David H. Spencer, MD, PhD
Associate Professor
Department of Medicine
Oncology Division
Stem Cell Biology
Research Interests
- AML
- Cancer
- Epigenetics
- DNA methylation
- Genomics
Contact
- 314-273-0739 (office)
- 314-362-9333 (fax)
- dspencer@wustl.edu
- Division of Oncology
Campus Box 8056
Washington University
660 South Euclid Avenue
St. Louis, MO 63110
- Room 619 Southwest Tower (office)
- Spencer lab website
Original Articles
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Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing
Slade MJ, Ghasemi R, O'Laughlin M, Burton T, Fulton RS, Abel HJ, Duncavage EJ, Ley TJ, Jacoby MA, Spencer DH
JCO Precis Oncol 2023 Apr;7:e2200559
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KDM6B Protects T-ALL Cells From NOTCH1-Induced Oncogenic Stress
Issa N, Bjeije H, Wilson ER, Krishnan A, Dunuwille WMB, Parsons TM, Zhang CR, Han W, Young AL, Ren Z, Ge K, Wang ES, Weng AP, Cashen A, Spencer DH, Challen GA
Leukemia 2023 Apr;37(4):728-740
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Evaluation of Breast Implant-Associated Anaplastic Large Cell Lymphoma With Whole Exome and Genome Sequencing
Akkad N, Kodgule R, Duncavage EJ, Mehta-Shah N, Spencer DH, Watkins M, Shirai C, Myckatyn TM
Aesthet Surg J 2023 Feb 21;43(3):318-328
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Genomic Landscape of TP53-Mutated Myeloid Malignancies
Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Srivatsan SN, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Link DC
medRxiv 2023 Jan 11:2023011023284322
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Clinical Whole-Genome Sequencing in Cancer Diagnosis
Hou YC, Neidich JA, Duncavage EJ, Spencer DH, Schroeder MC
Hum Mutat 2022 Nov;43(11):1519-1530
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Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
Menssen AJ, Khanna A, Miller CA, Nonavinkere Srivatsan S, Chang GS, Shao J, Robinson J, O'Laughlin M, Fronick CC, Fulton RS, Brendel K, Heath SE, Saba R, Welch JS, Spencer DH, Payton JE, Westervelt P, DiPersio JF, Link DC, Schuelke MJ, Jacoby MA, Duncavage EJ, Ley TJ, Walter MJ
Blood Cancer Discov 2022 Jul 6;3(4):330-345
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Clonal Dynamics of Haematopoiesis Across the Human Lifespan
Mitchell E, Spencer Chapman M, Williams N, Dawson KJ, Mende N, Calderbank EF, Jung H, Mitchell T, Coorens THH, Spencer DH, Machado H, Lee-Six H, Davies M, Hayler D, Fabre MA, Mahbubani K, Abascal F, Cagan A, Vassiliou GS, Baxter J, Martincorena I, Stratton MR, Kent DG, Chatterjee K, Parsy KS, Green AR, Nangalia J, Laurenti E, Campbell PJ
Nature 2022 Jun;606(7913):343-350
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Hematopoietic Cell Transplantation Donor-Derived Memory-Like NK Cells Functionally Persist After Transfer Into Patients With Leukemia
Berrien-Elliott MM, Foltz JA, Russler-Germain DA, Neal CC, Tran J, Gang M, Wong P, Fisk B, Cubitt CC, Marin ND, Zhou AY, Jacobs MT, Foster M, Schappe T, McClain E, Kersting-Schadek S, Desai S, Pence P, Becker-Hapak M, Eisele J, Mosior M, Marsala L, Griffith OL, Griffith M, Khan SM, Spencer DH, DiPersio JF, Romee R, Uy GL, Abboud CN, Ghobadi A, Westervelt P, Stockerl-Goldstein K, Schroeder MA, Wan F, Lie WR, Soon-Shiong P, Petti AA, Cashen AF, Fehniger TA
Sci Transl Med 2022 Feb 23;14(633):eabm1375
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Failure to Detect Mutations in U2AF1 Due to Changes in the GRCh38 Reference Sequence
Miller CA, Walker JR, Jensen TL, Hooper WF, Fulton RS, Painter JS, Sekeres MA, Ley TJ, Spencer DH, Goll JB, Walter MJ
J Mol Diagn 2022 Mar;24(3):219-223
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Focal Disruption of DNA Methylation Dynamics at Enhancers in IDH-Mutant AML Cells
Wilson ER, Helton NM, Heath SE, Fulton RS, Payton JE, Welch JS, Walter MJ, Westervelt P, DiPersio JF, Link DC, Miller CA, Ley TJ, Spencer DH
Leukemia 2022 Apr;36(4):935-945
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Immunosuppression and Outcomes in Adult Patients With De Novo Acute Myeloid Leukemia With Normal Karyotypes
