Oncology Division
Alphabetical list (active faculty):   
David H. Spencer

David H. Spencer, MD, PhD

Associate Professor

Department of Medicine

Oncology Division

Stem Cell Biology

Research Interests

  • AML
  • Cancer
  • Epigenetics
  • DNA methylation
  • Genomics


  • 314-273-0739 (office)
  • 314-362-9333 (fax)
  • Division of Oncology
    Campus Box 8056
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 619 Southwest Tower (office)


Research in the Spencer lab is a combination of experimental and computational science that is focused on the common theme of the genetics, genomics, and epigenetics of acute myeloid leukemia. We have specific expertise in DNA methylation, 3D genome architecture, and HOX gene expression and regulation in AML, although we are broadly interested in epigenetics and gene regulation in cancer. We also have extensive experience using genomic technologies to make observations in primary human samples to understand fundamental mechanisms of cancer genomics.

We use a range of experimental systems and techniques in our lab, including:

  • Whole-exome sequencing, whole-genome sequencing, error-corrected amplicon sequencing
  • Long read sequencing using Oxford Nanopore and PacBio Hifi platforms
  • ChIP-seq, RNA-seq, ATAC-seq, CUT&Run, CUT&Tag
  • in situ HiC, capture-C, HiChIP, PLAC-seq
  • Whole-genome bisulfite sequencing
  • CRISPR/Cas9 genome editing, CRISPRi epigenetic editing
  • CRE-seq massively parallel reporter assays
  • Single cell technologies
  • Human cell lines, human pluripotent stem cells, including NIH-approved embryonic stem cells and induced pluripotent stem (iPS) cells
  • Primary human AML samples
  • Mouse models

HOXA model