Michael P. Rettig, PhD

Michael P. Rettig, PhD

Professor

Address:
Division of Oncology
Mail Stop 8007-0057-06
Washington University
660 South Euclid Avenue
St. Louis, MO 63110

636 Southwest Tower (office)
634 Southwest Tower (lab)

Research Interests
  • Graft-versus-host disease
  • Hematopoietic stem cell transplantation
  • Hematopoietic stem cell mobilization
Research

One focus of my research is to continue to develop and test whether the CD34-TK75/GCV suicide gene therapy approach can be used to separate the life-threatening development of graft-versus-host disease from the beneficial graft-versus-leukemia effect after allogeneic hematopoietic stem cell transplantation. A second major focus of my research is to study the biology of hematopoietic stem and leukemia cell mobilization. We utilize mouse models and human specimens to characterize the kinetics, magnitude, immunophenotype and functional properties of hematopoietic stem and leukemia cells mobilized by G-CSF, CXCR4 antagonists, VLA-4 inhibitors and their combinations. We are also actively investigating whether these different hematopoietic stem cell mobilizing regimens can sensitize leukemia cells to chemotherapy.

Profiles (publications)

Biosketch

Education

  • 2000: PhD in Chemistry, Purdue University, West Lafayette, IN
  • 1993: BS in Chemistry, Illinois State University, Normal, IL

Post-Graduate Training

  • 2003-2000: Postdoctoral Fellow, Washington University School of Medicine, St. Louis, MO

Academic Positions & Employment

  • present-2014: Assistant Professor, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, St. Louis, MO
  • 2014-2007: Research Assistant Professor, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, St. Louis, MO
  • 2007-2005: Research Instructor, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, St. Louis, MO
  • 2005-2003: Research Associate, Division of Oncology, Washington University School of Medicine, St. Louis, MO (Faculty Advisor: John F. DiPersio, MD, PhD)
  • 2003-2000: Postdoctoral Fellow, Division of Oncology, Washington University School of Medicine, St. Louis, MO (Faculty Advisor: John F. DiPersio, MD, PhD)
  • 2000-1993: Research Assistant, Department of Chemistry, Purdue University, West Lafayette, IN (Faculty Advisor: Philip S. Low, PhD)
  • 1993-1992: Undergraduate Research Assistant, Department of Chemistry, Illinois State University, Normal, IL (Faculty Advisor: Michael E. Kurz, PhD)
  • 1992: Summer Intern, Control Division, The Upjohn Company, Kalamazoo, MI
  • 1991-1988: Lab Technician, Environmental Contract Laboratory Division, Applied Research and Development Laboratory, Mt. Vernon, IL

Honors & Awards

  • 2005: Fellow Scholar Award, American Society of Hematology
  • 2001: Best Abstract Award, International Society of Hematotherapy & Graft Engineering, VIIth Annual Meeting, Quebec City, Canada
  • 1993: Summa Cum Laude, Illinois State University

Professional Societies

  • American Society of Hematology