Ferraro F, Miller CA, Christensen KA, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Kohlschmidt J, Eisfeld AK, Bloomfield CD, Ramakrishnan SM, Day RB, Wartman LD, Uy GL, Welch JS, Christopher MJ, Heath SE, Baty JD, Schuelke MJ, Payton JE, Spencer DH, Rettig MP, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ
Proc Natl Acad Sci U S A 2021 Dec 7;118(49):e2116427118
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DNMT3A Overgrowth Syndrome Is Associated With the Development of Hematopoietic Malignancies in Children and Young Adults
Ferris MA, Smith AM, Heath SE, Duncavage EJ, Oberley M, Freyer D, Wynn R, Douzgou S, Maris JM, Reilly AF, Wu MD, Choo F, Fiets RB, Koene S, Spencer DH, Miller CA, Shinawi M, Ley TJ
Blood 2022 Jan 20;139(3):461-464
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Tumor Suppressor Function of WT1 in Acute Promyelocytic Leukemia
Christopher MJ, Katerndahl CDS, LeBlanc HR, Elmendorf TT, Basu V, Gang M, Menssen AJ, Spencer DH, Duncavage EJ, Ketkar S, Wartman LD, Ramakrishnan SM, Miller CA, Ley TJ
Haematologica 2022 Jan 1;107(1):342-346
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Heterozygous Variants of CLPB Are a Cause of Severe Congenital Neutropenia
Warren JT, Cupo RR, Wattanasirakul P, Spencer DH, Locke AE, Makaryan V, Bolyard AA, Kelley ML, Kingston NL, Shorter J, Bellanné-Chantelot C, Donadieu J, Dale DC, Link DC
Blood 2022 Feb 3;139(5):779-791
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Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia
Barnell EK, Newcomer KF, Skidmore ZL, Krysiak K, Anderson SR, Wartman LD, Oh ST, Welch JS, Stockerl-Goldstein KE, Vij R, Cashen AF, Pusic I, Westervelt P, Abboud CN, Ghobadi A, Uy GL, Schroeder MA, Dipersio JF, Politi MC, Spencer DH, Duncavage EJ, Ley TJ, Griffith M, Jacoby MA, Griffith OL
JCO Precis Oncol 2021 Jan 14;5:PO2000182
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Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers
Duncavage EJ, Schroeder MC, O'Laughlin M, Wilson R, MacMillan S, Bohannon A, Kruchowski S, Garza J, Du F, Hughes AEO, Robinson J, Hughes E, Heath SE, Baty JD, Neidich J, Christopher MJ, Jacoby MA, Uy GL, Fulton RS, Miller CA, Payton JE, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Spencer DH
N Engl J Med 2021 Mar 11;384(10):924-935
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Contribution of CTCF Binding to Transcriptional Activity at the HOXA Locus in NPM1-Mutant AML Cells
Ghasemi R, Struthers H, Wilson ER, Spencer DH
Leukemia 2021 Feb;35(2):404-416
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Remethylation of Dnmt3a (-/-) Hematopoietic Cells Is Associated With Partial Correction of Gene Dysregulation and Reduced Myeloid Skewing
Ketkar S, Verdoni AM, Smith AM, Bangert CV, Leight ER, Chen DY, Brune MK, Helton NM, Hoock M, George DR, Fronick C, Fulton RS, Ramakrishnan SM, Chang GS, Petti AA, Spencer DH, Miller CA, Ley TJ
Proc Natl Acad Sci U S A 2020 Feb 11;117(6):3123-3134
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Inflammatory Cytokines Promote Clonal Hematopoiesis With Specific Mutations in Ulcerative Colitis Patients
Zhang CRC, Nix D, Gregory M, Ciorba MA, Ostrander EL, Newberry RD, Spencer DH*, Challen GA* (*Shared authorship
Exp Hematol 2019 Dec;80:36-41e3
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Immunological Ignorance Is an Enabling Feature of the Oligo-Clonal T Cell Response to Melanoma Neoantigens
Linette GP, Becker-Hapak M, Skidmore ZL, Baroja ML, Xu C, Hundal J, Spencer DH, Fu W, Cummins C, Robnett M, Kaabinejadian S, Hildebrand WH, Magrini V, Demeter R, Krupnick AS, Griffith OL, Griffith M, Mardis ER, Carreno BM
Proc Natl Acad Sci U S A 2019 Nov 19;116(47):23662-23670
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Functional Characterization of Biallelic RTTN Variants Identified in an Infant With Microcephaly, Simplified Gyral Pattern, Pontocerebellar Hypoplasia, and Seizures
Wambach JA, Wegner DJ, Yang P, Shinawi M, Baldridge D, Betleja E, Shimony JS, Spencer D, Hackett BP, Andrews MV, Ferkol T, Dutcher SK, Mahjoub MR, Cole FS
