Brian A. Van Tine, MD, PhD

Professor

Phone: 314-747-3096
Fax: 314-362-7086
Email: bvantine@nospam.wustl.edu

Address:
Division of Oncology
Mail Stop 8076-0041-03
Washington University
660 South Euclid Avenue
St. Louis, MO 63110

Room 3302, Couch Biomedical Research Building (office)

Admin:
Terrie Stald
tstald@wustl.edu

Clinical Interests

Research Interests

Research

Sarcomas are a rare group of over 100 types of tumors of mesenchymal origin that can be divided into 2 categories: soft tissue sarcomas and bone sarcomas. Our main objective is to delineate the molecular and genetic events underlying sarcoma pathogenesis. We work to identify metabolic deficiencies in sarcoma that can be used as therapeutic opportunities. We also generate new models that reflect the disease in patients by establishing pedigreed xenografts in immuno-deficient mice and their corresponding cell lines. Additionally, we study argininosuccinate synthase 1 (ASS1), a biomarker that is lost and is a sign of poor prognosis for sarcoma. When ASS1 is not expressed, arginine becomes an essential amino acid that must be delivered by the diet. We are testing whether the ASS1-deficiency of sarcomas may be exploited using the arginine-lowering agent, PEGylated arginine deiminase (ADI-PEG20). We have shown that we can use arginine starvation to change the metabolic transporter profile on the surface of cells, thus allowing chemotherapy to work. We are presently working to better delineate the in vivo adaptation that occurs in tumors.

Van Tine Lab

Profiles (publications)

WU Physician Bio

Biosketch

Education

2005: MD, University of Alabama, Birmingham, AL
2003: PhD, University of Alabama, Birmingham, AL
1995: BS in Chemistry and BS in Biochemistry, University of Arizona, Tucson, AZ

Post-Graduate Training

2011-2007: Oncology Fellowship, Barnes-Jewish Hospital, Washington University, St. Louis, MO
2010-2009: Chief Fellow, Hematology and Oncology, Washington University, St. Louis, MO
2007-2006: Internal Medicine Residency, Barnes-Jewish Hospital, Washington University, St. Louis, MO
2006-2005: Internal Medicine Internship, Barnes-Jewish Hospital, Washington University, St. Louis, MO

Academic Positions

present-2021: Professor of Medicine, Division of Medical Oncology, Washington University, St. Louis, MO
present-2021: Professor of Pediatrics, Clinician, Washington University, St. Louis, MO
present-2011: Sarcoma Program Director, Division of Medical Oncology, Washington University, St. Louis, MO
2021-2020: Associate Professor of Pediatrics, Clinician, Washington University, St. Louis, MO
2021-2016: Associate Professor of Medicine, Division of Medical Oncology, Washington University, St. Louis, MO
2016-2011: Assistant Professor of Medicine, Division of Medical Oncology, Washington University, St. Louis, MO

Appointments & Committees

present-2022: Permanent Member, NIH Mechanisms of Cancer Therapeutics-1 [MCT1] Study Section
present-2021: Ovarian Cancer Research Working Group, Washington University
present-2021: Co-Director, Center for Early Phase Therapeutics, Washington University
present-2021: Ad Hoc NIH Mechanisms of Cancer Therapeutics-1 [MCT1] Study Section
present-2021: Sarcoma Foundation of America Medical Advisory Board
present-2021: National Cancer Institute’s NCTN Core Correlative Sciences Committees (NCTN-CCSC)
present-2020: AACR Pediatric Cancer Research Grants Scientific Review Committee
present-2020: Pediatric Focus Group-Steering Committee, Siteman Cancer Center
present-2020: Co-Director, Adolescent and Young Adult Program, Washington University
present-2019: AACR Annual Meeting Clinical Trials Committee
present-2018: Co-Chair, Alliance Sarcoma Working Group
present-2018: Siteman Cancer Center Protocol Review and Monitoring Committee
present-2016: National Leiomyosarcoma Foundation Executive Committee
present-2015: SARC Developmental Therapeutics Committee
present-2015: Siteman Steering Committee for Solid Tumors
present-2014: Correlative Vice Chair, Alliance Developmental Therapeutics Committee
present-2014: NRG Sarcoma Committee
present-2010: Organizer and Moderator, Multidisciplinary Sarcoma Tumor Board, Washington University
2021-2020: Chair, Midwest Sarcoma Trials Partnership
2016: Siteman Cancer Center Genetics Program Committee
2015: Co-Chair, AACR Basic Science of Sarcoma Meeting
2013-2011: NCCN Panel of Soft Tissue Sarcoma

Board Certification

2024-2014: Medical Oncology
2019-2009: Internal Medicine

Honors & Awards

2014: Presented the 2014 Rosenfeld Lecture for the Sarcoma Alliance for Research and Collaboration
2011: 1st Place Poster “Loss of Taspase1 Abrogates HER2/neu Induced Breast Cancer”, Washington University in St. Louis Breast Cancer Symposium
2011-2005: Physician Scientist Training Program, Washington University in St. Louis
2003: Edward S. Reynolds Award for Investigative Pathology – National Research Day Forum, Galveston, TX
2001: Student Award for excellent presentation at the 19th International Papillomavirus Conference, Florianopolis, Brazil
2001: UAB Comprehensive Cancer Center Poster Competition – Second Place
2001: UAB Medical Student Research Day – First Place
2001: Dean’s Award for the Joint Health Sciences
1998: Participant in the Cold Spring Harbor Laboratory Summer Course: Advanced In Situ and Immunohistochemistry
1997: Howard Hughes Medical Institute Summer Student Program

Editorial Boards

present-2015: Journal of Orthopaedic Research
2023-2021: Rare Tumors
2023-2018: Journal of Clinical Oncology
2022-2021: Clinical Cancer Research
2019-2014: Annals of Oncology

Professional Societies

present-2018: European Society for Medical Oncology
present-2011: Connective Tissue Oncology Society
present-2011: American Academy of Cancer Research
present-2007: American Society for Clinical Oncology