Brian A. Van Tine, MD, PhD

Brian A. Van Tine, MD, PhD

Professor

Address:
Division of Oncology
Mail Stop 8076-0041-03
Washington University
660 South Euclid Avenue
St. Louis, MO 63110

Room 3302, Couch Biomedical Research Building (office)

Admin:
Terrie Stald
tstald@wustl.edu

Clinical Interests
  • Soft tissue and bone sarcomas
Research Interests
  • Human-in-mouse sarcoma models
  • Amino acid deprivation therapies
  • Metabolic deficiencies in sarcoma
Research

Sarcomas are a rare group of over 100 types of tumors of mesenchymal origin that can be divided into 2 categories: soft tissue sarcomas and bone sarcomas. Our main objective is to delineate the molecular and genetic events underlying sarcoma pathogenesis. We work to identify metabolic deficiencies in sarcoma that can be used as therapeutic opportunities. We also generate new models that reflect the disease in patients by establishing pedigreed xenografts in immuno-deficient mice and their corresponding cell lines. Additionally, we study argininosuccinate synthase 1 (ASS1), a biomarker that is lost and is a sign of poor prognosis for sarcoma. When ASS1 is not expressed, arginine becomes an essential amino acid that must be delivered by the diet. We are testing whether the ASS1-deficiency of sarcomas may be exploited using the arginine-lowering agent, PEGylated arginine deiminase (ADI-PEG20). We have shown that we can use arginine starvation to change the metabolic transporter profile on the surface of cells, thus allowing chemotherapy to work. We are presently working to better delineate the in vivo adaptation that occurs in tumors.

Biosketch

Education

  • 2005: MD, University of Alabama, Birmingham, AL
  • 2003: PhD, University of Alabama, Birmingham, AL
  • 1995: BS in Chemistry and BS in Biochemistry, University of Arizona, Tucson, AZ

Post-Graduate Training

  • 2011-2007: Oncology Fellowship, Barnes-Jewish Hospital, Washington University, St. Louis, MO
  • 2010-2009: Chief Fellow, Hematology and Oncology, Washington University, St. Louis, MO
  • 2007-2006: Internal Medicine Residency, Barnes-Jewish Hospital, Washington University, St. Louis, MO
  • 2006-2005: Internal Medicine Internship, Barnes-Jewish Hospital, Washington University, St. Louis, MO

Academic Positions

  • present-2021: Professor of Medicine, Division of Medical Oncology, Washington University, St. Louis, MO
  • present-2021: Professor of Pediatrics, Clinician, Washington University, St. Louis, MO
  • present-2011: Sarcoma Program Director, Division of Medical Oncology, Washington University, St. Louis, MO
  • 2021-2020: Associate Professor of Pediatrics, Clinician, Washington University, St. Louis, MO
  • 2021-2016: Associate Professor of Medicine, Division of Medical Oncology, Washington University, St. Louis, MO
  • 2016-2011: Assistant Professor of Medicine, Division of Medical Oncology, Washington University, St. Louis, MO

Appointments & Committees

  • present-2022: Permanent Member, NIH Mechanisms of Cancer Therapeutics-1 [MCT1] Study Section
  • present-2021: Ovarian Cancer Research Working Group, Washington University
  • present-2021: Co-Director, Center for Early Phase Therapeutics, Washington University
  • present-2021: Ad Hoc NIH Mechanisms of Cancer Therapeutics-1 [MCT1] Study Section
  • present-2021: Sarcoma Foundation of America Medical Advisory Board
  • present-2021: National Cancer Institute’s NCTN Core Correlative Sciences Committees (NCTN-CCSC)
  • present-2020: AACR Pediatric Cancer Research Grants Scientific Review Committee
  • present-2020: Pediatric Focus Group-Steering Committee, Siteman Cancer Center
  • present-2020: Co-Director, Adolescent and Young Adult Program, Washington University
  • present-2019: AACR Annual Meeting Clinical Trials Committee
  • present-2018: Co-Chair, Alliance Sarcoma Working Group
  • present-2018: Siteman Cancer Center Protocol Review and Monitoring Committee
  • present-2016: National Leiomyosarcoma Foundation Executive Committee
  • present-2015: SARC Developmental Therapeutics Committee
  • present-2015: Siteman Steering Committee for Solid Tumors
  • present-2014: Correlative Vice Chair, Alliance Developmental Therapeutics Committee
  • present-2014: NRG Sarcoma Committee
  • present-2010: Organizer and Moderator, Multidisciplinary Sarcoma Tumor Board, Washington University
  • 2021-2020: Chair, Midwest Sarcoma Trials Partnership
  • 2016: Siteman Cancer Center Genetics Program Committee
  • 2015: Co-Chair, AACR Basic Science of Sarcoma Meeting
  • 2013-2011: NCCN Panel of Soft Tissue Sarcoma

Board Certification

  • 2024-2014: Medical Oncology
  • 2019-2009: Internal Medicine

Honors & Awards

  • 2014: Presented the 2014 Rosenfeld Lecture for the Sarcoma Alliance for Research and Collaboration
  • 2011: 1st Place Poster “Loss of Taspase1 Abrogates HER2/neu Induced Breast Cancer”, Washington University in St. Louis Breast Cancer Symposium
  • 2011-2005: Physician Scientist Training Program, Washington University in St. Louis
  • 2003: Edward S. Reynolds Award for Investigative Pathology – National Research Day Forum, Galveston, TX
  • 2001: Student Award for excellent presentation at the 19th International Papillomavirus Conference, Florianopolis, Brazil
  • 2001: UAB Comprehensive Cancer Center Poster Competition – Second Place
  • 2001: UAB Medical Student Research Day – First Place
  • 2001: Dean’s Award for the Joint Health Sciences
  • 1998: Participant in the Cold Spring Harbor Laboratory Summer Course: Advanced In Situ and Immunohistochemistry
  • 1997: Howard Hughes Medical Institute Summer Student Program

Editorial Boards

  • present-2015: Journal of Orthopaedic Research
  • 2023-2021: Rare Tumors
  • 2023-2018: Journal of Clinical Oncology
  • 2022-2021: Clinical Cancer Research
  • 2019-2014: Annals of Oncology

Professional Societies

  • present-2018: European Society for Medical Oncology
  • present-2011: Connective Tissue Oncology Society
  • present-2011: American Academy of Cancer Research
  • present-2007: American Society for Clinical Oncology