Pediatr Res 2018 Sep;84(3):435-441
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DNMT3A(R882)-Associated Hypomethylation Patterns Are Maintained in Primary AML Xenografts, but Not in the DNMT3A(R882C) OCI-AML3 Leukemia Cell Line
Chen D, Christopher M, Helton NM, Ferguson I, Ley TJ, Spencer DH
Blood Cancer J 2018 Apr 4;8(4):38
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Expression Profiling of snoRNAs in Normal Hematopoiesis and AML
Warner WA*, Spencer DH*, Trissal M, White BS, Helton N, Ley TJ, Link DC (*Shared authorship)
Blood Adv 2018 Jan 23;2(2):151-163
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Comprehensive Discovery of Noncoding RNAs in Acute Myeloid Leukemia Cell Transcriptomes
Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Klco JM, Mardis ER, Ley TJ, Wilson RK, Maher CA
Exp Hematol 2017 Nov;55:19-33
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CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell 2017 Feb 23;168(5):801-816e13
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Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA 2015 Aug 25;314(8):811-22
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Epigenomic Analysis of the HOX Gene Loci Reveals Mechanisms That May Control Canonical Expression Patterns in AML and Normal Hematopoietic Cells
Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ
Leukemia 2015 Jun;29(6):1279-89
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The R882H DNMT3A Mutation Associated With AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers
Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ
Cancer Cell 2014 Apr 14;25(4):442-54
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Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
Klco JM*, Spencer DH*, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, DiPersio JF, Wilson RK, Ley TJ (*shared authorship)
Cancer Cell 2014 Mar 17;25(3):379-92
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Performance of Common Analysis Methods for Detecting Low-Frequency Single Nucleotide Variants in Targeted Next-Generation Sequence Data
Spencer DH, Tyagi M, Vallania F, Bredemeyer AJ, Pfeifer JD, Mitra RD, Duncavage EJ
J Mol Diagn 2014 Jan;16(1):75-88
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Validation of a Next-Generation Sequencing Assay for Clinical Molecular Oncology
Cottrell CE, Al-Kateb H, Bredemeyer AJ, Duncavage EJ, Spencer DH, Abel HJ, Lockwood CM, Hagemann IS, O'Guin SM, Burcea LC, Sawyer CS, Oschwald DM, Stratman JL, Sher DA, Johnson MR, Brown JT, Cliften PF, George B, McIntosh LD, Shrivastava S, Nguyen TT, Payton JE, Watson MA, Crosby SD, Head RD, Mitra RD, Nagarajan R, Kulkarni S, Seibert K, Virgin HW 4th, Milbrandt J, Pfeifer JD
J Mol Diagn 2014 Jan;16(1):89-105
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Comparison of Clinical Targeted Next-Generation Sequence Data From Formalin-Fixed and Fresh-Frozen Tissue Specimens
Spencer DH, Sehn JK, Abel HJ, Watson MA, Pfeifer JD, Duncavage EJ
J Mol Diagn 2013 Sep;15(5):623-33
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Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G
Cancer Genome Atlas Research Network
N Engl J Med 2013 May 30;368(22):2059-74
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Detection of FLT3 Internal Tandem Duplication in Targeted, Short-Read-Length, Next-Generation Sequencing Data
Spencer DH, Abel HJ, Lockwood CM, Payton JE, Szankasi P, Kelley TW, Kulkarni S, Pfeifer JD, Duncavage EJ
J Mol Diagn 2013 Jan;15(1):81-93
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Genomic Impact of Transient Low-Dose Decitabine Treatment on Primary AML Cells
Klco JM*, Spencer DH*, Lamprecht TL, Sarkaria SM, Wylie T, Magrini V, Hundal J, Walker J, Varghese N, Erdmann-Gilmore P, Lichti CF, Meyer MR, Townsend RR, Wilson RK, Mardis ER, Ley TJ (*shared authorship)
Blood 2013 Feb 28;121(9):1633-43
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Direct-To-Consumer Genetic Testing: Reliable or Risky?
