Faculty
Oncology Division
Rettig.jpg

Michael P. Rettig, PhD

Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology

Research Interests

  • Graft-versus-host disease
  • Hematopoietic stem cell transplantation
  • Hematopoietic stem cell mobilization

Contact

  • 314-362-9560 (tel)
  • 314-362-9333 (fax)
  • 636 Southwest Tower (office)
  • 634 Southwest Tower (lab)
  • Division of Oncology
    Section of Stem Cell Biology
    Campus Box 8007
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Research

One focus of my research is to continue to develop and test whether the CD34-TK75/GCV suicide gene therapy approach can be used to separate the life-threatening development of graft-versus-host disease from the beneficial graft-versus-leukemia effect after allogeneic hematopoietic stem cell transplantation. A second major focus of my research is to study the biology of hematopoietic stem and leukemia cell mobilization. We utilize mouse models and human specimens to characterize the kinetics, magnitude, immunophenotype and functional properties of hematopoietic stem and leukemia cells mobilized by G-CSF, CXCR4 antagonists, VLA-4 inhibitors and their combinations. We are also actively investigating whether these different hematopoietic stem cell mobilizing regimens can sensitize leukemia cells to chemotherapy.