosome Gene Mutations Enhance Innate Immune Signaling
Pollyea DA, Harris C, Rabe JL, Hedin BR, De Arras L, Katz S, Wheeler E, Bejar R, Walter MJ, Jordan CT, Pietras EM, Alper S
Haematologica 2019 Sep;104(9):e388-e392
TP53 Mutation Status Divides Myelodysplastic Syndromes With Complex Karyotypes Into Distinct Prognostic Subgroups
Haase D, Stevenson KE, Neuberg D, Maciejewski JP, Nazha A, Sekeres MA, Ebert BL, Garcia-Manero G, Haferlach C, Haferlach T, Kern W, Ogawa S, Nagata Y, Yoshida K, Graubert TA, Walter MJ, List AF, Komrokji RS, Padron E, Sallman D, Papaemmanuil E, Campbell PJ, Savona MR, Seegmiller A, Ades L, Fenaux P, Shih LY, Bowen D, Groves MJ, Tauro S, Fontenay M, Kosmider O, Bar-Natan M, Steensma D, Stone R, Heuser M, Thol F, Cazzola M, Malcovati L, Karsan A, Ganster C, Hellstrom-Lindberg E, Boultwood J, Pellagatti A, Santini V, Quek L, Vyas P, Tuchler H, Greenberg PL, Bejar R International Working Group for MDS Molecular Prognostic Committee
Leukemia 2019 Jul;33(7):1747-1758
Immune Escape of Relapsed AML Cells After Allogeneic Transplantation
Christopher MJ, Petti AA, Rettig MP, Miller CA, Chendamarai E, Duncavage EJ, Klco JM, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Wilson RK, Wartman LD, Welch JS, Heath SE, Baty JD, Payton JE, Graubert TA, Link DC, Walter MJ, Westervelt P, Ley TJ, DiPersio JF
N Engl J Med 2018 Dec 13;379(24):2330-2341
Mutation Clearance After Transplantation for Myelodysplastic Syndrome
Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ
N Engl J Med 2018 Sep 13;379(11):1028-1041
Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes
Nguyen HD, Leong WY, Li W, Reddy PNG, Sullivan JD, Walter MJ, Zou L, Graubert TA
Cancer Res 2018 Sep 15;78(18):5363-5374
Discriminating a Common Somatic ASXL1 Mutation (C.1934dup; P.G646Wfs*12) From Artifact in Myeloid Malignancies Using NGS
Alberti MO, Srivatsan SN, Shao J, McNulty SN, Chang GS, Miller CA, Dunlap JB, Yang F, Press RD, Gao Q, Ding L, Heusel JW, Duncavage EJ, Walter MJ
Leukemia 2018 Aug;32(8):1874-1878
Germ Line Tissues for Optimal Detection of Somatic Variants in Myelodysplastic Syndromes
Padron E, Ball MC, Teer JK, Painter JS, Yoder SJ, Zhang C, Zhang L, Moscinski LC, Rollison DE, Gore SD, Bejar R, Walter MJ, Sekeres MA, Komrokji RS, Epling-Burnette PK
Blood 2018 May 24;131(21):2402-2405
Systematic Analysis of Splice-Site-Creating Mutations in Cancer
Jayasinghe RG, Cao S, Gao Q, Wendl MC, Vo NS, Reynolds SM, Zhao Y, Climente-Gonzalez H, Chai S, Wang F, Varghese R, Huang M, Liang WW, Wyczalkowski MA, Sengupta S, Li Z, Payne SH, Fenyo D, Miner JH, Walter MJ, Vincent B, Eyras E, Chen K, Shmulevich I, Chen F, Ding L Cancer Genome Atlas Research Network
Cell Rep 2018 Apr 3;23(1):270-281e3
Subclones Dominate at MDS Progression Following Allogeneic Hematopoietic Cell Transplant
Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
JCI Insight 2018 Mar 8;3(5)
Loss of Toll-Like Receptor 2 Results in Accelerated Leukemogenesis in the NUP98-HOXD13 Mouse Model of MDS
Monlish DA, Bhatt ST, Duncavage EJ, Greenberg ZJ, Keller JL, Romine MP, Yang W, Aplan PD, Walter MJ, Schuettpelz LG
Blood 2018 Mar 1;131(9):1032-1035
Cellular Stressors Contribute to the Expansion of Hematopoietic Clones of Varying Leukemic Potential
Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC
Nat Commun 2018 Jan 31;9(1):455
Knockdown of HSPA9 Induces TP53-Dependent Apoptosis in Human Hematopoietic Progenitor Cells