Spencer DH, Lockwood C, Topol E, Evans JP, Green RC, Mansfield E, Tezak Z
Clin Chem 2011 Dec;57(12):1641-4
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Validation and Implementation of the GeneXpert MRSA/SA Blood Culture Assay in a Pediatric Setting
Spencer DH, Sellenriek P, Burnham CA
Am J Clin Pathol 2011 Nov;136(5):690-4
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Red Cell Transfusion Decreases Hemoglobin A1c in Patients With Diabetes
Spencer DH, Grossman BJ, Scott MG
Clin Chem 2011 Feb;57(2):344-6
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IFRD1 Is a Candidate Gene for SMNA on Chromosome 7q22-q23
Brkanac Z, Spencer D, Shendure J, Robertson PD, Matsushita M, Vu T, Bird TD, Olson MV, Raskind WH
Am J Hum Genet 2009 May;84(5):692-7
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Growth Phenotypes of Pseudomonas Aeruginosa LasR Mutants Adapted to the Airways of Cystic Fibrosis Patients
D'Argenio DA, Wu M, Hoffman LR, Kulasekara HD, Deziel E, Smith EE, Nguyen H, Ernst RK, Larson Freeman TJ, Spencer DH, Brittnacher M, Hayden HS, Selgrade S, Klausen M, Goodlett DR, Burns JL, Ramsey BW, Miller SI
Mol Microbiol 2007 Apr;64(2):512-33
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Detecting Disease-Causing Mutations in the Human Genome by Haplotype Matching
Spencer DH, Bubb KL, Olson MV
Am J Hum Genet 2006 Nov;79(5):958-64
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Evidence for Diversifying Selection at the Pyoverdine Locus of Pseudomonas Aeruginosa
Smith EE, Sims EH, Spencer DH, Kaul R, Olson MV
J Bacteriol 2005 Mar;187(6):2138-47
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Genome Mosaicism Is Conserved but Not Unique in Pseudomonas Aeruginosa Isolates From the Airways of Young Children With Cystic Fibrosis
Ernst RK, D'Argenio DA, Ichikawa JK, Bangera MG, Selgrade S, Burns JL, Hiatt P, McCoy K, Brittnacher M, Kas A, Spencer DH, Olson MV, Ramsey BW, Lory S, Miller SI
Environ Microbiol 2003 Dec;5(12):1341-9
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Comprehensive Transposon Mutant Library of Pseudomonas Aeruginosa
Jacobs MA, Alwood A, Thaipisuttikul I, Spencer D, Haugen E, Ernst S, Will O, Kaul R, Raymond C, Levy R, Chun-Rong L, Guenthner D, Bovee D, Olson MV, Manoil C
Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14339-44
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Whole-Genome Sequence Variation Among Multiple Isolates of Pseudomonas Aeruginosa
Spencer DH, Kas A, Smith EE, Raymond CK, Sims EH, Hastings M, Burns JL, Kaul R, Olson MV
J Bacteriol 2003 Feb;185(4):1316-25
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Genetic Variation at the O-Antigen Biosynthetic Locus in Pseudomonas Aeruginosa
Raymond CK, Sims EH, Kas A, Spencer DH, Kutyavin TV, Ivey RG, Zhou Y, Kaul R, Clendenning JB, Olson MV
J Bacteriol 2002 Jul;184(13):3614-22
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Complete Genome Sequence of Pseudomonas Aeruginosa PAO1, an Opportunistic Pathogen
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
Nature 2000 Aug 31;406(6799):959-64
Invited Publications