Address:
Division of Oncology
Mail Stop 8007-0029-11
Washington University
660 South Euclid Avenue
St. Louis, MO 63110
11th Floor Mid Campus Center (office)
Admin:
Shannon Dobbs
dobbss@wustl.edu
- Stem-cell transplantation
- Leukemia
My research is focused on the development of new agents and treatment approaches for patients with myelodysplastic syndromes and acute leukemias. I currently serve as Medical Director for Clinical Research within the Division of Oncology and serve as the institutional principal investigator for industry and cooperative group sponsored studies for acute leukemias.
My primary research focus is on modulating tumor microenvironment interactions to improve therapy for acute leukemia. In preclinical models, disrupting key molecules such as CXCR4 and VLA-4 which mediate tumor microenvironment interactions increase the sensitivity of tumor cells to chemotherapy and have translated these studies into clinical trials. I am leading an investigator initiated study of BL8040 in combination with chemotherapy for patients with relapsed acute lymphoblastic leukemia. I am also currently leading the Alliance for Clinical Trials in Oncology study for older adults with de novo AML which will test an E-selectin antagonist, GMI-1271, in combination with conventional daunorubicin plus cytarabine chemotherapy.
Finally, I am also interested in the use of next generation sequencing technologies to measure disease response in myelodsysplastic syndromes and acute myeloid leukemia. We have demonstrated that can identify and track malignant clones during therapy with hypomethylating agents and may be an alternative measure of antitumor activity to supplement traditional response criteria which are based primarily on bone marrow morphology. These next generation sequencing approaches are being tested in the context of larger randomized studies being conducted in AML.
Biosketch
Education
- 2001-1996: MD/MA in Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO
- 1996-1992: BA in Chemistry and Biological Sciences (magna cum laude), Cornell University, Ithaca, NY
Post-Graduate Training
- 2007-2003: Fellow, Divisions of Hematology and Oncology, Department of Medicine, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, MO
- 2003-2001: Resident Physician, Department of Medicine, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, MO
Academic Positions
- present-2020: Professor of Medicine, Division of Oncology, Section of BMT & Leukemia, Washington University School of Medicine, St. Louis, MO
- present-2014: Medical Director for Clinical Research, Division of Oncology, Washington University School of Medicine, St. Louis, MO
- 2020-2014: Associate Professor of Medicine, Division of Oncology, Section of BMT & Leukemia, Washington University School of Medicine, St. Louis, MO
- 2014-2007: Assistant Professor of Medicine, Division of Oncology, Section of BMT & Leukemia, Washington University School of Medicine, St. Louis, MO
University & Hospital Appointments & Committees
- 2015-2012: Medical Director for Clinical Research, Section of BMT & Leukemia
- 2012-2010: Protocol Review and Monitoring Committee, Siteman Cancer Center
Board Certification
- 2008: Hematology
- 2007: Medical Oncology
- 2004: Internal Medicine
Honors & Awards
- 2022-2013: Best Doctors in America
- 2011: Cancer and Leukemia Group B Clinical Scholar Award
- 2010-2008: American Society of Hematology Scholar Award in Clinical / Translational Research
- 2006: American Society of Hematology Clinical Research Training Institute
- 2005: Siteman Cancer Center Research Development Fellowship
- 2004: American Society of Hematology Travel Award
- 2001-1999: Howard Hughes Medical Institute Continued Support for Completion of Medical Studies
- 1999-1998: Howard Hughes Medical Institute Medical Student Research Fellowship
- 1996: Phi Beta Kappa
- 1995: Cornell Hughes Scholar Research Program
Editorial Responsibilities
- 2022: NCI Review Panel: Loan Repayment Program (LRP-L30) ZCA1 PCRB-A (A1)
- 2021: NCI Review Panel: Special Emphasis Panel ZCA1 RPRB-N (M1) S – NCI SPORE (P50) Review II
- 2021: NCI Review Panel: Special Emphasis Panel ZRG1 F09B-Z (20) L – Fellowships: Oncology
- 2020: NIH/NCI: Review Panel: Special Emphasis Panel ZCA1 RPRB-N (M1)
- 2019-2015: Reviewer, Siteman Cancer Center Investment Program
- 2019-2012: American Society of Hematology Scholar Award, Clinical Study Section
- 2017: NIH/NCI: Review panel: Special Emphasis Panel ZCA1 TCRB-J
- 2015, 2013: NIH/NHLBI: Review panel Special Emphasis Panel/Scientific Review Group ZHL1CSR-I
- 2010, 2008: American Society of Hematology Abstract Reviewer, Acute myeloid leukemia – Therapy
National Scientific Panels
- present-2021: NCI Leukemia Steering Committee
- present-2019: Co-Chair, Older Adult Clinical Basket for MyeloMATCH, NCI Precision Medicine Initiative in Myeloid Malignancies
- present-2014: Special Government Employee, Oncologic Drugs Advisory Committee, Food and Drug Administration, US Department of Health and Human Services
- present-2007: Alliance for Clinical Trials in Oncology / Cancer and Leukemia Group B
- present-2021: Co-Chair, Leukemia Committee
- present-2015: Ad hoc Auditor
- present-2009: Member, Leukemia Committee
- 2019-2016: Co-Chair, Young Investigator Committee
Professional Societies & Organizations
- present-2010: Center for International Blood and Marrow Transplant Research, Acute Leukemia Working Committee
- present-2010: National Comprehensive Cancer Center Network, Acute Lymphoblastic Leukemia Guideline Panel
- present-2004: American Society for Blood and Marrow Transplantation
- present-2003: American Society of Hematology
- present-2013: Consult a Colleague, Acute Leukemia
- present-2003: American Society of Clinical Oncology