Liu T, Krysiak K, Shirai CL, Kim S, Shao J, Ndonwi M, Walter MJ
PLoS One 2017 Feb 8;12(2):e0170470
Mutational Landscape and Response Are Conserved in Peripheral Blood of AML and MDS Patients During Decitabine Therapy
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood 2017 Mar 9;129(10):1397-1401
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell 2017 Feb 23;168(5):801-816
Mutant U2AF1-Expressing Cells Are Sensitive to Pharmacological Modulation of the Spliceosome
Shirai CL, White BS, Tripathi M, Tapia R, Ley JN, Ndonwi M, Kim S, Shao J, Carver A, Saez B, Fulton RS, Fronick C, O'Laughlin M, Lagisetti C, Webb TR, Graubert TA, Walter MJ
Nat Commun 2017 Jan 9;8:14060
Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
Leukemia 2017 Apr;31(4):872-881
TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med 2016 Nov 24;375(21):2023-2036
Targeted Sequencing Informs the Evaluation of Normal Karyotype Cytopenic Patients for Low-Grade Myelodysplastic Syndrome
Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
Leukemia 2016 Dec;30(12):2422-2426
Comprehensive Genomic Analysis Reveals FLT3 Activation and a Therapeutic Strategy for a Patient With Relapsed Adult B-Lymphoblastic Leukemia
Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
Exp Hematol 2016 Jul;44(7):603-13
Rapid Expansion of Preexisting Nonleukemic Hematopoietic Clones Frequently Follows Induction Therapy for De Novo AML
Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
Blood 2016 Feb 18;127(7):893-7
Patterns and Functional Implications of Rare Germline Variants Across 12 Cancer Types
Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, DiPersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L
Nat Commun 2015 Dec 22;6:10086
Genomic Analysis of Germ Line and Somatic Variants in Familial Myelodysplasia/Acute Myeloid Leukemia
Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
Blood 2015 Nov 26;126(22):2484-90
Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA 2015 Aug 25;314(8):811-822
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing in Vivo
Shirai CL, Ley JN, White BS, Kim S, Tibbitts J, Shao J, Ndonwi M, Wadugu B, Duncavage EJ, Okeyo-Owuor T, Liu T, Griffith M, McGrath S, Magrini V, Fulton RS, Fronick C, O'Laughlin M, Graubert TA, Walter MJ
Cancer Cell 2015 May 11;27(5):631-43
Reduced Levels of Hspa9 Attenuate Stat5 Activation in Mouse B Cells
Krysiak K, Tibbitts JF, Shao J, Liu T, Ndonwi M, Walter MJ
Exp Hematol 2015 Apr;43(4):319-30e10
Role of TP53 Mutations in the Origin and Evolution of Therapy-Related Acute Myeloid Leukaemia
Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
Nature 2015 Feb 26;518(7540):552-555
U2AF1 Mutations Alter Sequence Specificity of Pre-mRNA Binding and Splicing
Okeyo-Owuor T, White BS, Chatrikhi R, Mohan DR, Kim S, Griffith M, Ding L, Ketkar-Kulkarni S, Hundal J, Laird KM, Kielkopf CL, Ley TJ, Walter MJ, Graubert TA
Leukemia 2015 Apr;29(4):909-917
Caspase-9 Is Required for Normal Hematopoietic Development and Protection From Alkylator-Induced DNA Damage in Mice
Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA
Blood 2014 Dec 18;124(26):3887-95
Age-Related Mutations Associated With Clonal Hematopoietic Expansion and Malignancies
Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, DiPersio JF, Chen F, Wilson RK, Ley TJ, Ding L
Nat Med 2014 Dec;20(12):1472-1478
Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing
Hughes AE, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, DiPersio JF, Mardis ER, Wilson RK, Ley TJ, Walter MJ, Graubert TA
PLoS Genet 2014 Jul 10;10(7):e1004462
SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution
Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L
PLoS Comput Biol 2014 Aug 7;10(8):e1003665
Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
Cancer Cell 2014 Mar 17;25(3):379-92
The DNA Double-Strand Break Response Is Abnormal in Myeloblasts From Patients With Therapy-Related Acute Myeloid Leukemia
Jacoby MA, De Jesus Pizarro RE, Shao J, Koboldt DC, Fulton RS, Zhou G, Wilson RK, Walter MJ
Leukemia 2014 Jun;28(6):1242-51
Mutational Landscape and Significance Across 12 Major Cancer Types
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, Leiserson MD, Miller CA, Welch JS, Walter MJ, Wendl MC, Ley TJ, Wilson RK, Raphael BJ, Ding L
Nature 2013 Oct 17;502(7471):333-9
Acquired Copy Number Alterations of miRNA Genes in Acute Myeloid Leukemia Are Uncommon
Ramsingh G, Jacoby MA, Shao J, De Jesus Pizzaro RE, Shen D, Trissal M, Getz AH, Ley TJ, Walter MJ, Link DC
Blood 2013 Oct 10;122(15):e44-e51
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G, Alonso S, Ayala B, Baboud J, Backus M, Barletta SP, Berton DL, Chu AL, Girshik S, Jensen MA, Kahn A, Kothiyal P, Nicholls MC, Pihl TD, Pot DA, Raman R, Sanbhadti RN, Snyder EE, Srinivasan D, Walton J, Wan Y, Wang Z, Issa JP, Le Beau M, Carroll M, Kantarjian H, Kornblau S, Bootwalla MS, Lai PH, Shen H, Van Den Berg DJ, Weisenberger DJ, Link DC, Walter MJ, Ozenberger BA, Mardis ER, Westervelt P, Graubert TA, DiPersio JF, Wilson RK
N Engl J Med 2013 May 30;368(22):2059-74
Clonal Diversity of Recurrently Mutated Genes in Myelodysplastic Syndromes Walter MJ*, Shen D*, Shao J*, Ding L, White BS, Kandoth C, Miller CA, Niu B, McLellan MD, Dees ND, Fulton R, Elliot K, Heath S, Grillot M, Westervelt P, Link DC, DiPersio JF, Mardis E, Ley TJ, Wilson RK, Graubert TA (*contributed equally)
Leukemia 2013 Jun;27(6):1275-82
The Origin and Evolution of Mutations in Acute Myeloid Leukemia
Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, Dipersio JF, Ding L, Mardis ER, Wilson RK
Cell 2012 Jul 20;150(2):264-78
Clonal Evolution in Relapsed Acute Myeloid Leukaemia Revealed by Whole-Genome Sequencing
Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling DJ, Fulton RS, Fulton LL, Chen K, Schmidt H, Kalicki-Veizer J, Magrini VJ, Cook L, McGrath SD, Vickery TL, Wendl MC, Heath S, Watson MA, Link DC, Tomasson MH, Shannon WD, Payton JE, Kulkarni S, Westervelt P, Walter MJ, Graubert TA, Mardis ER, Wilson RK, DiPersio JF
Nature 2012 Jan 11;481(7382):506-10
Clonal Architecture of Secondary Acute Myeloid Leukemia Walter MJ*, Shen D*, Ding L*, Shao J, Koboldt DC, Chen K, Larson DE, McLellan MD, Dooling D, Abbott R, Fulton R, Magrini V, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Fan X, Grillot M, Witowski S, Heath S, Frater JL, Eades W, Tomasson M, Westervelt P, DiPersio JF, Link DC, Mardis ER, Ley TJ, Wilson RK, Graubert TA (*contributed equally)
N Engl J Med 2012 Mar 22;366(12):1090-8
Recurrent Mutations in the U2AF1 Splicing Factor in Myelodysplastic Syndromes
Graubert TA, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris CC, Koboldt DC, Larson DE, McLellan MD, Dooling DJ, Abbott RM, Fulton RS, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Grillot M, Baty J, Heath S, Frater JL, Nasim T, Link DC, Tomasson MH, Westervelt P, Dipersio JF, Mardis ER, Ley TJ, Wilson RK, Walter MJ
Nat Genet 2011 Dec 11;44(1):53-7
Identification of a Novel TP53 Cancer Susceptibility Mutation Through Whole-Genome Sequencing of a Patient With Therapy-Related AML
Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, Delehaunty KD, Fronick CC, Appelbaum EL, Schmidt H, Abbott R, O'Laughlin M, Chen K, McLellan MD, Varghese N, Nagarajan R, Heath S, Graubert TA, Ding L, Ley TJ, Zambetti GP, Wilson RK, Mardis ER
JAMA 2011 Apr 20;305(15):1568-1576
Recurrent DNMT3A Mutations in Patients With Myelodysplastic Syndromes Walter MJ*, Ding L*, Shen D*, Shao J, Grillot M, McLellan M, Fulton R, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Kandoth C, Baty J, Westervelt P, Dipersio JF, Mardis ER, Wilson RK, Ley TJ, Graubert TA (*contributed equally)
Leukemia 2011 Jul;25(7):1153-8
Knockdown of Hspa9, a del(5q31.2) Gene, Results in a Decrease in Hematopoietic Progenitors in Mice
Chen TH, Kambal A, Krysiak K, Walshauser MA, Raju G, Tibbitts JF, Walter MJ
Blood 2011 Feb 3;117(5):1530-9
DNMT3A Mutations in Acute Myeloid Leukemia
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
N Engl J Med 2010 Dec 16;363(25):2424-33
Limited Engraftment of Low-Risk Myelodysplastic Syndrome Cells in NOD/SCID Gamma-C Chain Knockout Mice
Martin MG, Welch JS, Uy GL, Fehniger TA, Kulkarni S, Duncavage EJ, Walter MJ
Leukemia 2010 Sep;24(9):1662-4
POU4F1 Is Associated With t(8;21) Acute Myeloid Leukemia and Contributes Directly to Its Unique Transcriptional Signature
Fortier JM, Payton JE, Cahan P, Ley TJ, Walter MJ, Graubert TA
Leukemia 2010 May;24(5):950-7
Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes Walter MJ*^, Payton JE*, Ries RE*, Shannon WD, Deshmukh H, Zhao Y, Baty J, Heath S, Westervelt P, Watson MA, Tomasson MH, Nagarajan R, O'Gara BP, Bloomfield CD, Mrozek K, Selzer RR, Richmond TA, Kitzman J, Geoghegan J, Eis PS, Maupin R, Fulton RS, McLellan M, Wilson RK, Mardis ER, Link DC, Graubert TA, DiPersio JF, Ley TJ (*contributed equally; ^corresponding author)
Proc Natl Acad Sci U S A 2009 Aug 4;106(31):12950-5
Therapy Related Acute Myeloid Leukemia in Breast Cancer Survivors, a Population-Based Study
Martin MG, Welch JS, Luo J, Ellis MJ, Graubert TA, Walter MJ
Breast Cancer Res Treat 2009 Dec;118(3):593-8
Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, Reed JS, Robinson JS, Wylie T, Smith SM, Carmichael L, Eldred JM, Harris CC, Walker J, Peck JB, Du F, Dukes AF, Sanderson GE, Brummett AM, Clark E, McMichael JF, Meyer RJ, Schindler JK, Pohl CS, Wallis JW, Shi X, Lin L, Schmidt H, Tang Y, Haipek C, Wiechert ME, Ivy JV, Kalicki J, Elliott G, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson MA, Baty J, Heath S, Shannon WD, Nagarajan R, Link DC, Walter MJ, Graubert TA, DiPersio JF, Wilson RK, Ley TJ
N Engl J Med 2009 Sep 10;361(11):1058-66
Integrated Genomic Analysis Implicates Haploinsufficiency of Multiple Chromosome 5q31.2 Genes in De Novo Myelodysplastic Syndromes Pathogenesis
Graubert TA, Payton MA, Shao J, Walgren RA, Monahan RS, Frater JL, Walshauser MA, Martin MG, Kasai Y, Walter MJ
PLoS ONE 2009;4(2):e4583
Somatic Mutations and Germline Sequence Variants in the Expressed Tyrosine Kinase Genes of Patients With De Novo Acute Myeloid Leukemia
Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont D, McLellan MD, Payton JE, Westervelt P, Dipersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ
Blood 2008 May 1;111(9):4797-808
DNA Sequencing of a Cytogenetically Normal Acute Myeloid Leukaemia Genome
Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, Smith S, Hawkins A, Abbott S, Locke D, Hillier LW, Miner T, Fulton L, Magrini V, Wylie T, Glasscock J, Conyers J, Sander N, Shi X, Osborne JR, Minx P, Gordon D, Chinwalla A, Zhao Y, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson M, Baty J, Ivanovich J, Heath S, Shannon WD, Nagarajan R, Walter MJ, Link DC, Graubert TA, DiPersio JF, Wilson RK
Nature 2008 Nov 6;456(7218):66-72
Expression of a Bcr-1 Isoform of RARalpha-PML Does Not Affect the Penetrance of Acute Promyelocytic Leukemia or the Acquisition of an Interstitial Deletion on Mouse Chromosome 2 Walter MJ, Ries RE, Armstrong JR, Park JS, Mardis ER, Ley TJ
Blood 2007 Feb 1;109(3):1237-40
Reduced PU.1 Expression Causes Myeloid Progenitor Expansion and Increased Leukemia Penetrance in Mice Expressing PML-RARalpha Walter MJ, Park JS, Ries RE, Lau SK, McLellan M, Jaeger S, Wilson RK, Mardis ER, Ley TJ
Proc Natl Acad Sci U S A 2005 Aug 30;102(35):12513-8
Expression Profiling of Murine Acute Promyelocytic Leukemia Cells Reveals Multiple Model-Dependent Progression Signatures Walter MJ, Park JS, Lau SK, Li X, Lane AA, Nagarajan R, Shannon WD, Ley TJ
Mol Cell Biol 2004 Dec;24(24):10882-93
A Pilot Study of High-Throughput, Sequence-Based Mutational Profiling of Primary Human Acute Myeloid Leukemia Cell Genomes
Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, Heath S, Vardiman JW, Caligiuri MA, Bloomfield CD, Milbrandt JD, Mardis ER, Wilson RK
Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14275-80
Adaptive Immunity Cooperates With Liposomal All-Trans-Retinoic Acid (ATRA) to Facilitate Long-Term Molecular Remissions in Mice With Acute Promyelocytic Leukemia
Westervelt P, Pollock JL, Oldfather KM, Walter MJ, Ma MK, Williams A, DiPersio JF, Ley TJ
Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9468-73
Detection of HTLV-I in Peripheral Blood Lymphocytes From Patients With Chronic HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis and Asymptomatic Carriers by PCR-In Situ Hybridization Walter MJ, Lehky TJ, Levin MC, Fox CH, Jacobson S
J Biomed Sci 1997 Jan;4(1):54-60
PCR-In Situ Hybridization Detection of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) Tax Proviral DNA in Peripheral Blood Lymphocytes of Patients With HTLV-1-Associated Neurologic Disease
Levin MC, Fox RJ, Lehky T, Walter M, Fox CH, Flerlage N, Bamford R, Jacobson S
J Virol 1996 Feb;70(2):924-33
Effects of Localized Injections of Neuropeptide Y Antibody on Motor Activity and Other Behaviors Walter MJ, Scherrer JF, Flood JF, Morley JE
Peptides 1994;15(4):607-13
Wound Healing and Nutritional State in Patients Undergoing Reconstruction of Chronic Wounds Walter MJ, Bartell TH, Paletta CE, Herrmann V
Wounds 1994;6(4):128-131
Implications of Tumor Clonal Heterogeneity in the Era of Next-Generation Sequencing
Jacoby MA, Duncavage EJ, Walter MJ
Trends Cancer 2015 Dec;1(4):231-241
Next-Generation Sequencing of Cancer Genomes: Back to the Future Walter MJ, Graubert TA, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
Per Med 2009 Nov 1;6(6):653
del(5q): Gene Dose Matters Walter MJ
Blood 2007;110(2):473-4